CompoundList
Sign in
Murcko scaffold

1-(Phenylsulfonyl)-4-(2-pyridinyl)piperazine scaffold

77 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
77
With full pages
24
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenylsulfonyl)-4-(2-pyridinyl)piperazine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

4-(2-Pyridyl)-1-((2,4,6-trimethylphenyl)sulfonyl)piperazine chemical structure, C18H23N3O2S, CAS 381675-86-1
4-(2-Pyridyl)-1-((2,4,6-trimethylphenyl)sulfonyl)piperazine
CAS 381675-86-1C18H23N3O2S
1-(2-Nitrophenyl)sulfonyl-4-pyridin-2-ylpiperazine chemical structure, C15H16N4O4S, CAS 6122-91-4
1-(2-Nitrophenyl)sulfonyl-4-pyridin-2-ylpiperazine
CAS 6122-91-4C15H16N4O4S
1-[(4-Methylphenyl)sulfonyl]-4-(2-pyridinyl)piperazine chemical structure, C16H19N3O2S, CAS 190064-68-7
1-[(4-Methylphenyl)sulfonyl]-4-(2-pyridinyl)piperazine
CAS 190064-68-7C16H19N3O2S
1-[(4-Fluorophenyl)sulfonyl]-4-(2-pyridinyl)piperazine chemical structure, C15H16FN3O2S, CAS 433245-48-8
1-[(4-Fluorophenyl)sulfonyl]-4-(2-pyridinyl)piperazine
CAS 433245-48-8C15H16FN3O2S
1-(4-Nitrobenzenesulfonyl)-4-(pyridin-2-yl)piperazine chemical structure, C15H16N4O4S, CAS 71422-42-9
1-(4-Nitrobenzenesulfonyl)-4-(pyridin-2-yl)piperazine
CAS 71422-42-9C15H16N4O4S
1-(Phenylsulfonyl)-4-(2-pyridinyl)piperazine chemical structure, C15H17N3O2S, CAS 5879-57-2
1-(Phenylsulfonyl)-4-(2-pyridinyl)piperazine
CAS 5879-57-2C15H17N3O2S
4-Chloro-1-((4-(2-pyridyl)piperazinyl)sulfonyl)benzene chemical structure, C15H16ClN3O2S, CAS 6098-02-8
4-Chloro-1-((4-(2-pyridyl)piperazinyl)sulfonyl)benzene
CAS 6098-02-8C15H16ClN3O2S
2-[4-Chloro-2-methyl-5-(4-pyridin-2-ylpiperazin-1-yl)sulfonylphenoxy]acetamide chemical structure, C18H21ClN4O4S, CAS 700857-11-0
2-[4-Chloro-2-methyl-5-(4-pyridin-2-ylpiperazin-1-yl)sulfonylphenoxy]acetamide
CAS 700857-11-0C18H21ClN4O4S
N-(4-((4-(2-Pyridyl)piperazinyl)sulfonyl)phenyl)ethanamide chemical structure, C17H20N4O3S, CAS 296882-82-1
N-(4-((4-(2-Pyridyl)piperazinyl)sulfonyl)phenyl)ethanamide
CAS 296882-82-1C17H20N4O3S
1-((2,5-Dimethoxyphenyl)sulfonyl)-4-(2-pyridyl)piperazine chemical structure, C17H21N3O4S, CAS 497060-94-3
1-((2,5-Dimethoxyphenyl)sulfonyl)-4-(2-pyridyl)piperazine
CAS 497060-94-3C17H21N3O4S
N-(4-((4-(3-Chloro-5-(trifluoromethyl)-2-pyridyl)piperazinyl)sulfonyl)phenyl)ethanamide chemical structure, C18H18ClF3N4O3S, CAS 260368-20-5
N-(4-((4-(3-Chloro-5-(trifluoromethyl)-2-pyridyl)piperazinyl)sulfonyl)phenyl)ethanamide
CAS 260368-20-5C18H18ClF3N4O3S
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(4-methylphenyl)sulfonylpiperazine chemical structure, C17H17ClF3N3O2S, CAS 260442-08-8
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(4-methylphenyl)sulfonylpiperazine
CAS 260442-08-8C17H17ClF3N3O2S
1-(4-tert-Butylbenzenesulfonyl)-4-(pyridin-2-yl)piperazine chemical structure, C19H25N3O2S, CAS 690642-28-5
1-(4-tert-Butylbenzenesulfonyl)-4-(pyridin-2-yl)piperazine
CAS 690642-28-5C19H25N3O2S
1-(Pyridin-2-yl)-4-((2,3,5,6-tetramethylphenyl)sulfonyl)piperazine chemical structure, C19H25N3O2S, CAS 670270-54-9
1-(Pyridin-2-yl)-4-((2,3,5,6-tetramethylphenyl)sulfonyl)piperazine
CAS 670270-54-9C19H25N3O2S
1-(4-Methylbenzenesulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C17H18F3N3O2S, CAS 478077-40-6
1-(4-Methylbenzenesulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 478077-40-6C17H18F3N3O2S
1-(4-Methoxyphenyl)sulfonyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C17H18F3N3O3S, CAS 478077-41-7
1-(4-Methoxyphenyl)sulfonyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 478077-41-7C17H18F3N3O3S
1-[(4-Chlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)-2-pyridinyl]piperazine chemical structure, C16H15ClF3N3O2S, CAS 478077-42-8
1-[(4-Chlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)-2-pyridinyl]piperazine
CAS 478077-42-8C16H15ClF3N3O2S
1-(4-Methoxyphenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C17H18F3N3O3S, CAS 478077-45-1
1-(4-Methoxyphenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 478077-45-1C17H18F3N3O3S
1-(4-Bromophenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C16H15BrF3N3O2S, CAS 478077-46-2
1-(4-Bromophenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 478077-46-2C16H15BrF3N3O2S
1-(3,5-Dichlorophenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C16H14Cl2F3N3O2S, CAS 478077-47-3
1-(3,5-Dichlorophenyl)sulfonyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 478077-47-3C16H14Cl2F3N3O2S
N-[4-({4-[5-(Trifluoromethyl)-2-pyridinyl]piperazino}sulfonyl)phenyl]acetamide chemical structure, C18H19F3N4O3S, CAS 866131-24-0
N-[4-({4-[5-(Trifluoromethyl)-2-pyridinyl]piperazino}sulfonyl)phenyl]acetamide
CAS 866131-24-0C18H19F3N4O3S
2-{4-[(4-Fluorophenyl)sulfonyl]piperazino}-4,6-dimethylnicotinonitrile chemical structure, C18H19FN4O2S, CAS 478081-73-1
2-{4-[(4-Fluorophenyl)sulfonyl]piperazino}-4,6-dimethylnicotinonitrile
CAS 478081-73-1C18H19FN4O2S
2-{4-[(4-Bromophenyl)sulfonyl]piperazino}-4,6-dimethylnicotinonitrile chemical structure, C18H19BrN4O2S, CAS 478081-74-2
2-{4-[(4-Bromophenyl)sulfonyl]piperazino}-4,6-dimethylnicotinonitrile
CAS 478081-74-2C18H19BrN4O2S
N-[4-({4-[4-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}sulfonyl)phenyl]acetamide chemical structure, C18H19F3N4O3S, CAS 883031-24-1
N-[4-({4-[4-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}sulfonyl)phenyl]acetamide
CAS 883031-24-1C18H19F3N4O3S