Murcko scaffold
2,5-Diazaspiro[3.4]octane scaffold
72 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 72
- With full pages
- 5
Scaffold SMILES
C1CNC2(C1)CNC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 72 chemicals
![2,5-Diazaspiro[3.4]octane chemical structure, C6H12N2, CAS 36328-14-0](/s/DAHLUHBOWUHHOX-UHFFFAOYSA-N.svg)
2,5-Diazaspiro[3.4]octane
CAS 36328-14-0C6H12N2
![tert-Butyl 2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H20N2O2, CAS 1086398-04-0](/s/XKASCTCECDLMSI-UHFFFAOYSA-N.svg)
tert-Butyl 2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 1086398-04-0C11H20N2O2
![tert-Butyl 2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C11H20N2O2, CAS 1086398-02-8](/s/YSRVDGYYECHRCC-UHFFFAOYSA-N.svg)
tert-Butyl 2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 1086398-02-8C11H20N2O2
![5-Pentyl-2,5-diazaspiro[3.4]octane chemical structure, C11H22N2, CAS 2166759-38-0](/s/LBFSLROOGRMJAR-UHFFFAOYSA-N.svg)
5-Pentyl-2,5-diazaspiro[3.4]octane
CAS 2166759-38-0C11H22N2
![2-Methyl-2,5-diazaspiro[3.4]octane chemical structure, C7H14N2, CAS 1824297-43-9](/s/YXOXXNWKGSCEMM-UHFFFAOYSA-N.svg)
2-Methyl-2,5-diazaspiro[3.4]octane
CAS 1824297-43-9C7H14N2
![5-Methyl-2,5-diazaspiro[3.4]octane dihydrochloride chemical structure, C7H16Cl2N2, CAS 1421372-18-0](/s/PQYDVGREOGKEKD-UHFFFAOYSA-N.svg)
5-Methyl-2,5-diazaspiro[3.4]octane dihydrochloride
CAS 1421372-18-0C7H16Cl2N2
![5-Methyl-2,5-diazaspiro[3.4]octane chemical structure, C7H14N2, CAS 1421374-01-7](/s/GMRSNDRXDYVEAG-UHFFFAOYSA-N.svg)
5-Methyl-2,5-diazaspiro[3.4]octane
CAS 1421374-01-7C7H14N2
![2-Boc-2,5-diazaspiro[3.4]octane oxalate chemical structure, C13H22N2O6, CAS 1359655-69-8](/s/CKDFXVYACWODKL-UHFFFAOYSA-N.svg)
2-Boc-2,5-diazaspiro[3.4]octane oxalate
CAS 1359655-69-8C13H22N2O6
![tert-Butyl 2,5-diazaspiro[3.4]octane-2-carboxylate hemioxalate chemical structure, C24H42N4O8, CAS 1523618-32-7](/s/VEXZHLKGHDJPOX-UHFFFAOYSA-N.svg)
tert-Butyl 2,5-diazaspiro[3.4]octane-2-carboxylate hemioxalate
CAS 1523618-32-7C24H42N4O8
![tert-Butyl 2,5-diazaspiro[3.4]octane-5-carboxylate hemioxalate chemical structure, C24H42N4O8, CAS 1630906-60-3](/s/HAGQSTKTUAYTMX-UHFFFAOYSA-N.svg)
tert-Butyl 2,5-diazaspiro[3.4]octane-5-carboxylate hemioxalate
CAS 1630906-60-3C24H42N4O8
![Di-tert-butyl 2,5-diazaspiro[3.4]octane-2,5-dicarboxylate chemical structure, C16H28N2O4, CAS 1936635-16-3](/s/VTNOJNHBTJTXCV-UHFFFAOYSA-N.svg)
Di-tert-butyl 2,5-diazaspiro[3.4]octane-2,5-dicarboxylate
CAS 1936635-16-3C16H28N2O4
![2,5-Diaza-spiro[3.4]octane-5-carboxylic acid tert-butyl ester oxalate chemical structure, C13H22N2O6, CAS 1359655-85-8](/s/OYVDREJBJQMATQ-UHFFFAOYSA-N.svg)
2,5-Diaza-spiro[3.4]octane-5-carboxylic acid tert-butyl ester oxalate
CAS 1359655-85-8C13H22N2O6
![tert-Butyl 7-(hydroxymethyl)-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O3, CAS 1936549-36-8](/s/DSXNGLJYROKFQX-UHFFFAOYSA-N.svg)
tert-Butyl 7-(hydroxymethyl)-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 1936549-36-8C12H22N2O3
![tert-Butyl 7-(hydroxymethyl)-5-methyl-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C13H24N2O3, CAS 1936640-94-6](/s/AHACRNPJDINPQJ-UHFFFAOYSA-N.svg)
tert-Butyl 7-(hydroxymethyl)-5-methyl-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 1936640-94-6C13H24N2O3
![tert-Butyl 1-(propan-2-yl)-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C14H26N2O2, CAS 2169493-61-0](/s/WJCNSNPJLILBHV-UHFFFAOYSA-N.svg)
tert-Butyl 1-(propan-2-yl)-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 2169493-61-0C14H26N2O2
![2-(tert-Butyl) 8-ethyl 2,5-diazaspiro[3.4]octane-2,8-dicarboxylate chemical structure, C14H24N2O4, CAS 2089651-98-7](/s/ZCHIWSXHQCAQIY-UHFFFAOYSA-N.svg)
2-(tert-Butyl) 8-ethyl 2,5-diazaspiro[3.4]octane-2,8-dicarboxylate
CAS 2089651-98-7C14H24N2O4
![tert-Butyl 5-[2-(N-ethylprop-2-enamido)acetyl]-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C18H29N3O4, CAS 2361765-22-0](/s/QBCVCGJWRFMPOG-UHFFFAOYSA-N.svg)
tert-Butyl 5-[2-(N-ethylprop-2-enamido)acetyl]-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 2361765-22-0C18H29N3O4
![5-(Propan-2-yl)-2,5-diazaspiro[3.4]octane chemical structure, C9H18N2, CAS 2167527-52-6](/s/LQGNUOBBEAFQCI-UHFFFAOYSA-N.svg)
5-(Propan-2-yl)-2,5-diazaspiro[3.4]octane
CAS 2167527-52-6C9H18N2
![tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-2-carboxylate hydrochloride chemical structure, C11H21ClN2O3, CAS 2460755-22-8](/s/SNMVONZNXNCWCM-UHFFFAOYSA-N.svg)
tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-2-carboxylate hydrochloride
CAS 2460755-22-8C11H21ClN2O3
![tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C11H20N2O3, CAS 2306262-34-8](/s/VBEPRGVZKBMFPM-UHFFFAOYSA-N.svg)
tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 2306262-34-8C11H20N2O3
![5-(2-Methoxyethyl)-2,5-diazaspiro[3.4]octane dihydrochloride chemical structure, C9H20Cl2N2O, CAS 2551116-66-4](/s/YMQAPPYOWZUHLQ-UHFFFAOYSA-N.svg)
5-(2-Methoxyethyl)-2,5-diazaspiro[3.4]octane dihydrochloride
CAS 2551116-66-4C9H20Cl2N2O
![5-(2-Methoxyethyl)-2,5-diazaspiro[3.4]octane chemical structure, C9H18N2O, CAS 2168568-64-5](/s/SBGOUEPNOLRXHW-UHFFFAOYSA-N.svg)
5-(2-Methoxyethyl)-2,5-diazaspiro[3.4]octane
CAS 2168568-64-5C9H18N2O
![tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H20N2O3, CAS 2306263-82-9](/s/KJBRUIDXDBAZHO-UHFFFAOYSA-N.svg)
tert-Butyl 7-hydroxy-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306263-82-9C11H20N2O3
![tert-Butyl 7-fluoro-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H19FN2O2, CAS 2306265-68-7](/s/YLDIHCUJPUQQIA-UHFFFAOYSA-N.svg)
tert-Butyl 7-fluoro-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306265-68-7C11H19FN2O2
- tert-Butyl 7-fluoro-2,5-diazaspiro[3.4]octane-2-carboxylate2306278-49-7C11H19FN2O2
- tert-Butyl 7,7-difluoro-2,5-diazaspiro[3.4]octane-2-carboxylate2306271-45-2C11H18F2N2O2
- 2-Methyl-2,5-diazaspiro[3.4]octane dihydrochloride2805804-17-3C7H16Cl2N2
- 5-Propyl-2,5-diazaspiro[3.4]octane2166722-41-2C9H18N2
- 5-(2-Methylpropyl)-2,5-diazaspiro[3.4]octane2167167-01-1C10H20N2
- tert-Butyl 8-amino-5-propyl-2,5-diazaspiro[3.4]octane-2-carboxylate2137451-03-5C14H27N3O2
- tert-Butyl 8-amino-5-(propan-2-yl)-2,5-diazaspiro[3.4]octane-2-carboxylate2137488-91-4C14H27N3O2
- tert-Butyl 8-amino-5-ethyl-2,5-diazaspiro[3.4]octane-2-carboxylate2137489-53-1C13H25N3O2
- (3-{2,5-Diazaspiro[3.4]octan-5-yl}propyl)dimethylamine2169636-14-8C11H23N3
- 5-{2,5-Diazaspiro[3.4]octan-5-yl}pentanenitrile2169567-99-9C11H19N3
- 5-(3-Methylbutyl)-2,5-diazaspiro[3.4]octane2167816-65-9C11H22N2
- 5-(2,2,2-Trifluoroethyl)-2,5-diazaspiro[3.4]octane2166965-65-5C8H13F3N2
- 5-(3-Methoxy-2-methylpropyl)-2,5-diazaspiro[3.4]octane2166990-04-9C11H22N2O
- 5-(3-Fluoropropyl)-2,5-diazaspiro[3.4]octane2167984-85-0C9H17FN2
- 5-(Pentan-3-yl)-2,5-diazaspiro[3.4]octane2167807-93-2C11H22N2
- 5-(2-Methanesulfonylethyl)-2,5-diazaspiro[3.4]octane2169519-22-4C9H18N2O2S
- 5-(1,1,1-Trifluoropropan-2-yl)-2,5-diazaspiro[3.4]octane2167379-51-1C9H15F3N2
- (2-{2,5-Diazaspiro[3.4]octan-5-yl}ethyl)dimethylamine2166877-84-3C10H21N3
- 2,5-Diazaspiro[3.4]octane, bis(trifluoroacetic acid)2803861-60-9C10H14F6N2O4
- tert-Butyl 7-(dimethylamino)-2,5-diazaspiro[3.4]octane-2-carboxylate2287267-91-6C13H25N3O2
- 5-(3-Methoxypropyl)-2,5-diazaspiro[3.4]octane2167414-17-5C10H20N2O
- 5-(3-Methylbutan-2-yl)-2,5-diazaspiro[3.4]octane2168707-45-5C11H22N2
- 5-(Butan-2-yl)-2,5-diazaspiro[3.4]octane2168708-40-3C10H20N2
- 5-(1-Methoxypropan-2-yl)-2,5-diazaspiro[3.4]octane2168259-11-6C10H20N2O
Related scaffolds
Same ring framework with different atoms or bond orders
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C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
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