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Murcko scaffold

N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide scaffold

577 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
577
With full pages
4
Scaffold SMILES

O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide page
Murcko scaffold O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 145 to 192 of 577 chemicals

N-(5-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide chemical structure, C20H17F3N4O2S2, CAS 392296-45-6
N-(5-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide
CAS 392296-45-6C20H17F3N4O2S2
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methylbenzamide chemical structure, C19H14ClF3N4O2S2, CAS 392299-01-3
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methylbenzamide
CAS 392299-01-3C19H14ClF3N4O2S2
2,4-Dichloro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H14Cl2N4O2S2, CAS 392291-72-4
2,4-Dichloro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-72-4C18H14Cl2N4O2S2
N-[5-[2-(2-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methylbenzamide chemical structure, C18H15FN4O2S2, CAS 392298-46-3
N-[5-[2-(2-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-methylbenzamide
CAS 392298-46-3C18H15FN4O2S2
N-[5-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2,3-dimethoxybenzamide chemical structure, C19H17BrN4O4S2, CAS 391869-38-8
N-[5-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2,3-dimethoxybenzamide
CAS 391869-38-8C19H17BrN4O4S2
3-Methyl-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H16N4O2S2, CAS 392290-80-1
3-Methyl-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392290-80-1C18H16N4O2S2
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,5-dimethylbenzamide chemical structure, C20H16ClF3N4O2S2, CAS 392299-20-6
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,5-dimethylbenzamide
CAS 392299-20-6C20H16ClF3N4O2S2
3,4,5-Trimethoxy-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C21H22N4O5S2, CAS 392291-77-9
3,4,5-Trimethoxy-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-77-9C21H22N4O5S2
N-(5-((2-Oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H16N4O2S2, CAS 392292-05-6
N-(5-((2-Oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392292-05-6C18H16N4O2S2
2-Methyl-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O2S2, CAS 392292-06-7
2-Methyl-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392292-06-7C19H18N4O2S2
3-Methyl-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O2S2, CAS 392292-07-8
3-Methyl-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392292-07-8C19H18N4O2S2
N-[5-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3-methylbenzamide chemical structure, C20H20N4O2S2, CAS 392295-64-6
N-[5-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3-methylbenzamide
CAS 392295-64-6C20H20N4O2S2
4-Ethoxy-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H17FN4O3S2, CAS 392297-74-4
4-Ethoxy-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392297-74-4C19H17FN4O3S2
4-Butoxy-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C21H21FN4O3S2, CAS 392297-73-3
4-Butoxy-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392297-73-3C21H21FN4O3S2
Ethyl 4-(2-((5-(3,4,5-triethoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate chemical structure, C26H30N4O7S2, CAS 392293-38-8
Ethyl 4-(2-((5-(3,4,5-triethoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate
CAS 392293-38-8C26H30N4O7S2
4-Ethoxy-N-[5-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C20H17F3N4O3S2, CAS 392297-13-1
4-Ethoxy-N-[5-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392297-13-1C20H17F3N4O3S2
2,4-Dichloro-N-[5-[2-(3,5-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C19H16Cl2N4O2S2, CAS 392296-59-2
2,4-Dichloro-N-[5-[2-(3,5-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392296-59-2C19H16Cl2N4O2S2
2-Iodo-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H15IN4O2S2, CAS 389072-62-2
2-Iodo-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 389072-62-2C18H15IN4O2S2
5-Bromo-2-chloro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C17H11BrClFN4O2S2, CAS 391874-48-9
5-Bromo-2-chloro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 391874-48-9C17H11BrClFN4O2S2
2-Methoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H15F3N4O3S2, CAS 392297-02-8
2-Methoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392297-02-8C19H15F3N4O3S2
2,4-Dimethoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C20H17F3N4O4S2, CAS 392297-21-1
2,4-Dimethoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392297-21-1C20H17F3N4O4S2
Ethyl 4-(2-((5-(5-chloro-2-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate chemical structure, C21H19ClN4O5S2, CAS 391874-52-5
Ethyl 4-(2-((5-(5-chloro-2-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate
CAS 391874-52-5C21H19ClN4O5S2
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide chemical structure, C18H12F4N4O2S2, CAS 392297-70-0
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide
CAS 392297-70-0C18H12F4N4O2S2
3,5-Dichloro-N-(5-((2-((2,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H16Cl2N4O2S2, CAS 392295-23-7
3,5-Dichloro-N-(5-((2-((2,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392295-23-7C19H16Cl2N4O2S2