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Murcko scaffold

Ring system with 3 rings and 19 atoms

58 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 58
With full pages: 4

Scaffold SMILES

O=C1N=C(N2CCNCC2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1N=C(N2CCNCC2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

(5Z)-5-[(4-Methylphenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one chemical structure, C16H19N3OS, CAS 1347744-90-4

(5Z)-5-[(4-Methylphenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one

CAS 1347744-90-4C₁₆H₁₉N₃OS

(5Z)-2-[4-(2-Hydroxyethyl)piperazin-1-yl]-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one chemical structure, C16H19N3O3S, CAS 377060-28-1

(5Z)-2-[4-(2-Hydroxyethyl)piperazin-1-yl]-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one

CAS 377060-28-1C₁₆H₁₉N₃O₃S

(E)-5-(2-Isopropoxybenzylidene)-2-(4-methylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C18H23N3O2S, CAS 844659-43-4

(E)-5-(2-Isopropoxybenzylidene)-2-(4-methylpiperazin-1-yl)thiazol-4(5H)-one

CAS 844659-43-4C₁₈H₂₃N₃O₂S

(5Z)-2-(4-Methylpiperazin-1-yl)-5-[2-(propan-2-yloxy)benzylidene]-1,3-thiazol-4(5H)-one chemical structure, C18H23N3O2S

(5Z)-2-(4-Methylpiperazin-1-yl)-5-[2-(propan-2-yloxy)benzylidene]-1,3-thiazol-4(5H)-one

C₁₈H₂₃N₃O₂S

2-(4-Acetyl-1-piperazinyl)-5-(2-isopropoxybenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C19H23N3O3S, CAS 384358-88-7

2-(4-Acetyl-1-piperazinyl)-5-(2-isopropoxybenzylidene)-1,3-thiazol-4(5H)-one

CAS 384358-88-7C₁₉H₂₃N₃O₃S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-(diethylamino)benzylidene)thiazol-4(5H)-one chemical structure, C20H26N4O2S, CAS 333424-05-8

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-(diethylamino)benzylidene)thiazol-4(5H)-one

CAS 333424-05-8C₂₀H₂₆N₄O₂S

(5Z)-5-[(4-Chlorophenyl)methylidene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4-one chemical structure, C16H18ClN3O2S, CAS 378205-83-5

(5Z)-5-[(4-Chlorophenyl)methylidene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4-one

CAS 378205-83-5C₁₆H₁₈ClN₃O₂S

(5Z)-5-[(4-Bromophenyl)methylidene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4-one chemical structure, C16H18BrN3O2S, CAS 378200-38-5

(5Z)-5-[(4-Bromophenyl)methylidene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4-one

CAS 378200-38-5C₁₆H₁₈BrN₃O₂S

5-[(3,4-Dimethoxyphenyl)methylene]-2-(4-ethyl-1-piperazinyl)-4(5H)-thiazolone chemical structure, C18H23N3O3S, CAS 378203-87-3

5-[(3,4-Dimethoxyphenyl)methylene]-2-(4-ethyl-1-piperazinyl)-4(5H)-thiazolone

CAS 378203-87-3C₁₈H₂₃N₃O₃S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-ethoxybenzylidene)thiazol-4(5H)-one chemical structure, C18H21N3O3S, CAS 384795-33-9

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-ethoxybenzylidene)thiazol-4(5H)-one

CAS 384795-33-9C₁₈H₂₁N₃O₃S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-isopropoxybenzylidene)thiazol-4(5H)-one chemical structure, C19H23N3O3S, CAS 384802-88-4

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-isopropoxybenzylidene)thiazol-4(5H)-one

CAS 384802-88-4C₁₉H₂₃N₃O₃S

(5Z)-5-[(4-Chlorophenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one chemical structure, C15H16ClN3OS, CAS 1347744-91-5

(5Z)-5-[(4-Chlorophenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one

CAS 1347744-91-5C₁₅H₁₆ClN₃OS

(E)-2-(4-Acetylpiperazin-1-yl)-5-benzylidenethiazol-4(5H)-one chemical structure, C16H17N3O2S, CAS 304889-76-7

(E)-2-(4-Acetylpiperazin-1-yl)-5-benzylidenethiazol-4(5H)-one

CAS 304889-76-7C₁₆H₁₇N₃O₂S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-hydroxybenzylidene)thiazol-4(5H)-one chemical structure, C16H17N3O3S, CAS 304889-79-0

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-hydroxybenzylidene)thiazol-4(5H)-one

CAS 304889-79-0C₁₆H₁₇N₃O₃S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-chlorobenzylidene)thiazol-4(5H)-one chemical structure, C16H16ClN3O2S, CAS 304889-81-4

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-chlorobenzylidene)thiazol-4(5H)-one

CAS 304889-81-4C₁₆H₁₆ClN₃O₂S

(5Z)-2-(4-Acetylpiperazin-1-yl)-5-[(3-nitrophenyl)methylidene]-1,3-thiazol-4-one chemical structure, C16H16N4O4S

(5Z)-2-(4-Acetylpiperazin-1-yl)-5-[(3-nitrophenyl)methylidene]-1,3-thiazol-4-one

C₁₆H₁₆N₄O₄S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylidene)thiazol-4(5H)-one chemical structure, C16H16N4O4S, CAS 383895-93-0

(E)-2-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylidene)thiazol-4(5H)-one

CAS 383895-93-0C₁₆H₁₆N₄O₄S

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-hydroxy-3-nitrobenzylidene)thiazol-4(5H)-one chemical structure, C16H16N4O5S, CAS 371139-05-8

(E)-2-(4-Acetylpiperazin-1-yl)-5-(4-hydroxy-3-nitrobenzylidene)thiazol-4(5H)-one

CAS 371139-05-8C₁₆H₁₆N₄O₅S

5-{4-Nitrobenzylidene}-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4(5H)-one chemical structure, C15H16N4O3S, CAS 300560-28-5

5-{4-Nitrobenzylidene}-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4(5H)-one

CAS 300560-28-5C₁₅H₁₆N₄O₃S

(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one chemical structure, C15H17N3O2S, CAS 300560-30-9

(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-one

CAS 300560-30-9C₁₅H₁₇N₃O₂S

Methyl 4-[(2-(4-methyl-1-piperazinyl)-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl]benzoate chemical structure, C17H19N3O3S, CAS 307342-96-7

Methyl 4-[(2-(4-methyl-1-piperazinyl)-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl]benzoate

CAS 307342-96-7C₁₇H₁₉N₃O₃S

(E)-3-(4-(5-(4-(Dimethylamino)benzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperazin-1-yl)propanenitrile chemical structure, C19H23N5OS, CAS 375829-33-7

(E)-3-(4-(5-(4-(Dimethylamino)benzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperazin-1-yl)propanenitrile

CAS 375829-33-7C₁₉H₂₃N₅OS

(E)-2-(4-Methylpiperazin-1-yl)-5-(2-propoxybenzylidene)thiazol-4(5H)-one chemical structure, C18H23N3O2S, CAS 573935-87-2

(E)-2-(4-Methylpiperazin-1-yl)-5-(2-propoxybenzylidene)thiazol-4(5H)-one

CAS 573935-87-2C₁₈H₂₃N₃O₂S

5-[4-(Dimethylamino)benzylidene]-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4(5H)-one chemical structure, C17H22N4OS, CAS 372507-09-0

5-[4-(Dimethylamino)benzylidene]-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4(5H)-one

CAS 372507-09-0C₁₇H₂₂N₄OS