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Murcko scaffold

Ring system with 3 rings and 20 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
32
With full pages
13
Scaffold SMILES

S=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

[4-(3-Chlorophenyl)piperazinyl]phenylmethane-1-thione chemical structure, C17H17ClN2S, CAS 327074-66-8
[4-(3-Chlorophenyl)piperazinyl]phenylmethane-1-thione
CAS 327074-66-8C17H17ClN2S
(4-Methoxyphenyl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C18H20N2OS, CAS 307544-84-9
(4-Methoxyphenyl)(4-phenylpiperazin-1-yl)methanethione
CAS 307544-84-9C18H20N2OS
[4-(2-Methylphenyl)piperazin-1-yl]-phenylmethanethione chemical structure, C18H20N2S, CAS 116594-96-8
[4-(2-Methylphenyl)piperazin-1-yl]-phenylmethanethione
CAS 116594-96-8C18H20N2S
(4-(3-Chlorophenyl)piperazin-1-yl)(4-methoxyphenyl)methanethione chemical structure, C18H19ClN2OS, CAS 327074-70-4
(4-(3-Chlorophenyl)piperazin-1-yl)(4-methoxyphenyl)methanethione
CAS 327074-70-4C18H19ClN2OS
[4-(3-Methylphenyl)piperazin-1-yl](phenyl)methanethione chemical structure, C18H20N2S, CAS 116594-97-9
[4-(3-Methylphenyl)piperazin-1-yl](phenyl)methanethione
CAS 116594-97-9C18H20N2S
(4-Dimethylaminophenyl)-(4-phenylpiperazin-1-yl)methanethione chemical structure, C19H23N3S, CAS 327074-60-2
(4-Dimethylaminophenyl)-(4-phenylpiperazin-1-yl)methanethione
CAS 327074-60-2C19H23N3S
(4-(Dimethylamino)phenyl)(4-(m-tolyl)piperazin-1-yl)methanethione chemical structure, C20H25N3S, CAS 314260-02-1
(4-(Dimethylamino)phenyl)(4-(m-tolyl)piperazin-1-yl)methanethione
CAS 314260-02-1C20H25N3S
[4-(Dimethylamino)phenyl][4-(2-methylphenyl)piperazin-1-yl]methanethione chemical structure, C20H25N3S, CAS 314260-01-0
[4-(Dimethylamino)phenyl][4-(2-methylphenyl)piperazin-1-yl]methanethione
CAS 314260-01-0C20H25N3S
[4-(3-Chlorophenyl)piperazin-1-yl](2-hydroxyphenyl)methanethione chemical structure, C17H17ClN2OS, CAS 585561-70-2
[4-(3-Chlorophenyl)piperazin-1-yl](2-hydroxyphenyl)methanethione
CAS 585561-70-2C17H17ClN2OS
4-[4-(2-Fluorophenyl)piperazin-4-ium-1-carbothioyl]-2-methoxyphenolate chemical structure, C18H19FN2O2S, CAS 587012-65-5
4-[4-(2-Fluorophenyl)piperazin-4-ium-1-carbothioyl]-2-methoxyphenolate
CAS 587012-65-5C18H19FN2O2S
4-[4-(2-Fluorophenyl)piperazin-4-ium-1-carbothioyl]phenolate chemical structure, C17H17FN2OS, CAS 694507-03-4
4-[4-(2-Fluorophenyl)piperazin-4-ium-1-carbothioyl]phenolate
CAS 694507-03-4C17H17FN2OS
(4-(4-Fluorophenyl)-1-piperazinyl)phenylmethanethione chemical structure, C17H17FN2S, CAS 451487-21-1
(4-(4-Fluorophenyl)-1-piperazinyl)phenylmethanethione
CAS 451487-21-1C17H17FN2S
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione chemical structure, C17H16FN3O2S, CAS 694516-91-1
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione
CAS 694516-91-1C17H16FN3O2S
[4-(4-Fluorophenyl)piperazin-1-yl]-(4-nitrophenyl)methanethione chemical structure, C17H16FN3O2S, CAS 701237-37-8
[4-(4-Fluorophenyl)piperazin-1-yl]-(4-nitrophenyl)methanethione
CAS 701237-37-8C17H16FN3O2S
4-[4-(4-Fluorophenyl)piperazin-4-ium-1-carbothioyl]phenolate chemical structure, C17H17FN2OS, CAS 573931-01-8
4-[4-(4-Fluorophenyl)piperazin-4-ium-1-carbothioyl]phenolate
CAS 573931-01-8C17H17FN2OS
4-{[4-(3-Chlorophenyl)-1-piperazinyl]carbonothioyl}phenol chemical structure, C17H17ClN2OS, CAS 573931-39-2
4-{[4-(3-Chlorophenyl)-1-piperazinyl]carbonothioyl}phenol
CAS 573931-39-2C17H17ClN2OS
[4-(4-Fluorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione chemical structure, C17H16FN3O2S, CAS 579444-02-3
[4-(4-Fluorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione
CAS 579444-02-3C17H16FN3O2S
(4-Fluorophenyl)[4-(4-fluorophenyl)piperazin-1-yl]methanethione chemical structure, C17H16F2N2S, CAS 701218-63-5
(4-Fluorophenyl)[4-(4-fluorophenyl)piperazin-1-yl]methanethione
CAS 701218-63-5C17H16F2N2S
[4-(2-Fluorophenyl)piperazin-1-yl](4-methylphenyl)methanethione chemical structure, C18H19FN2S, CAS 701240-11-1
[4-(2-Fluorophenyl)piperazin-1-yl](4-methylphenyl)methanethione
CAS 701240-11-1C18H19FN2S
(2-Ethoxyphenyl)[4-(2-fluorophenyl)piperazin-1-yl]methanethione chemical structure, C19H21FN2OS, CAS 708242-08-4
(2-Ethoxyphenyl)[4-(2-fluorophenyl)piperazin-1-yl]methanethione
CAS 708242-08-4C19H21FN2OS
[4-(4-Fluorophenyl)piperazin-1-yl](2-hydroxyphenyl)methanethione chemical structure, C17H17FN2OS, CAS 701223-91-8
[4-(4-Fluorophenyl)piperazin-1-yl](2-hydroxyphenyl)methanethione
CAS 701223-91-8C17H17FN2OS
(4-(3-Chlorophenyl)piperazin-1-yl)(4-(dimethylamino)phenyl)methanethione chemical structure, C19H22ClN3S, CAS 327074-68-0
(4-(3-Chlorophenyl)piperazin-1-yl)(4-(dimethylamino)phenyl)methanethione
CAS 327074-68-0C19H22ClN3S
(2,5-Dimethoxyphenyl)[4-(4-methoxyphenyl)piperazin-1-yl]methanethione chemical structure, C20H24N2O3S, CAS 714214-24-1
(2,5-Dimethoxyphenyl)[4-(4-methoxyphenyl)piperazin-1-yl]methanethione
CAS 714214-24-1C20H24N2O3S
[4-(3-Chlorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione chemical structure, C17H16ClN3O2S, CAS 694508-07-1
[4-(3-Chlorophenyl)piperazin-1-yl]-(3-nitrophenyl)methanethione
CAS 694508-07-1C17H16ClN3O2S