Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 61 to 120 of 15,838 scaffolds
1,4-Benzodioxan299 chemicals, 2 rings
Benzene, cyclobutyl-298 chemicals, 2 rings![Scaffold c1ncc2[nH]cnc2n1](/scaffold/KDCGOANMDULRCW-UHFFFAOYSA-N/structure.svg)
Purine295 chemicals, 2 rings
Benzoxazole292 chemicals, 2 rings
1-Benzylpiperidine283 chemicals, 2 rings
Stilbene279 chemicals, 2 rings
4-Phenylpiperidine277 chemicals, 2 rings
Cyclohexylbenzene274 chemicals, 2 rings
1-Benzyl-1H-pyrazole271 chemicals, 2 rings![Scaffold c1cnc2[nH]ccc2c1](/scaffold/MVXVYAKCVDQRLW-UHFFFAOYSA-N/structure.svg)
1H-Pyrrolo(2,3-b)pyridine270 chemicals, 2 rings![Scaffold c1ccc2c(c1)[nH]c1ccccc12](/scaffold/UJOBWOGCFQCDNV-UHFFFAOYSA-N/structure.svg)
Carbazole269 chemicals, 3 rings
1-Benzylpiperazine267 chemicals, 2 rings
1-(Phenylsulfonyl)piperidine266 chemicals, 2 rings
N-(Benzylideneamino)benzamide265 chemicals, 2 rings![Scaffold O=c1[nH]cnc2ccccc12](/scaffold/QMNUDYFKZYBWQX-UHFFFAOYSA-N/structure.svg)
4(1H)-Quinazolinone264 chemicals, 2 rings
Dibenzyl264 chemicals, 2 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1ccccc1264 chemicals, 2 rings
N-Benzoylbenzylamine260 chemicals, 2 rings
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals, 2 rings
Triphenylphosphine252 chemicals, 3 rings
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1251 chemicals, 2 rings
Oxindole247 chemicals, 2 rings
Pyrazolo(1,5-a)pyrimidine244 chemicals, 2 rings
Flavanone239 chemicals, 3 rings
2-Phenoxypyridine238 chemicals, 2 rings![Scaffold c1ccc(-c2nc[nH]n2)cc1](/scaffold/NYMLZIFRPNYAHS-UHFFFAOYSA-N/structure.svg)
1H-1,2,4-Triazole, 5-phenyl-238 chemicals, 2 rings
Isoflavone235 chemicals, 3 rings
1-Phenylpiperidine235 chemicals, 2 rings
1-Phenylpyrrolidin-2-one234 chemicals, 2 rings
2-Phenylquinoline221 chemicals, 3 rings
N,2-Diphenylacetamide219 chemicals, 2 rings
2-Phenylpyridine219 chemicals, 2 rings
Quinoxaline214 chemicals, 2 rings
3-Phenylisoxazole211 chemicals, 2 rings
Bicyclo(1.1.1)pentane209 chemicals, 3 rings
N-Phenyl-2-furancarboxamide208 chemicals, 2 rings
4-Phenylmorpholine202 chemicals, 2 rings
2-Oxo-2-phenylethyl 2-phenyl-4-quinolinecarboxylate202 chemicals, 4 rings
1-Indanone202 chemicals, 2 rings
1,3,4-Oxadiazole, 2-phenyl-200 chemicals, 2 rings
1-Phenylpyrrolidine199 chemicals, 2 rings
1-Phenyl-1H-1,2,3-triazole197 chemicals, 2 rings
3-Phenylpyrrolidine197 chemicals, 2 rings
Diphenyl sulfide195 chemicals, 2 rings
1-(Benzenesulfonyl)piperazine195 chemicals, 2 rings
C1=C2CCCCC2C2CCC3CCCC3C2C1193 chemicals, 4 rings![Scaffold c1ccc(-c2nc3ccccc3[nH]2)cc1](/scaffold/DWYHDSLIWMUSOO-UHFFFAOYSA-N/structure.svg)
2-Phenylbenzimidazole191 chemicals, 3 rings
3-(1,3,2-Dioxaborolan-2-yl)pyridine191 chemicals, 2 rings
3-Phenyl-1,2,4-oxadiazole187 chemicals, 2 rings
O=C(NN=Cc1ccc(OC(=O)c2ccccc2)cc1)C(=O)Nc1ccccc1187 chemicals, 3 rings
O=c1ncccn1C1CCCO1183 chemicals, 2 rings
O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21183 chemicals, 4 rings
O=C1NC(c2ccccc2)C(=Cc2ccccc2)C1=O183 chemicals, 3 rings![Scaffold c1ccc2[nH]nnc2c1](/scaffold/QRUDEWIWKLJBPS-UHFFFAOYSA-N/structure.svg)
1H-Benzotriazole183 chemicals, 2 rings
1-Phenylimidazole182 chemicals, 2 rings
Cyclopentylbenzene181 chemicals, 2 rings
Xanthone178 chemicals, 3 rings
1-Benzoyl-4-phenylpiperazine177 chemicals, 3 rings
Benzoxazole, 2-phenyl-175 chemicals, 3 rings
O=C(C=Cc1ccccc1)Nc1ccccc1175 chemicals, 2 rings