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Murcko scaffold

Ring system with 3 rings and 19 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
8
With full pages
3
Scaffold SMILES

O=C1CC(Sc2ccccc2)C(=O)N1c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(Sc2ccccc2)C(=O)N1c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

2-((1-(3-(Methoxycarbonyl)-4,5-dimethylthiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid chemical structure, C19H17NO6S2, CAS 512838-49-2
2-((1-(3-(Methoxycarbonyl)-4,5-dimethylthiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid
CAS 512838-49-2C19H17NO6S2
2-({1-[3-(Ethoxycarbonyl)-5-ethyl-2-thienyl]-2,5-dioxo-3-pyrrolidinyl}thio)benzoic acid chemical structure, C20H19NO6S2, CAS 685130-29-4
2-({1-[3-(Ethoxycarbonyl)-5-ethyl-2-thienyl]-2,5-dioxo-3-pyrrolidinyl}thio)benzoic acid
CAS 685130-29-4C20H19NO6S2
2-((1-(3-(Methoxycarbonyl)-5-methylthiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid chemical structure, C18H15NO6S2, CAS 831228-85-4
2-((1-(3-(Methoxycarbonyl)-5-methylthiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid
CAS 831228-85-4C18H15NO6S2
2-({1-[3-(Ethoxycarbonyl)-4,5-dimethylthiophen-2-yl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)benzoic acid chemical structure, C20H19NO6S2, CAS 303033-65-0
2-({1-[3-(Ethoxycarbonyl)-4,5-dimethylthiophen-2-yl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)benzoic acid
CAS 303033-65-0C20H19NO6S2
Ethyl 5-ethyl-2-(3-{[2-(methoxycarbonyl)phenyl]sulfanyl}-2,5-dioxopyrrolidin-1-yl)thiophene-3-carboxylate chemical structure, C21H21NO6S2, CAS 887847-91-8
Ethyl 5-ethyl-2-(3-{[2-(methoxycarbonyl)phenyl]sulfanyl}-2,5-dioxopyrrolidin-1-yl)thiophene-3-carboxylate
CAS 887847-91-8C21H21NO6S2
2-((1-(3-(Methoxycarbonyl)thiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid chemical structure, C17H13NO6S2, CAS 881484-69-1
2-((1-(3-(Methoxycarbonyl)thiophen-2-yl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid
CAS 881484-69-1C17H13NO6S2
Methyl 2-(3-{[2-(methoxycarbonyl)phenyl]sulfanyl}-2,5-dioxopyrrolidin-1-yl)thiophene-3-carboxylate chemical structure, C18H15NO6S2, CAS 881485-29-6
Methyl 2-(3-{[2-(methoxycarbonyl)phenyl]sulfanyl}-2,5-dioxopyrrolidin-1-yl)thiophene-3-carboxylate
CAS 881485-29-6C18H15NO6S2
2-({1-[3-(Methoxycarbonyl)-5-propylthiophen-2-yl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)benzoic acid chemical structure, C20H19NO6S2, CAS 924861-11-0
2-({1-[3-(Methoxycarbonyl)-5-propylthiophen-2-yl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)benzoic acid
CAS 924861-11-0C20H19NO6S2