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Murcko scaffold

Spiro[indoline-3,4'-piperidine] scaffold

121 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
121
With full pages
7
Scaffold SMILES

c1ccc2c(c1)NCC21CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[indoline-3,4'-piperidine] page
Murcko scaffold c1ccc2c(c1)NCC21CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 121 of 121 chemicals

5-Methyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C18H26N2O, CAS 1427504-43-5
5-Methyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427504-43-5C18H26N2O
4,6-Dimethoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O3, CAS 1427502-96-2
4,6-Dimethoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427502-96-2C19H28N2O3
4,6-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O, CAS 1427502-79-1
4,6-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427502-79-1C19H28N2O
4-Fluoro-7-methoxy-3-spiral indoline-N'-boc-4-piperidine chemical structure, C18H25FN2O3, CAS 1427504-44-6
4-Fluoro-7-methoxy-3-spiral indoline-N'-boc-4-piperidine
CAS 1427504-44-6C18H25FN2O3
5,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O, CAS 1427503-17-0
5,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427503-17-0C19H28N2O
5,6-Dimethoxy-3-spiral indoline-N'-boc-4-piperidine chemical structure, C19H28N2O4, CAS 1427502-64-4
5,6-Dimethoxy-3-spiral indoline-N'-boc-4-piperidine
CAS 1427502-64-4C19H28N2O4
7-Ethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O, CAS 1427502-54-2
7-Ethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427502-54-2C19H28N2O
5-Methoxy-7-methyl-3-spiral indoline-N-BOC-4-piperidine chemical structure, C19H28N2O3, CAS 1427504-26-4
5-Methoxy-7-methyl-3-spiral indoline-N-BOC-4-piperidine
CAS 1427504-26-4C19H28N2O3
4,6-Dimethoxy-3-spiral indoline-N'-boc-4-piperidine chemical structure, C19H28N2O4, CAS 1427502-36-0
4,6-Dimethoxy-3-spiral indoline-N'-boc-4-piperidine
CAS 1427502-36-0C19H28N2O4
4,6-Dimethyl-3-spiral indoline-N'-boc-4-piperidine chemical structure, C19H28N2O2, CAS 1427504-66-2
4,6-Dimethyl-3-spiral indoline-N'-boc-4-piperidine
CAS 1427504-66-2C19H28N2O2
6,7-Dimethyl-3-spiral indoline-N'-boc-4-piperidine chemical structure, C19H28N2O2, CAS 1427503-35-2
6,7-Dimethyl-3-spiral indoline-N'-boc-4-piperidine
CAS 1427503-35-2C19H28N2O2
4,7-Dimethyl-3-spiral indoline-N'-boc-4-piperidine chemical structure, C19H28N2O2, CAS 1427504-67-3
4,7-Dimethyl-3-spiral indoline-N'-boc-4-piperidine
CAS 1427504-67-3C19H28N2O2
4,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O, CAS 1427503-42-1
4,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427503-42-1C19H28N2O
6,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O, CAS 1427503-77-2
6,7-Dimethyl-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427503-77-2C19H28N2O
5-Methoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C18H26N2O2, CAS 1427502-65-5
5-Methoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427502-65-5C18H26N2O2
5,6-Dimethoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine chemical structure, C19H28N2O3, CAS 1427502-43-9
5,6-Dimethoxy-3-spiral indoline-4'-(N'-2,2dimethylpropanoyl)-piperidine
CAS 1427502-43-9C19H28N2O3
tert-Butyl 4-methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate chemical structure, C18H26N2O3, CAS 2251053-64-0
tert-Butyl 4-methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate
CAS 2251053-64-0C18H26N2O3
5-Fluoro-1'-methylspiro[indoline-3,4'-piperidine] dihydrochloride chemical structure, C13H19Cl2FN2, CAS 858351-48-1
5-Fluoro-1'-methylspiro[indoline-3,4'-piperidine] dihydrochloride
CAS 858351-48-1C13H19Cl2FN2
1'-tert-Butyl 5-methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1',5-dicarboxylate chemical structure, C19H26N2O4, CAS 2920408-00-8
1'-tert-Butyl 5-methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1',5-dicarboxylate
CAS 2920408-00-8C19H26N2O4
5-Chloro-1-methyl-1,2-dihydrospiro[indole-3,4'-piperidine]dihydrochloride chemical structure, C13H19Cl3N2, CAS 2770368-73-3
5-Chloro-1-methyl-1,2-dihydrospiro[indole-3,4'-piperidine]dihydrochloride
CAS 2770368-73-3C13H19Cl3N2
Methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-6-carboxylate chemical structure, C14H18N2O2, CAS 2703773-46-8
Methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-6-carboxylate
CAS 2703773-46-8C14H18N2O2
Methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-6-carboxylate dihydrochloride chemical structure, C14H20Cl2N2O2, CAS 2703781-54-6
Methyl 1,2-dihydrospiro[indole-3,4'-piperidine]-6-carboxylate dihydrochloride
CAS 2703781-54-6C14H20Cl2N2O2
7-Bromospiro[1,2-dihydroindole-3,4'-piperidine] chemical structure, C12H15BrN2, CAS 1824069-78-4
7-Bromospiro[1,2-dihydroindole-3,4'-piperidine]
CAS 1824069-78-4C12H15BrN2
Spiro[3H-indole-3,4'-piperidine], 5-chloro-1,2-dihydro-, hydrochloride (1:2) chemical structure, C12H16Cl2N2, CAS 2216747-16-7
Spiro[3H-indole-3,4'-piperidine], 5-chloro-1,2-dihydro-, hydrochloride (1:2)
CAS 2216747-16-7C12H16Cl2N2