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Murcko scaffold

Ring system with 3 rings and 23 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
20
With full pages
14
Scaffold SMILES

O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

1,3,6-Trimethyl-5-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylpyrimidine-2,4-dione chemical structure, C18H21F3N4O4S, CAS 893339-21-4
1,3,6-Trimethyl-5-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylpyrimidine-2,4-dione
CAS 893339-21-4C18H21F3N4O4S
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H19FN4O4S, CAS 874806-22-1
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 874806-22-1C16H19FN4O4S
5-[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H19FN4O4S, CAS 874806-42-5
5-[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 874806-42-5C16H19FN4O4S
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C17H22N4O5S, CAS 874806-50-5
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 874806-50-5C17H22N4O5S
5-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H19ClN4O4S, CAS 874806-70-9
5-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 874806-70-9C16H19ClN4O4S
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione chemical structure, C17H21FN4O4S, CAS 893337-24-1
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione
CAS 893337-24-1C17H21FN4O4S
5-[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione chemical structure, C17H21FN4O4S, CAS 893339-57-6
5-[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione
CAS 893339-57-6C17H21FN4O4S
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione chemical structure, C18H24N4O5S, CAS 887224-62-6
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione
CAS 887224-62-6C18H24N4O5S
5-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione chemical structure, C17H21ClN4O4S, CAS 893343-26-5
5-[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3,6-trimethylpyrimidine-2,4-dione
CAS 893343-26-5C17H21ClN4O4S
1,3,6-Trimethyl-5-((4-phenylpiperazin-1-yl)sulfonyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C17H22N4O4S, CAS 893343-76-5
1,3,6-Trimethyl-5-((4-phenylpiperazin-1-yl)sulfonyl)pyrimidine-2,4(1H,3H)-dione
CAS 893343-76-5C17H22N4O4S
6-Amino-1,3-dimethyl-5-(4-phenylpiperazin-1-yl)sulfonylpyrimidine-2,4-dione chemical structure, C16H21N5O4S, CAS 869076-77-7
6-Amino-1,3-dimethyl-5-(4-phenylpiperazin-1-yl)sulfonylpyrimidine-2,4-dione
CAS 869076-77-7C16H21N5O4S
6-Amino-5-[4-(2-chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H20ClN5O4S, CAS 893377-99-6
6-Amino-5-[4-(2-chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 893377-99-6C16H20ClN5O4S
6-Amino-5-[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H20ClN5O4S, CAS 869076-80-2
6-Amino-5-[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 869076-80-2C16H20ClN5O4S
6-Amino-5-[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione chemical structure, C16H20FN5O4S, CAS 869076-81-3
6-Amino-5-[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl-1,3-dimethylpyrimidine-2,4-dione
CAS 869076-81-3C16H20FN5O4S
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione chemical structure, C15H18N4O5S, CAS 897622-66-1
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione
CAS 897622-66-1C15H18N4O5S
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione chemical structure, C14H15FN4O4S, CAS 897622-86-5
5-[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione
CAS 897622-86-5C14H15FN4O4S
5-[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione chemical structure, C15H18N4O5S, CAS 897622-95-6
5-[4-(2-Methoxyphenyl)piperazin-1-yl]sulfonyl-1H-pyrimidine-2,4-dione
CAS 897622-95-6C15H18N4O5S
1,3-Dimethyl-5-(4-phenylpiperazino)sulfonyl-pyrimidine-2,4-quinone chemical structure, C16H20N4O4S, CAS 874806-76-5
1,3-Dimethyl-5-(4-phenylpiperazino)sulfonyl-pyrimidine-2,4-quinone
CAS 874806-76-5C16H20N4O4S
5-((4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)pyrimidine-2,4(1H,3H)-dione chemical structure, C15H15F3N4O4S, CAS 897622-87-6
5-((4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)pyrimidine-2,4(1H,3H)-dione
CAS 897622-87-6C15H15F3N4O4S
6-Amino-5-((4-(2-methoxyphenyl)piperazin-1-yl)sulfonyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione chemical structure, C17H23N5O5S, CAS 893378-28-4
6-Amino-5-((4-(2-methoxyphenyl)piperazin-1-yl)sulfonyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
CAS 893378-28-4C17H23N5O5S