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Murcko scaffold

Piperazine, 1-benzyl-4-(2-pyridyl)- scaffold

96 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
96
With full pages
12
Scaffold SMILES

c1ccc(CN2CCN(c3ccccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-benzyl-4-(2-pyridyl)- page
Murcko scaffold c1ccc(CN2CCN(c3ccccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 96 chemicals

Piperazine, 1-(3,4-dimethoxybenzyl)-4-(2-pyridyl)- chemical structure, C18H23N3O2, CAS 63978-40-5
Piperazine, 1-(3,4-dimethoxybenzyl)-4-(2-pyridyl)-
CAS 63978-40-5C18H23N3O2
Piperazine, 1-benzyl-4-(2-pyridyl)- chemical structure, C16H19N3, CAS 63980-42-7
Piperazine, 1-benzyl-4-(2-pyridyl)-
CAS 63980-42-7C16H19N3
1-(4-Methoxy-3,5-dimethylbenzyl)-4-(3-(ethylamino)-2-pyridyl)piperazine hydrochloride chemical structure, C21H31ClN4O, CAS 136818-99-0
1-(4-Methoxy-3,5-dimethylbenzyl)-4-(3-(ethylamino)-2-pyridyl)piperazine hydrochloride
CAS 136818-99-0C21H31ClN4O
1-(4-Methoxy-3,5-dimethylbenzyl)-4-(3-(ethylamino)-2-pyridyl)piperazine chemical structure, C21H30N4O, CAS 136816-67-6
1-(4-Methoxy-3,5-dimethylbenzyl)-4-(3-(ethylamino)-2-pyridyl)piperazine
CAS 136816-67-6C21H30N4O
Phenol, 4-((4-(3-(ethylamino)-2-pyridinyl)-1-piperazinyl)methyl)-2,6-dimethyl- chemical structure, C20H28N4O, CAS 136816-68-7
Phenol, 4-((4-(3-(ethylamino)-2-pyridinyl)-1-piperazinyl)methyl)-2,6-dimethyl-
CAS 136816-68-7C20H28N4O
1-[4-Methoxy-3,5-dimethylbenzyl]-4-[3-(2-propenylamino)-2-pyridinyl]piperazine chemical structure, C22H30N4O, CAS 136831-14-6
1-[4-Methoxy-3,5-dimethylbenzyl]-4-[3-(2-propenylamino)-2-pyridinyl]piperazine
CAS 136831-14-6C22H30N4O
1-Benzyl-4-(5-(trifluoromethyl)-pyridin-2-yl)piperazine chemical structure, C17H18F3N3, CAS 402946-95-6
1-Benzyl-4-(5-(trifluoromethyl)-pyridin-2-yl)piperazine
CAS 402946-95-6C17H18F3N3
1-[(4-Fluorophenyl)methyl]-4-pyridin-2-ylpiperazine chemical structure, C16H18FN3, CAS 414873-83-9
1-[(4-Fluorophenyl)methyl]-4-pyridin-2-ylpiperazine
CAS 414873-83-9C16H18FN3
1-[(4-Methoxy-3-methylphenyl)methyl]-4-pyridin-2-ylpiperazine chemical structure, C18H23N3O, CAS 331856-27-0
1-[(4-Methoxy-3-methylphenyl)methyl]-4-pyridin-2-ylpiperazine
CAS 331856-27-0C18H23N3O
2-Methoxy-5-[(4-pyridin-2-ylpiperazin-1-ium-1-yl)methyl]phenolate chemical structure, C17H21N3O2, CAS 376624-03-2
2-Methoxy-5-[(4-pyridin-2-ylpiperazin-1-ium-1-yl)methyl]phenolate
CAS 376624-03-2C17H21N3O2
2-(4-Benzylpiperazin-1-yl)-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile chemical structure, C20H24N4O, CAS 384372-93-4
2-(4-Benzylpiperazin-1-yl)-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
CAS 384372-93-4C20H24N4O
2-[4-(4-Chlorobenzyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile chemical structure, C19H21ClN4, CAS 718600-45-4
2-[4-(4-Chlorobenzyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile
CAS 718600-45-4C19H21ClN4
2,2,2-Trifluoroethyl 6-(4-benzylpiperazino)nicotinate chemical structure, C19H20F3N3O2, CAS 339011-45-9
2,2,2-Trifluoroethyl 6-(4-benzylpiperazino)nicotinate
CAS 339011-45-9C19H20F3N3O2
1-Benzyl-4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine chemical structure, C17H17ClF3N3, CAS 676624-85-4
1-Benzyl-4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine
CAS 676624-85-4C17H17ClF3N3
2-(4-Benzylpiperazino)nicotinaldehyde chemical structure, C17H19N3O, CAS 885949-58-6
2-(4-Benzylpiperazino)nicotinaldehyde
CAS 885949-58-6C17H19N3O
6-(4-Benzylpiperazino)nicotinaldehyde chemical structure, C17H19N3O, CAS 886360-69-6
6-(4-Benzylpiperazino)nicotinaldehyde
CAS 886360-69-6C17H19N3O
6-(4-Benzylpiperazino)nicotinic acid chemical structure, C17H19N3O2, CAS 886360-80-1
6-(4-Benzylpiperazino)nicotinic acid
CAS 886360-80-1C17H19N3O2
Methyl 6-(4-benzylpiperazino)nicotinate chemical structure, C18H21N3O2, CAS 132521-74-5
Methyl 6-(4-benzylpiperazino)nicotinate
CAS 132521-74-5C18H21N3O2
1-Benzyl-4-(3-nitropyridin-2-yl)piperazine chemical structure, C16H18N4O2, CAS 499771-07-2
1-Benzyl-4-(3-nitropyridin-2-yl)piperazine
CAS 499771-07-2C16H18N4O2
2-Methoxy-4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenol chemical structure, C17H21N3O2, CAS 5260-83-3
2-Methoxy-4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenol
CAS 5260-83-3C17H21N3O2
1-Benzyl-4-(5-nitropyridin-2-yl)piperazine chemical structure, C16H18N4O2, CAS 381706-35-0
1-Benzyl-4-(5-nitropyridin-2-yl)piperazine
CAS 381706-35-0C16H18N4O2
2-(4-Benzylpiperazin-1-yl)-4,6-dimethylpyridine-3-carbonitrile chemical structure, C19H22N4, CAS 831177-02-7
2-(4-Benzylpiperazin-1-yl)-4,6-dimethylpyridine-3-carbonitrile
CAS 831177-02-7C19H22N4
Propan-2-yl 2-(4-benzylpiperazin-1-yl)pyridine-3-carboxylate chemical structure, C20H25N3O2, CAS 338792-73-7
Propan-2-yl 2-(4-benzylpiperazin-1-yl)pyridine-3-carboxylate
CAS 338792-73-7C20H25N3O2
4-[(4-(2-Pyridyl)piperazinyl)methyl]benzenecarbonitrile chemical structure, C17H18N4, CAS 871807-40-8
4-[(4-(2-Pyridyl)piperazinyl)methyl]benzenecarbonitrile
CAS 871807-40-8C17H18N4