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Murcko scaffold

2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrimidine scaffold

64 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
64
With full pages
15
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(c2ncccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrimidine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(c2ncccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 64 chemicals

2-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]pyrimidine chemical structure, C14H15ClN4O2S, CAS 334973-48-7
2-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]pyrimidine
CAS 334973-48-7C14H15ClN4O2S
2-(4-Tosylpiperazin-1-yl)pyrimidine chemical structure, C15H18N4O2S, CAS 380466-33-1
2-(4-Tosylpiperazin-1-yl)pyrimidine
CAS 380466-33-1C15H18N4O2S
2-(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)pyrimidine chemical structure, C14H15FN4O2S, CAS 353771-38-7
2-(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)pyrimidine
CAS 353771-38-7C14H15FN4O2S
N-(4-{[4-(Pyrimidin-2-yl)piperazin-1-yl]sulfonyl}phenyl)acetamide chemical structure, C16H19N5O3S, CAS 545383-46-8
N-(4-{[4-(Pyrimidin-2-yl)piperazin-1-yl]sulfonyl}phenyl)acetamide
CAS 545383-46-8C16H19N5O3S
2-{4-[(2-Nitrophenyl)sulfonyl]piperazino}pyrimidine chemical structure, C14H15N5O4S, CAS 545358-46-1
2-{4-[(2-Nitrophenyl)sulfonyl]piperazino}pyrimidine
CAS 545358-46-1C14H15N5O4S
2-[4-(2,5-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C16H20N4O2S, CAS 785812-73-9
2-[4-(2,5-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 785812-73-9C16H20N4O2S
4-Chloro-2,5-dimethyl-1-[(4-pyrimidin-2-ylpiperazinyl)sulfonyl]benzene chemical structure, C16H19ClN4O2S, CAS 256417-28-4
4-Chloro-2,5-dimethyl-1-[(4-pyrimidin-2-ylpiperazinyl)sulfonyl]benzene
CAS 256417-28-4C16H19ClN4O2S
4-(4-Pyrimidin-2-ylpiperazin-1-yl)sulfonylbenzonitrile chemical structure, C15H15N5O2S, CAS 256417-35-3
4-(4-Pyrimidin-2-ylpiperazin-1-yl)sulfonylbenzonitrile
CAS 256417-35-3C15H15N5O2S
2-(4-((4-Methoxy-3-nitrophenyl)sulfonyl)piperazin-1-yl)pyrimidine chemical structure, C15H17N5O5S, CAS 496777-52-7
2-(4-((4-Methoxy-3-nitrophenyl)sulfonyl)piperazin-1-yl)pyrimidine
CAS 496777-52-7C15H17N5O5S
2-(4-{[4-(tert-Butyl)phenyl]sulfonyl}piperazino)pyrimidine chemical structure, C18H24N4O2S, CAS 866153-26-6
2-(4-{[4-(tert-Butyl)phenyl]sulfonyl}piperazino)pyrimidine
CAS 866153-26-6C18H24N4O2S
2-{4-[(2,5-Dimethoxyphenyl)sulfonyl]piperazino}pyrimidine chemical structure, C16H20N4O4S, CAS 725215-07-6
2-{4-[(2,5-Dimethoxyphenyl)sulfonyl]piperazino}pyrimidine
CAS 725215-07-6C16H20N4O4S
2-{4-[(4-Chloro-2-nitrophenyl)sulfonyl]piperazino}pyrimidine chemical structure, C14H14ClN5O4S, CAS 866153-27-7
2-{4-[(4-Chloro-2-nitrophenyl)sulfonyl]piperazino}pyrimidine
CAS 866153-27-7C14H14ClN5O4S
2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrimidine chemical structure, C14H16N4O2S, CAS 354119-37-2
2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrimidine
CAS 354119-37-2C14H16N4O2S
2-[4-(2,4-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C16H20N4O2S, CAS 898059-81-9
2-[4-(2,4-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 898059-81-9C16H20N4O2S
2-[4-(3,4-Difluorophenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C14H14F2N4O2S, CAS 898059-75-1
2-[4-(3,4-Difluorophenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 898059-75-1C14H14F2N4O2S
2-[4-(4-Ethylphenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C16H20N4O2S, CAS 898059-44-4
2-[4-(4-Ethylphenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 898059-44-4C16H20N4O2S
2-[4-(3,4-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C16H20N4O2S, CAS 898059-47-7
2-[4-(3,4-Dimethylphenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 898059-47-7C16H20N4O2S
2-[4-(4-Butylphenyl)sulfonylpiperazin-1-yl]pyrimidine chemical structure, C18H24N4O2S, CAS 898059-39-7
2-[4-(4-Butylphenyl)sulfonylpiperazin-1-yl]pyrimidine
CAS 898059-39-7C18H24N4O2S
2-{4-[(2,5-Difluorophenyl)sulfonyl]piperazin-1-yl}pyrimidine chemical structure, C14H14F2N4O2S, CAS 725215-06-5
2-{4-[(2,5-Difluorophenyl)sulfonyl]piperazin-1-yl}pyrimidine
CAS 725215-06-5C14H14F2N4O2S
N-Ethyl-6-methyl-2-(4-tosylpiperazin-1-yl)pyrimidin-4-amine chemical structure, C18H25N5O2S, CAS 923222-40-6
N-Ethyl-6-methyl-2-(4-tosylpiperazin-1-yl)pyrimidin-4-amine
CAS 923222-40-6C18H25N5O2S
2-(4-((3,4-Dimethylphenyl)sulfonyl)piperazin-1-yl)-N-ethyl-6-methylpyrimidin-4-amine chemical structure, C19H27N5O2S, CAS 923682-41-1
2-(4-((3,4-Dimethylphenyl)sulfonyl)piperazin-1-yl)-N-ethyl-6-methylpyrimidin-4-amine
CAS 923682-41-1C19H27N5O2S
N-Ethyl-2-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)-6-methylpyrimidin-4-amine chemical structure, C18H25N5O3S, CAS 923150-52-1
N-Ethyl-2-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)-6-methylpyrimidin-4-amine
CAS 923150-52-1C18H25N5O3S
2-(4-((4-Ethoxyphenyl)sulfonyl)piperazin-1-yl)-N-ethyl-6-methylpyrimidin-4-amine chemical structure, C19H27N5O3S, CAS 923201-98-3
2-(4-((4-Ethoxyphenyl)sulfonyl)piperazin-1-yl)-N-ethyl-6-methylpyrimidin-4-amine
CAS 923201-98-3C19H27N5O3S
2-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]-N-ethyl-6-methylpyrimidin-4-amine chemical structure, C17H22ClN5O2S, CAS 923146-20-7
2-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]-N-ethyl-6-methylpyrimidin-4-amine
CAS 923146-20-7C17H22ClN5O2S