Murcko scaffold
6-Azaspiro[3.4]octan-7-one scaffold
33 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 33
- With full pages
- 7
Scaffold SMILES
O=C1CC2(CCC2)CN1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 33 of 33 chemicals
![7-Oxo-6-azaspiro[3.4]octane-8-carboxylic acid chemical structure, C8H11NO3, CAS 129321-68-2](/s/XPQFCSUUVIBGFB-UHFFFAOYSA-N.svg)
7-Oxo-6-azaspiro[3.4]octane-8-carboxylic acid
CAS 129321-68-2C8H11NO3
![6-Azaspiro[3.4]octan-7-one chemical structure, C7H11NO, CAS 1465480-75-4](/s/HVBBARAIMIAVOW-UHFFFAOYSA-N.svg)
6-Azaspiro[3.4]octan-7-one
CAS 1465480-75-4C7H11NO
![5-Methyl-6-azaspiro[3.4]octan-7-one chemical structure, C8H13NO, CAS 1536763-23-1](/s/TWSAKLVRXOJXBQ-UHFFFAOYSA-N.svg)
5-Methyl-6-azaspiro[3.4]octan-7-one
CAS 1536763-23-1C8H13NO
![7-Oxo-6-azaspiro[3.4]octane-5-carboxylic acid chemical structure, C8H11NO3, CAS 1523055-23-3](/s/RHKYBAXFOZZSGE-UHFFFAOYSA-N.svg)
7-Oxo-6-azaspiro[3.4]octane-5-carboxylic acid
CAS 1523055-23-3C8H11NO3
![Ethyl 7-oxo-6-azaspiro[3.4]octane-5-carboxylate chemical structure, C10H15NO3, CAS 1600314-24-6](/s/APGAHAKIEUOJRS-UHFFFAOYSA-N.svg)
Ethyl 7-oxo-6-azaspiro[3.4]octane-5-carboxylate
CAS 1600314-24-6C10H15NO3
![2-Methoxy-6-azaspiro[3.4]octan-7-one chemical structure, C8H13NO2, CAS 1690468-14-4](/s/URDBPCIZOONVCA-UHFFFAOYSA-N.svg)
2-Methoxy-6-azaspiro[3.4]octan-7-one
CAS 1690468-14-4C8H13NO2
![8-Methyl-6-azaspiro[3.4]octan-7-one chemical structure, C8H13NO, CAS 1935501-71-5](/s/YWQOMJJSLKGUPF-UHFFFAOYSA-N.svg)
8-Methyl-6-azaspiro[3.4]octan-7-one
CAS 1935501-71-5C8H13NO
![2,2-Dimethyl-6-azaspiro[3.4]octan-7-one chemical structure, C9H15NO, CAS 1936501-60-8](/s/FMPOAQRJGDDWBQ-UHFFFAOYSA-N.svg)
2,2-Dimethyl-6-azaspiro[3.4]octan-7-one
CAS 1936501-60-8C9H15NO
![2-Hydroxy-6-azaspiro[3.4]octan-7-one chemical structure, C7H11NO2, CAS 2169556-70-9](/s/CCHMPVXRMIHTHP-UHFFFAOYSA-N.svg)
2-Hydroxy-6-azaspiro[3.4]octan-7-one
CAS 2169556-70-9C7H11NO2
![2-Amino-6-azaspiro[3.4]octan-7-one hydrochloride chemical structure, C7H13ClN2O, CAS 2172063-36-2](/s/PBJVRKMVTJKEIT-UHFFFAOYSA-N.svg)
2-Amino-6-azaspiro[3.4]octan-7-one hydrochloride
CAS 2172063-36-2C7H13ClN2O
![2-Amino-6-azaspiro[3.4]octan-7-one chemical structure, C7H12N2O, CAS 2169073-38-3](/s/FFUAHMGHJOMGLT-UHFFFAOYSA-N.svg)
2-Amino-6-azaspiro[3.4]octan-7-one
CAS 2169073-38-3C7H12N2O
![8-Ethyl-6-azaspiro[3.4]octan-7-one chemical structure, C9H15NO, CAS 2324697-41-6](/s/SWGDVIUDXZGDAN-UHFFFAOYSA-N.svg)
8-Ethyl-6-azaspiro[3.4]octan-7-one
CAS 2324697-41-6C9H15NO
![8-(2-Methylpropyl)-6-azaspiro[3.4]octan-7-one chemical structure, C11H19NO, CAS 2329221-29-4](/s/ZSXOWYJHGAKERN-UHFFFAOYSA-N.svg)
8-(2-Methylpropyl)-6-azaspiro[3.4]octan-7-one
CAS 2329221-29-4C11H19NO
![8-(2-Methoxyethyl)-6-azaspiro[3.4]octan-7-one chemical structure, C10H17NO2, CAS 2329046-84-4](/s/SBBRPEGMROXZBT-UHFFFAOYSA-N.svg)
8-(2-Methoxyethyl)-6-azaspiro[3.4]octan-7-one
CAS 2329046-84-4C10H17NO2
![8-(2,2,2-Trifluoroethyl)-6-azaspiro[3.4]octan-7-one chemical structure, C9H12F3NO, CAS 2324697-43-8](/s/SCBMIQZBDRKSLW-UHFFFAOYSA-N.svg)
8-(2,2,2-Trifluoroethyl)-6-azaspiro[3.4]octan-7-one
CAS 2324697-43-8C9H12F3NO
![8-Amino-6-azaspiro[3.4]octan-7-one hydrochloride chemical structure, C7H13ClN2O, CAS 2319063-68-6](/s/COUZXQUJBZJCMD-UHFFFAOYSA-N.svg)
8-Amino-6-azaspiro[3.4]octan-7-one hydrochloride
CAS 2319063-68-6C7H13ClN2O
![8-Amino-6-azaspiro[3.4]octan-7-one chemical structure, C7H12N2O, CAS 129321-75-1](/s/XSYJJOOANBMISY-UHFFFAOYSA-N.svg)
8-Amino-6-azaspiro[3.4]octan-7-one
CAS 129321-75-1C7H12N2O
![Methyl 7-oxo-6-azaspiro[3.4]octane-2-carboxylate chemical structure, C9H13NO3, CAS 2167976-45-4](/s/HXIWKDZOPHCLSU-UHFFFAOYSA-N.svg)
Methyl 7-oxo-6-azaspiro[3.4]octane-2-carboxylate
CAS 2167976-45-4C9H13NO3
![5-(Iodomethyl)-6-azaspiro[3.4]octan-7-one chemical structure, C8H12INO, CAS 2168445-09-6](/s/SYRUCNLRUFLWNE-UHFFFAOYSA-N.svg)
5-(Iodomethyl)-6-azaspiro[3.4]octan-7-one
CAS 2168445-09-6C8H12INO
![tert-Butyl N-{7-oxo-6-azaspiro[3.4]octan-2-yl}carbamate chemical structure, C12H20N2O3, CAS 2168418-55-9](/s/RRFWAPYXANMBJP-UHFFFAOYSA-N.svg)
tert-Butyl N-{7-oxo-6-azaspiro[3.4]octan-2-yl}carbamate
CAS 2168418-55-9C12H20N2O3
![2-(Hydroxymethyl)-6-azaspiro[3.4]octan-7-one chemical structure, C8H13NO2, CAS 2377033-05-9](/s/WDOSMTYTRCZDKM-UHFFFAOYSA-N.svg)
2-(Hydroxymethyl)-6-azaspiro[3.4]octan-7-one
CAS 2377033-05-9C8H13NO2
![(2E)-4-(Dimethylamino)-N-{7-oxo-6-azaspiro[3.4]octan-2-yl}but-2-enamide chemical structure, C13H21N3O2, CAS 2411323-43-6](/s/QIIRHTGRPQOVDB-ONEGZZNKSA-N.svg)
(2E)-4-(Dimethylamino)-N-{7-oxo-6-azaspiro[3.4]octan-2-yl}but-2-enamide
CAS 2411323-43-6C13H21N3O2
![N-(7-Oxo-6-azaspiro[3.4]octan-2-yl)but-2-ynamide chemical structure, C11H14N2O2, CAS 2411200-75-2](/s/VMRMTPWOSVJSNB-UHFFFAOYSA-N.svg)
N-(7-Oxo-6-azaspiro[3.4]octan-2-yl)but-2-ynamide
CAS 2411200-75-2C11H14N2O2
![2-Chloro-N-(7-oxo-6-azaspiro[3.4]octan-2-yl)acetamide chemical structure, C9H13ClN2O2, CAS 2411284-27-8](/s/FNNUPBFLCUYXBY-UHFFFAOYSA-N.svg)
2-Chloro-N-(7-oxo-6-azaspiro[3.4]octan-2-yl)acetamide
CAS 2411284-27-8C9H13ClN2O2
- 1-Hydroxy-6-aza-spiro[3.4]octan-7-one2408429-56-9C7H11NO2
- (R)-8-Amino-6-azaspiro[3.4]octan-7-one2610054-16-3C7H12N2O
- (8R)-8-Amino-5-ethyl-6-azaspiro[3.4]octan-7-one2610054-18-5C9H16N2O
- 2-Amino-1,1-dimethyl-6-azaspiro[3.4]octan-7-one2172053-19-7C9H16N2O
- 5-(Aminomethyl)-6-azaspiro[3.4]octan-7-one hydrochloride2174002-03-8C8H15ClN2O
- 5-(Aminomethyl)-6-azaspiro[3.4]octan-7-one2167832-31-5C8H14N2O
- 2,2-Difluoro-6-azaspiro[3.4]octan-7-one2296273-15-7C7H9F2NO
- 7-Oxo-6-azaspiro[3.4]octane-2-carboxylic acid2168296-16-8C8H11NO3
- 8-Hydroxy-6-azaspiro[3.4]octan-7-one2387288-52-8C7H11NO2
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals