Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 121 to 180 of 15,838 scaffolds
2-Phenylthiophene174 chemicals, 2 rings![Scaffold c1cnc2[nH]ncc2c1](/scaffold/GVLRTOYGRNLSDW-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo(3,4-b)pyridine173 chemicals, 2 rings
1-(Phenylmethyl)pyrrolidine172 chemicals, 2 rings
Isatin171 chemicals, 2 rings
1-Benzyl-1H-benzimidazole168 chemicals, 3 rings
5-[(1,3-Diphenylpyrazol-4-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one168 chemicals, 4 rings
2-Phenylpyrrolidine167 chemicals, 2 rings
Chromone167 chemicals, 2 rings![Scaffold O=c1[nH]c(=O)c2c(ncn2Cc2ccccc2)[nH]1](/scaffold/XDUTVTQACWYOMX-UHFFFAOYSA-N/structure.svg)
7-Benzyl-1H-purine-2,6(3H,7H)-dione167 chemicals, 3 rings
Phenothiazine166 chemicals, 3 rings
Isoxazole, 5-phenyl-165 chemicals, 2 rings
Benzenesulfonamide, N-benzyl-164 chemicals, 2 rings
2H-Pyran, tetrahydro-2-phenoxy-164 chemicals, 2 rings
Benzoylpiperidine164 chemicals, 2 rings
O=C(NN=Cc1ccc(OC(=O)c2ccccc2)cc1)c1ccccc1162 chemicals, 3 rings
2H-1,4-Benzoxazin-3(4H)-one160 chemicals, 2 rings![Scaffold O=c1[nH]c2ccccc2[nH]1](/scaffold/SILNNFMWIMZVEQ-UHFFFAOYSA-N/structure.svg)
2-Hydroxy benzimidazole159 chemicals, 2 rings
C1=CC(c2ccccc2)C=CN1155 chemicals, 2 rings
Diazene, naphthalenylphenyl-153 chemicals, 3 rings
N,3-Diphenylpropanamide153 chemicals, 2 rings![Scaffold c1ccc(-c2nn[nH]n2)cc1](/scaffold/MARUHZGHZWCEQU-UHFFFAOYSA-N/structure.svg)
5-Phenyl-1H-tetrazole152 chemicals, 2 rings
Anthracene150 chemicals, 3 rings
N-Phenylthiophene-2-carboxamide150 chemicals, 2 rings
Pyrazolo(1,5-a)pyridine149 chemicals, 2 rings
Fac43QQ4A2149 chemicals, 4 rings
4-(Phenylsulfonyl)morpholine148 chemicals, 2 rings
N-Phenethylbenzamide147 chemicals, 2 rings
1-(Phenylsulfonyl)pyrrolidine146 chemicals, 2 rings
O=C(COc1ccccc1)NN=Cc1ccc(OC(=O)c2ccccc2)cc1146 chemicals, 3 rings
Triphenylmethane145 chemicals, 3 rings
2-Phenyl-1,3-oxazole145 chemicals, 2 rings![Scaffold O=c1[nH]c2ccccc2o1](/scaffold/ASSKVPFEZFQQNQ-UHFFFAOYSA-N/structure.svg)
2(3H)-Benzoxazolone143 chemicals, 2 rings
c1ccc2c(c1)CCC1C2CCC2CCCC21143 chemicals, 4 rings
Spiro[3.3]heptane143 chemicals, 2 rings
Dibenzylamine142 chemicals, 2 rings
1,4-Naphthoquinone141 chemicals, 2 rings![Scaffold O=c1[nH]cnc2c1ncn2C1CCCO1](/scaffold/JBXHFRZBULGPSC-UHFFFAOYSA-N/structure.svg)
9-(Oxolan-2-yl)-3H-purin-6-one141 chemicals, 3 rings
Nicotinanilide140 chemicals, 2 rings
4-Benzylmorpholine139 chemicals, 2 rings
C1OC2CC1C2138 chemicals, 3 rings
Isoindoline137 chemicals, 2 rings
1-Phenyl-1H-tetrazole137 chemicals, 2 rings
2-Phenylimidazo(1,2-a)pyridine137 chemicals, 3 rings
2-Phenylacetophenone137 chemicals, 2 rings
3,4-Dihydro-2H-1,4-benzoxazine137 chemicals, 2 rings
O=C(CN1C(=O)C(=C2SC(=S)NC2=O)c2ccccc21)Nc1ccccc1135 chemicals, 4 rings
Acridine135 chemicals, 3 rings
O=C1CCCC2=C1C(c1ccccc1)C=CN2c1ccccc1135 chemicals, 4 rings
Quinone134 chemicals, 1 ring
Diphenyl sulfone134 chemicals, 2 rings
3-Phenylthiophene133 chemicals, 2 rings
Benzothiophene, 4,5,6,7-tetrahydro-132 chemicals, 2 rings
1-Tetralone131 chemicals, 2 rings
O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)Nc1ccccc1131 chemicals, 4 rings
1-Phenyl-4-(phenylsulfonyl)piperazine130 chemicals, 3 rings
Benzylcyclopropane130 chemicals, 2 rings
1-Phenyl-1H-1,2,4-triazole128 chemicals, 2 rings
Phthalimidine128 chemicals, 2 rings
1-Benzyl-3-phenyl-2-thiourea127 chemicals, 2 rings
O=C1C(=O)N(c2nccs2)C(c2ccccc2)C1=Cc1ccccc1127 chemicals, 4 rings