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Murcko scaffold

Ring system with 3 rings and 19 atoms

44 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
44
With full pages
6
Scaffold SMILES

O=S(=O)(c1ccccc1)c1coc(-c2cccs2)n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)c1coc(-c2cccs2)n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

4-((4-Chlorophenyl)sulfonyl)-N-ethyl-2-(thiophen-2-yl)oxazol-5-amine chemical structure, C15H13ClN2O3S2, CAS 627834-59-7
4-((4-Chlorophenyl)sulfonyl)-N-ethyl-2-(thiophen-2-yl)oxazol-5-amine
CAS 627834-59-7C15H13ClN2O3S2
4-(Benzenesulfonyl)-N-methyl-2-thiophen-2-yl-1,3-oxazol-5-amine chemical structure, C14H12N2O3S2, CAS 342433-30-1
4-(Benzenesulfonyl)-N-methyl-2-thiophen-2-yl-1,3-oxazol-5-amine
CAS 342433-30-1C14H12N2O3S2
N-[4-(4-Chlorophenyl)sulfonyl-2-thiophen-2-yl-1,3-oxazol-5-yl]-N',N'-dimethylpropane-1,3-diamine chemical structure, C18H20ClN3O3S2, CAS 627834-83-7
N-[4-(4-Chlorophenyl)sulfonyl-2-thiophen-2-yl-1,3-oxazol-5-yl]-N',N'-dimethylpropane-1,3-diamine
CAS 627834-83-7C18H20ClN3O3S2
4-((4-Chlorophenyl)sulfonyl)-N-(3-methoxypropyl)-2-(thiophen-2-yl)oxazol-5-amine chemical structure, C17H17ClN2O4S2, CAS 627834-73-5
4-((4-Chlorophenyl)sulfonyl)-N-(3-methoxypropyl)-2-(thiophen-2-yl)oxazol-5-amine
CAS 627834-73-5C17H17ClN2O4S2
N-[3-(Dimethylamino)propyl]-N-[4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazol-5-yl]amine chemical structure, C18H21N3O3S2, CAS 7065-29-4
N-[3-(Dimethylamino)propyl]-N-[4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazol-5-yl]amine
CAS 7065-29-4C18H21N3O3S2
5-Ethylthio-4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazole chemical structure, C15H13NO3S3, CAS 850927-55-8
5-Ethylthio-4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazole
CAS 850927-55-8C15H13NO3S3
2-({4-[(4-Methylphenyl)sulfonyl]-2-thien-2-yl-1,3-oxazol-5-yl}thio)acetamide chemical structure, C16H14N2O4S3, CAS 850927-65-0
2-({4-[(4-Methylphenyl)sulfonyl]-2-thien-2-yl-1,3-oxazol-5-yl}thio)acetamide
CAS 850927-65-0C16H14N2O4S3
4-[(4-Methylphenyl)sulfonyl]-5-methylthio-2-(2-thienyl)-1,3-oxazole chemical structure, C15H13NO3S3, CAS 686737-40-6
4-[(4-Methylphenyl)sulfonyl]-5-methylthio-2-(2-thienyl)-1,3-oxazole
CAS 686737-40-6C15H13NO3S3
2-{4-[(4-Fluorophenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-ylthio}acetamide chemical structure, C15H11FN2O4S3, CAS 850927-84-3
2-{4-[(4-Fluorophenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-ylthio}acetamide
CAS 850927-84-3C15H11FN2O4S3
5-(Ethylsulfanyl)-4-(4-fluorobenzenesulfonyl)-2-(thiophen-2-yl)-1,3-oxazole chemical structure, C15H12FNO3S3, CAS 850927-87-6
5-(Ethylsulfanyl)-4-(4-fluorobenzenesulfonyl)-2-(thiophen-2-yl)-1,3-oxazole
CAS 850927-87-6C15H12FNO3S3
2-{4-[(4-Chlorophenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-ylthio}acetamide chemical structure, C15H11ClN2O4S3, CAS 850928-07-3
2-{4-[(4-Chlorophenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-ylthio}acetamide
CAS 850928-07-3C15H11ClN2O4S3
5-(Pentylthio)-2-(thiophen-2-yl)-4-tosyloxazole chemical structure, C19H21NO3S3, CAS 850927-77-4
5-(Pentylthio)-2-(thiophen-2-yl)-4-tosyloxazole
CAS 850927-77-4C19H21NO3S3
4-((4-Fluorophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole chemical structure, C18H18FNO3S3, CAS 850928-00-6
4-((4-Fluorophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole
CAS 850928-00-6C18H18FNO3S3
4-(4-Chlorobenzenesulfonyl)-5-(methylsulfanyl)-2-(thiophen-2-yl)-1,3-oxazole chemical structure, C14H10ClNO3S3, CAS 850928-09-5
4-(4-Chlorobenzenesulfonyl)-5-(methylsulfanyl)-2-(thiophen-2-yl)-1,3-oxazole
CAS 850928-09-5C14H10ClNO3S3
5-(Butylthio)-4-((4-chlorophenyl)sulfonyl)-2-(thiophen-2-yl)oxazole chemical structure, C17H16ClNO3S3, CAS 850928-13-1
5-(Butylthio)-4-((4-chlorophenyl)sulfonyl)-2-(thiophen-2-yl)oxazole
CAS 850928-13-1C17H16ClNO3S3
4-((4-Chlorophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole chemical structure, C18H18ClNO3S3, CAS 850928-23-3
4-((4-Chlorophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole
CAS 850928-23-3C18H18ClNO3S3
4-((4-Bromophenyl)sulfonyl)-5-(methylthio)-2-(thiophen-2-yl)oxazole chemical structure, C14H10BrNO3S3, CAS 850928-32-4
4-((4-Bromophenyl)sulfonyl)-5-(methylthio)-2-(thiophen-2-yl)oxazole
CAS 850928-32-4C14H10BrNO3S3
4-((4-Bromophenyl)sulfonyl)-5-(isobutylthio)-2-(thiophen-2-yl)oxazole chemical structure, C17H16BrNO3S3, CAS 850928-43-7
4-((4-Bromophenyl)sulfonyl)-5-(isobutylthio)-2-(thiophen-2-yl)oxazole
CAS 850928-43-7C17H16BrNO3S3
4-((4-Bromophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole chemical structure, C18H18BrNO3S3, CAS 850928-44-8
4-((4-Bromophenyl)sulfonyl)-5-(pentylthio)-2-(thiophen-2-yl)oxazole
CAS 850928-44-8C18H18BrNO3S3
N-Butyl-4-(phenylsulfonyl)-2-(thiophen-2-yl)oxazol-5-amine chemical structure, C17H18N2O3S2, CAS 627832-78-4
N-Butyl-4-(phenylsulfonyl)-2-(thiophen-2-yl)oxazol-5-amine
CAS 627832-78-4C17H18N2O3S2
N-Allyl-4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazol-5-amine chemical structure, C16H14N2O3S2, CAS 627833-17-4
N-Allyl-4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazol-5-amine
CAS 627833-17-4C16H14N2O3S2
N-(3-Methoxypropyl)-4-[(4-methylphenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-amine chemical structure, C18H20N2O4S2, CAS 627833-63-0
N-(3-Methoxypropyl)-4-[(4-methylphenyl)sulfonyl]-2-(2-thienyl)-1,3-oxazol-5-amine
CAS 627833-63-0C18H20N2O4S2
N-(2-Methoxyethyl)-4-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)-1,3-oxazol-5-amine chemical structure, C17H18N2O4S2, CAS 627833-72-1
N-(2-Methoxyethyl)-4-(4-methylbenzenesulfonyl)-2-(thiophen-2-yl)-1,3-oxazol-5-amine
CAS 627833-72-1C17H18N2O4S2
5-(sec-Butylthio)-4-((4-chlorophenyl)sulfonyl)-2-(thiophen-2-yl)oxazole chemical structure, C17H16ClNO3S3, CAS 850928-14-2
5-(sec-Butylthio)-4-((4-chlorophenyl)sulfonyl)-2-(thiophen-2-yl)oxazole
CAS 850928-14-2C17H16ClNO3S3