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Murcko scaffold

Ring system with 3 rings and 19 atoms

166 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 166
With full pages: 15

Scaffold SMILES

O=C1C(=Cc2ccccc2)C=NN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2ccccc2)C=NN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 166 chemicals

Methyl {2-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]phenoxy}acetate chemical structure, C20H18N2O4, CAS 432021-13-1

Methyl {2-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]phenoxy}acetate

CAS 432021-13-1C₂₀H₁₈N₂O₄

4-[(4Z)-4-[(4-Chlorophenyl)methylidene]-3-methyl-5-oxopyrazol-1-yl]benzenesulfonamide chemical structure, C17H14ClN3O3S, CAS 431907-05-0

4-[(4Z)-4-[(4-Chlorophenyl)methylidene]-3-methyl-5-oxopyrazol-1-yl]benzenesulfonamide

CAS 431907-05-0C₁₇H₁₄ClN₃O₃S

(4E)-4-[(4-Bromo-3-nitrophenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C17H12BrN3O3, CAS 311800-02-9

(4E)-4-[(4-Bromo-3-nitrophenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one

CAS 311800-02-9C₁₇H₁₂BrN₃O₃

(4E)-5-Methyl-2-phenyl-4-[(2-prop-2-enoxyphenyl)methylidene]pyrazol-3-one chemical structure, C20H18N2O2, CAS 112297-20-8

(4E)-5-Methyl-2-phenyl-4-[(2-prop-2-enoxyphenyl)methylidene]pyrazol-3-one

CAS 112297-20-8C₂₀H₁₈N₂O₂

(4E)-2-(3-Chloro-2-methylphenyl)-5-methyl-4-[(3,4,5-trimethoxyphenyl)methylidene]pyrazol-3-one chemical structure, C21H21ClN2O4, CAS 429636-72-6

(4E)-2-(3-Chloro-2-methylphenyl)-5-methyl-4-[(3,4,5-trimethoxyphenyl)methylidene]pyrazol-3-one

CAS 429636-72-6C₂₁H₂₁ClN₂O₄

(4Z)-4-[(3-Methoxy-4-prop-2-ynoxyphenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C21H18N2O3, CAS 345986-57-4

(4Z)-4-[(3-Methoxy-4-prop-2-ynoxyphenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one

CAS 345986-57-4C₂₁H₁₈N₂O₃

2-(3,4-Dichlorophenyl)-4-(3-methoxy-4-propoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H20Cl2N2O3, CAS 354541-73-4

2-(3,4-Dichlorophenyl)-4-(3-methoxy-4-propoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

CAS 354541-73-4C₂₁H₂₀Cl₂N₂O₃

2-[4-Chloro-2-[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy]acetic acid chemical structure, C19H15ClN2O4, CAS 540761-18-0

2-[4-Chloro-2-[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy]acetic acid

CAS 540761-18-0C₁₉H₁₅ClN₂O₄

(4Z)-5-tert-Butyl-4-[(3,4-dimethoxyphenyl)methylidene]-2-phenylpyrazol-3-one chemical structure, C22H24N2O3, CAS 1024742-86-6

(4Z)-5-tert-Butyl-4-[(3,4-dimethoxyphenyl)methylidene]-2-phenylpyrazol-3-one

CAS 1024742-86-6C₂₂H₂₄N₂O₃

Methyl 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-{[2,6-dichloro-4-(trifluoromethyl)phenyl]methylene}-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylate chemical structure, C20H8Cl4F6N2O3, CAS 259175-30-9

Methyl 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-{[2,6-dichloro-4-(trifluoromethyl)phenyl]methylene}-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylate

CAS 259175-30-9C₂₀H₈Cl₄F₆N₂O₃

4-(2,3-Dibromo-5-ethoxy-4-methoxybenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C20H18Br2N2O3, CAS 353476-31-0

4-(2,3-Dibromo-5-ethoxy-4-methoxybenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

CAS 353476-31-0C₂₀H₁₈Br₂N₂O₃

4-{4-[Bis(2-chloroethyl)amino]benzylidene}-2-(4-ethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C23H25Cl2N3O, CAS 353488-61-6

4-{4-[Bis(2-chloroethyl)amino]benzylidene}-2-(4-ethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

CAS 353488-61-6C₂₃H₂₅Cl₂N₃O

4-((4-(Dimethylamino)phenyl)methylene)-3-(tert-butyl)-1-phenyl-2-pyrazolin-5-one chemical structure, C22H25N3O, CAS 1025259-84-0

4-((4-(Dimethylamino)phenyl)methylene)-3-(tert-butyl)-1-phenyl-2-pyrazolin-5-one

CAS 1025259-84-0C₂₂H₂₅N₃O

2-(3,4-Dichlorophenyl)-4-(2-ethoxy-3,5-diiodobenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H14Cl2I2N2O2, CAS 354541-37-0

2-(3,4-Dichlorophenyl)-4-(2-ethoxy-3,5-diiodobenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

CAS 354541-37-0C₁₉H₁₄Cl₂I₂N₂O₂

4-(2,3-Dibromo-4,5-diethoxybenzylidene)-2-(3,4-dichlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H18Br2Cl2N2O3, CAS 353478-28-1

4-(2,3-Dibromo-4,5-diethoxybenzylidene)-2-(3,4-dichlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

CAS 353478-28-1C₂₁H₁₈Br₂Cl₂N₂O₃

N-(4-((3-(tert-Butyl)-5-oxo-1-phenyl-2-pyrazolin-4-ylidene)methyl)phenyl)ethanamide chemical structure, C22H23N3O2, CAS 1025561-80-1

N-(4-((3-(tert-Butyl)-5-oxo-1-phenyl-2-pyrazolin-4-ylidene)methyl)phenyl)ethanamide

CAS 1025561-80-1C₂₂H₂₃N₃O₂

5-Methyl-4-(1-(4-methylphenyl)ethylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H18N2O, CAS 308101-33-9

5-Methyl-4-(1-(4-methylphenyl)ethylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

CAS 308101-33-9C₁₉H₁₈N₂O

4-(3-Methoxy-4-propoxybenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H22N2O3, CAS 353780-54-8

4-(3-Methoxy-4-propoxybenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

CAS 353780-54-8C₂₁H₂₂N₂O₃

3-(tert-Butyl)-1-(4-nitrophenyl)-4-((3,4,5-trimethoxyphenyl)methylene)-2-pyrazolin-5-one chemical structure, C23H25N3O6, CAS 1025878-53-8

3-(tert-Butyl)-1-(4-nitrophenyl)-4-((3,4,5-trimethoxyphenyl)methylene)-2-pyrazolin-5-one

CAS 1025878-53-8C₂₃H₂₅N₃O₆

3-(tert-Butyl)-4-((5-bromo-2-methoxyphenyl)methylene)-1-phenyl-2-pyrazolin-5-one chemical structure, C21H21BrN2O2, CAS 1025240-27-0

3-(tert-Butyl)-4-((5-bromo-2-methoxyphenyl)methylene)-1-phenyl-2-pyrazolin-5-one

CAS 1025240-27-0C₂₁H₂₁BrN₂O₂

(4Z)-5-tert-Butyl-4-[(2,4-dichlorophenyl)methylidene]-2-(4-nitrophenyl)pyrazol-3-one chemical structure, C20H17Cl2N3O3, CAS 1025673-99-7

(4Z)-5-tert-Butyl-4-[(2,4-dichlorophenyl)methylidene]-2-(4-nitrophenyl)pyrazol-3-one

CAS 1025673-99-7C₂₀H₁₇Cl₂N₃O₃

(4E)-4-[(4-Ethoxyphenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C19H18N2O2, CAS 345986-59-6

(4E)-4-[(4-Ethoxyphenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one

CAS 345986-59-6C₁₉H₁₈N₂O₂

Benzenesulfonic acid, 4-(4-((4-(bis(2-cyanoethyl)amino)phenyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)- chemical structure, C23H21N5O4S, CAS 68541-05-9

Benzenesulfonic acid, 4-(4-((4-(bis(2-cyanoethyl)amino)phenyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-

CAS 68541-05-9C₂₃H₂₁N₅O₄S

4-(2-Chloro-4-dimethylaminobenzylidene)-1-(4'-carboxyphenyl)-3-methylpyrazol-5-one chemical structure, C20H18ClN3O3, CAS 68892-09-1

4-(2-Chloro-4-dimethylaminobenzylidene)-1-(4'-carboxyphenyl)-3-methylpyrazol-5-one

CAS 68892-09-1C₂₀H₁₈ClN₃O₃