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Murcko scaffold

(4-Phenylpiperazin-1-yl)(piperidin-4-yl)methanone scaffold

40 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
40
With full pages
3
Scaffold SMILES

O=C(C1CCNCC1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Phenylpiperazin-1-yl)(piperidin-4-yl)methanone page
Murcko scaffold O=C(C1CCNCC1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

[4-(2-Fluorophenyl)piperazin-1-yl][1-(2-methylpropyl)piperidin-4-yl]methanone chemical structure, C20H30FN3O, CAS 429637-26-3
[4-(2-Fluorophenyl)piperazin-1-yl][1-(2-methylpropyl)piperidin-4-yl]methanone
CAS 429637-26-3C20H30FN3O
(4-Phenylpiperazin-1-yl)(piperidin-4-yl)methanone chemical structure, C16H23N3O, CAS 731832-24-9
(4-Phenylpiperazin-1-yl)(piperidin-4-yl)methanone
CAS 731832-24-9C16H23N3O
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone chemical structure, C18H26ClN3O3S, CAS 593263-77-5
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone
CAS 593263-77-5C18H26ClN3O3S
[4-(2-Methoxyphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone chemical structure, C18H27N3O4S, CAS 693823-00-6
[4-(2-Methoxyphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone
CAS 693823-00-6C18H27N3O4S
[4-(3-Chlorophenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone chemical structure, C17H24ClN3O3S, CAS 693805-68-4
[4-(3-Chlorophenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone
CAS 693805-68-4C17H24ClN3O3S
(1-(Methylsulfonyl)piperidin-4-yl)(4-phenylpiperazin-1-yl)methanone chemical structure, C17H25N3O3S, CAS 693815-16-6
(1-(Methylsulfonyl)piperidin-4-yl)(4-phenylpiperazin-1-yl)methanone
CAS 693815-16-6C17H25N3O3S
[4-(2,3-Dimethylphenyl)piperazin-1-yl][1-(2-methylpropyl)piperidin-4-yl]methanone chemical structure, C22H35N3O, CAS 429639-98-5
[4-(2,3-Dimethylphenyl)piperazin-1-yl][1-(2-methylpropyl)piperidin-4-yl]methanone
CAS 429639-98-5C22H35N3O
[4-(4-Methoxyphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone chemical structure, C18H27N3O4S, CAS 693796-83-7
[4-(4-Methoxyphenyl)piperazin-1-yl]-(1-methylsulfonylpiperidin-4-yl)methanone
CAS 693796-83-7C18H27N3O4S
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1-ethylsulfonylpiperidin-4-yl)methanone chemical structure, C19H28ClN3O3S, CAS 898215-69-5
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1-ethylsulfonylpiperidin-4-yl)methanone
CAS 898215-69-5C19H28ClN3O3S
(1-Ethylsulfonylpiperidin-4-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H29N3O4S, CAS 879048-34-7
(1-Ethylsulfonylpiperidin-4-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 879048-34-7C19H29N3O4S
(1-Ethylsulfonylpiperidin-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C18H26FN3O3S, CAS 879048-22-3
(1-Ethylsulfonylpiperidin-4-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 879048-22-3C18H26FN3O3S
[4-(3-Chlorophenyl)piperazin-1-yl]-(1-ethylsulfonylpiperidin-4-yl)methanone chemical structure, C18H26ClN3O3S, CAS 879048-28-9
[4-(3-Chlorophenyl)piperazin-1-yl]-(1-ethylsulfonylpiperidin-4-yl)methanone
CAS 879048-28-9C18H26ClN3O3S
1-[4-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C22H33N3O3, CAS 945360-06-5
1-[4-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one
CAS 945360-06-5C22H33N3O3
1-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C21H30ClN3O2, CAS 945331-90-8
1-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one
CAS 945331-90-8C21H30ClN3O2
2,2-Dimethyl-1-[4-[4-[3-(trifluoromethyl)phenyl]piperazine-1-carbonyl]piperidin-1-yl]propan-1-one chemical structure, C22H30F3N3O2, CAS 945344-12-7
2,2-Dimethyl-1-[4-[4-[3-(trifluoromethyl)phenyl]piperazine-1-carbonyl]piperidin-1-yl]propan-1-one
CAS 945344-12-7C22H30F3N3O2
1-[4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C23H35N3O2, CAS 945343-95-3
1-[4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]piperidin-1-yl]-2,2-dimethylpropan-1-one
CAS 945343-95-3C23H35N3O2
1-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]piperidin-1-yl]ethanone chemical structure, C18H24ClN3O2, CAS 915886-44-1
1-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]piperidin-1-yl]ethanone
CAS 915886-44-1C18H24ClN3O2
1-[4-[4-(2-Methylphenyl)piperazine-1-carbonyl]piperidin-1-yl]ethanone chemical structure, C19H27N3O2, CAS 915919-25-4
1-[4-[4-(2-Methylphenyl)piperazine-1-carbonyl]piperidin-1-yl]ethanone
CAS 915919-25-4C19H27N3O2
1-Acetyl-4-{[4-(5-chloro-2-methylphenyl)piperazinyl]carbonyl}piperidine chemical structure, C19H26ClN3O2, CAS 915903-34-3
1-Acetyl-4-{[4-(5-chloro-2-methylphenyl)piperazinyl]carbonyl}piperidine
CAS 915903-34-3C19H26ClN3O2
1-(4-{[4-(4-Fluorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)-2,2-dimethylpropan-1-one chemical structure, C21H30FN3O2, CAS 945311-51-3
1-(4-{[4-(4-Fluorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)-2,2-dimethylpropan-1-one
CAS 945311-51-3C21H30FN3O2
1-(4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)-2,2-dimethylpropan-1-one chemical structure, C21H30FN3O2, CAS 945344-20-7
1-(4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)-2,2-dimethylpropan-1-one
CAS 945344-20-7C21H30FN3O2
4-{[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]carbonyl}-N,N-dimethylpiperidine-1-sulfonamide chemical structure, C19H29ClN4O3S, CAS 931299-41-1
4-{[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]carbonyl}-N,N-dimethylpiperidine-1-sulfonamide
CAS 931299-41-1C19H29ClN4O3S
4-(4-Fluorophenyl)piperazinyl 4-piperidyl ketone chemical structure, C16H22FN3O, CAS 1579893-76-7
4-(4-Fluorophenyl)piperazinyl 4-piperidyl ketone
CAS 1579893-76-7C16H22FN3O
1-(4-{[4-(3-Chlorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)butan-1-one chemical structure, C20H28ClN3O2, CAS 1158739-63-9
1-(4-{[4-(3-Chlorophenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)butan-1-one
CAS 1158739-63-9C20H28ClN3O2