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Murcko scaffold

Ring system with 3 rings and 21 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
29
With full pages
2
Scaffold SMILES

O=C1C(=Cc2ccccc2)SC(=S)N1C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)SC(=S)N1C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-ethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H17NO4S3, CAS 519034-48-1
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-ethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 519034-48-1C16H17NO4S3
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H15NO4S3, CAS 519033-82-0
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 519033-82-0C15H15NO4S3
(5Z)-5-(4-tert-Butylbenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H21NO3S3, CAS 519033-85-3
(5Z)-5-(4-tert-Butylbenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 519033-85-3C18H21NO3S3
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H11ClFNO3S3, CAS 519033-84-2
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 519033-84-2C14H11ClFNO3S3
(5Z)-5-(3,5-di-tert-Butyl-4-hydroxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C22H29NO4S3, CAS 510766-23-1
(5Z)-5-(3,5-di-tert-Butyl-4-hydroxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 510766-23-1C22H29NO4S3
5-(2-Chlorobenzylidene)-3-(1,1-dioxidotetrahydro-3-thienyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H12ClNO3S3, CAS 324565-48-2
5-(2-Chlorobenzylidene)-3-(1,1-dioxidotetrahydro-3-thienyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-48-2C14H12ClNO3S3
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H12FNO3S3, CAS 324544-14-1
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 324544-14-1C14H12FNO3S3
RefChem:314111 chemical structure, C15H15NO5S3, CAS 5862-71-5
RefChem:314111
CAS 5862-71-5C15H15NO5S3
(Z)-5-(2,4-Dichlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one chemical structure, C14H11Cl2NO3S3, CAS 302934-40-3
(Z)-5-(2,4-Dichlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one
CAS 302934-40-3C14H11Cl2NO3S3
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H15NO4S3, CAS 324565-96-0
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-96-0C15H15NO4S3
(5Z)-5-Benzylidene-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H13NO3S3, CAS 305856-00-2
(5Z)-5-Benzylidene-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 305856-00-2C14H13NO3S3
(Z)-5-(4-Chlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one chemical structure, C14H12ClNO3S3, CAS 302824-20-0
(Z)-5-(4-Chlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one
CAS 302824-20-0C14H12ClNO3S3
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-one chemical structure, C14H13NO4S3, CAS 302934-46-9
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-one
CAS 302934-46-9C14H13NO4S3
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-nitrobenzylidene)-2-thioxothiazolidin-4-one chemical structure, C14H12N2O5S3, CAS 302934-35-6
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-nitrobenzylidene)-2-thioxothiazolidin-4-one
CAS 302934-35-6C14H12N2O5S3
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-methylbenzylidene)-2-thioxothiazolidin-4-one chemical structure, C15H15NO3S3, CAS 302934-34-5
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-methylbenzylidene)-2-thioxothiazolidin-4-one
CAS 302934-34-5C15H15NO3S3
(Z)-5-(4-(Dimethylamino)benzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one chemical structure, C16H18N2O3S3, CAS 302934-33-4
(Z)-5-(4-(Dimethylamino)benzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one
CAS 302934-33-4C16H18N2O3S3
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-fluorobenzylidene)-2-thioxothiazolidin-4-one chemical structure, C14H12FNO3S3, CAS 306279-30-1
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(2-fluorobenzylidene)-2-thioxothiazolidin-4-one
CAS 306279-30-1C14H12FNO3S3
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-methoxybenzylidene)-2-thioxothiazolidin-4-one chemical structure, C15H15NO4S3, CAS 302934-38-9
(Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-(4-methoxybenzylidene)-2-thioxothiazolidin-4-one
CAS 302934-38-9C15H15NO4S3
(Z)-5-(3,4-Dimethoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one chemical structure, C16H17NO5S3, CAS 302934-47-0
(Z)-5-(3,4-Dimethoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one
CAS 302934-47-0C16H17NO5S3
(5E)-3-(1,1-Dioxothiolan-3-yl)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C16H17NO3S3, CAS 383372-07-4
(5E)-3-(1,1-Dioxothiolan-3-yl)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 383372-07-4C16H17NO3S3
(5Z)-5-(4-Butoxy-3-ethoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H25NO5S3, CAS 608120-97-4
(5Z)-5-(4-Butoxy-3-ethoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 608120-97-4C20H25NO5S3
(5Z)-5-(3-Chlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H12ClNO3S3, CAS 373612-33-0
(5Z)-5-(3-Chlorobenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxo-1,3-thiazolidin-4-one
CAS 373612-33-0C14H12ClNO3S3
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-[3-methoxy-4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H19NO5S3, CAS 797014-68-7
(5Z)-3-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-[3-methoxy-4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 797014-68-7C18H19NO5S3
(Z)-5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one chemical structure, C15H14BrNO5S3, CAS 616213-98-0
(Z)-5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-3-(1,1-dioxidotetrahydrothiophen-3-yl)-2-thioxothiazolidin-4-one
CAS 616213-98-0C15H14BrNO5S3