Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 3 rings and 20 atoms

70 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 70
With full pages: 30

Scaffold SMILES

O=c1ccoc(CN2CCN(c3ccccc3)CC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1ccoc(CN2CCN(c3ccccc3)CC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

3-Hydroxy-6-(hydroxymethyl)-2-[(4-phenylpiperazinyl)methyl]pyran-4-one chemical structure, C17H20N2O4, CAS 303033-62-7

3-Hydroxy-6-(hydroxymethyl)-2-[(4-phenylpiperazinyl)methyl]pyran-4-one

CAS 303033-62-7C₁₇H₂₀N₂O₄

3-Hydroxy-6-(hydroxymethyl)-2-{[4-(4-methoxyphenyl)piperazino]methyl}-4H-pyran-4-one chemical structure, C18H22N2O5, CAS 866019-45-6

3-Hydroxy-6-(hydroxymethyl)-2-{[4-(4-methoxyphenyl)piperazino]methyl}-4H-pyran-4-one

CAS 866019-45-6C₁₈H₂₂N₂O₅

3-Hydroxy-6-(hydroxymethyl)-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)-4H-pyran-4-one chemical structure, C18H19F3N2O4, CAS 866019-50-3

3-Hydroxy-6-(hydroxymethyl)-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)-4H-pyran-4-one

CAS 866019-50-3C₁₈H₁₉F₃N₂O₄

2-{[4-(2,3-Dimethylphenyl)piperazino]methyl}-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one chemical structure, C19H24N2O4, CAS 866019-59-2

2-{[4-(2,3-Dimethylphenyl)piperazino]methyl}-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

CAS 866019-59-2C₁₉H₂₄N₂O₄

2-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-5-(prop-2-yn-1-yloxy)-4H-pyran-4-one chemical structure, C19H19ClN2O3, CAS 898464-71-6

2-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-5-(prop-2-yn-1-yloxy)-4H-pyran-4-one

CAS 898464-71-6C₁₉H₁₉ClN₂O₃

2-[4-Oxo-6-[(4-phenylpiperazin-1-yl)methyl]pyran-3-yl]oxyacetamide chemical structure, C18H21N3O4, CAS 898455-66-8

2-[4-Oxo-6-[(4-phenylpiperazin-1-yl)methyl]pyran-3-yl]oxyacetamide

CAS 898455-66-8C₁₈H₂₁N₃O₄

2-((6-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide chemical structure, C18H20FN3O4, CAS 898440-44-3

2-((6-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide

CAS 898440-44-3C₁₈H₂₀FN₃O₄

2-((6-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide chemical structure, C18H20ClN3O4, CAS 898416-84-7

2-((6-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide

CAS 898416-84-7C₁₈H₂₀ClN₃O₄

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide chemical structure, C19H23N3O5, CAS 898455-69-1

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetamide

CAS 898455-69-1C₁₉H₂₃N₃O₅

N,N-Diethyl-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide chemical structure, C22H29N3O4, CAS 898456-72-9

N,N-Diethyl-2-((4-oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetamide

CAS 898456-72-9C₂₂H₂₉N₃O₄

N,N-Diethyl-2-[(6-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetamide chemical structure, C22H28FN3O4, CAS 898441-64-0

N,N-Diethyl-2-[(6-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetamide

CAS 898441-64-0C₂₂H₂₈FN₃O₄

N,N-Diethyl-2-[(6-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetamide chemical structure, C22H28FN3O4, CAS 898418-11-6

N,N-Diethyl-2-[(6-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetamide

CAS 898418-11-6C₂₂H₂₈FN₃O₄

Methyl 2-[6-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetate chemical structure, C19H21ClN2O5, CAS 898418-34-3

Methyl 2-[6-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetate

CAS 898418-34-3C₁₉H₂₁ClN₂O₅

Ethyl 2-[4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]pyran-3-yl]oxyacetate chemical structure, C20H24N2O5, CAS 898456-96-7

Ethyl 2-[4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]pyran-3-yl]oxyacetate

CAS 898456-96-7C₂₀H₂₄N₂O₅

Ethyl 2-[(6-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetate chemical structure, C20H23FN2O5, CAS 898442-28-9

Ethyl 2-[(6-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetate

CAS 898442-28-9C₂₀H₂₃FN₂O₅

Ethyl 2-[6-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetate chemical structure, C20H23ClN2O5, CAS 898418-35-4

Ethyl 2-[6-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetate

CAS 898418-35-4C₂₀H₂₃ClN₂O₅

2-((4-Oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetonitrile chemical structure, C18H19N3O3, CAS 898418-36-5

2-((4-Oxo-6-((4-phenylpiperazin-1-yl)methyl)-4H-pyran-3-yl)oxy)acetonitrile

CAS 898418-36-5C₁₈H₁₉N₃O₃

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetonitrile chemical structure, C19H21N3O4, CAS 898442-34-7

2-((6-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-4-oxo-4H-pyran-3-yl)oxy)acetonitrile

CAS 898442-34-7C₁₉H₂₁N₃O₄

2-[(6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetic acid chemical structure, C18H19FN2O5, CAS 898418-37-6

2-[(6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]acetic acid

CAS 898418-37-6C₁₈H₁₉FN₂O₅

2-[6-[[4-(3-Chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetic acid chemical structure, C18H19ClN2O5, CAS 898442-37-0

2-[6-[[4-(3-Chlorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxyacetic acid

CAS 898442-37-0C₁₈H₁₉ClN₂O₅

2-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-5-(2-oxopropoxy)-4H-pyran-4-one chemical structure, C19H21FN2O4, CAS 898442-45-0

2-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-5-(2-oxopropoxy)-4H-pyran-4-one

CAS 898442-45-0C₁₉H₂₁FN₂O₄

N-Methyl-2-({4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-4H-pyran-3-yl}oxy)acetamide chemical structure, C19H23N3O4, CAS 898457-06-2

N-Methyl-2-({4-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-4H-pyran-3-yl}oxy)acetamide

CAS 898457-06-2C₁₉H₂₃N₃O₄

2-[(6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]-N-methylacetamide chemical structure, C19H22FN3O4, CAS 898418-44-5

2-[(6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-4-oxo-4H-pyran-3-yl)oxy]-N-methylacetamide

CAS 898418-44-5C₁₉H₂₂FN₃O₄

2-[6-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxy-N-methylacetamide chemical structure, C19H22FN3O4, CAS 898457-07-3

2-[6-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-4-oxopyran-3-yl]oxy-N-methylacetamide

CAS 898457-07-3C₁₉H₂₂FN₃O₄