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Murcko scaffold

Ring system with 3 rings and 19 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
19
With full pages
5
Scaffold SMILES

c1ccc(Sc2ccc(-c3ccccc3)cn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2ccc(-c3ccccc3)cn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

6-Methyl-5-phenyl-2-(phenylthio)-3-pyridinecarbonitrile chemical structure, C19H14N2S, CAS 338423-74-8
6-Methyl-5-phenyl-2-(phenylthio)-3-pyridinecarbonitrile
CAS 338423-74-8C19H14N2S
5-(4-Chlorophenyl)-2-(phenylsulfanyl)nicotinonitrile chemical structure, C18H11ClN2S, CAS 338955-03-6
5-(4-Chlorophenyl)-2-(phenylsulfanyl)nicotinonitrile
CAS 338955-03-6C18H11ClN2S
5-(4-Chlorophenyl)-2-[(4-fluorophenyl)sulfanyl]nicotinonitrile chemical structure, C18H10ClFN2S, CAS 338955-19-4
5-(4-Chlorophenyl)-2-[(4-fluorophenyl)sulfanyl]nicotinonitrile
CAS 338955-19-4C18H10ClFN2S
5-[3-(Trifluoromethyl)phenyl]-2-{[3-(trifluoromethyl)phenyl]sulfanyl}nicotinonitrile chemical structure, C20H10F6N2S, CAS 338964-89-9
5-[3-(Trifluoromethyl)phenyl]-2-{[3-(trifluoromethyl)phenyl]sulfanyl}nicotinonitrile
CAS 338964-89-9C20H10F6N2S
5-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]nicotinonitrile chemical structure, C18H9Cl3N2S, CAS 338955-21-8
5-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]nicotinonitrile
CAS 338955-21-8C18H9Cl3N2S
2-[(4-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10ClF3N2S, CAS 338964-75-3
2-[(4-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-75-3C19H10ClF3N2S
2-[(3-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10ClF3N2S, CAS 338964-73-1
2-[(3-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-73-1C19H10ClF3N2S
2-[(4-Chlorophenyl)sulfanyl]-5-phenylnicotinonitrile chemical structure, C18H11ClN2S, CAS 866048-91-1
2-[(4-Chlorophenyl)sulfanyl]-5-phenylnicotinonitrile
CAS 866048-91-1C18H11ClN2S
2-[(2,6-Dichlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H9Cl2F3N2S, CAS 338964-85-5
2-[(2,6-Dichlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-85-5C19H9Cl2F3N2S
5-Phenyl-2-(phenylsulfanyl)nicotinonitrile chemical structure, C18H12N2S, CAS 338795-41-8
5-Phenyl-2-(phenylsulfanyl)nicotinonitrile
CAS 338795-41-8C18H12N2S
2-[(2-Methoxyphenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C20H13F3N2OS, CAS 338964-79-7
2-[(2-Methoxyphenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-79-7C20H13F3N2OS
2-(Phenylsulfanyl)-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H11F3N2S, CAS 338964-69-5
2-(Phenylsulfanyl)-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-69-5C19H11F3N2S
2-[(2-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10ClF3N2S, CAS 338964-71-9
2-[(2-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-71-9C19H10ClF3N2S
2-[(3,4-Dichlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H9Cl2F3N2S, CAS 338964-87-7
2-[(3,4-Dichlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-87-7C19H9Cl2F3N2S
2-[(4-Methoxyphenyl)sulfanyl]-5-phenylnicotinonitrile chemical structure, C19H14N2OS, CAS 338795-42-9
2-[(4-Methoxyphenyl)sulfanyl]-5-phenylnicotinonitrile
CAS 338795-42-9C19H14N2OS
5-(4-Chlorophenyl)-2-[(2-chlorophenyl)sulfanyl]nicotinonitrile chemical structure, C18H10Cl2N2S, CAS 338955-04-7
5-(4-Chlorophenyl)-2-[(2-chlorophenyl)sulfanyl]nicotinonitrile
CAS 338955-04-7C18H10Cl2N2S
5-(4-Chlorophenyl)-2-[(4-methoxyphenyl)sulfanyl]nicotinonitrile chemical structure, C19H13ClN2OS, CAS 338954-94-2
5-(4-Chlorophenyl)-2-[(4-methoxyphenyl)sulfanyl]nicotinonitrile
CAS 338954-94-2C19H13ClN2OS
5-(4-Chlorophenyl)-2-[(3-chlorophenyl)sulfanyl]nicotinonitrile chemical structure, C18H10Cl2N2S, CAS 338955-11-6
5-(4-Chlorophenyl)-2-[(3-chlorophenyl)sulfanyl]nicotinonitrile
CAS 338955-11-6C18H10Cl2N2S
2-[(4-Fluorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10F4N2S, CAS 338964-77-5
2-[(4-Fluorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 338964-77-5C19H10F4N2S