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Murcko scaffold

N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide scaffold

577 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
577
With full pages
4
Scaffold SMILES

O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide page
Murcko scaffold O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 193 to 240 of 577 chemicals

N-[5-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-5-chloro-2-methoxybenzamide chemical structure, C18H14BrClN4O3S2, CAS 389073-10-3
N-[5-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-5-chloro-2-methoxybenzamide
CAS 389073-10-3C18H14BrClN4O3S2
3,5-Dichloro-N-[5-[2-(4-fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C17H11Cl2FN4O2S2, CAS 392297-77-7
3,5-Dichloro-N-[5-[2-(4-fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392297-77-7C17H11Cl2FN4O2S2
2,5-Dichloro-N-[5-[2-(2,5-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C19H16Cl2N4O2S2, CAS 392295-25-9
2,5-Dichloro-N-[5-[2-(2,5-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392295-25-9C19H16Cl2N4O2S2
5-Chloro-2-methoxy-N-[5-[2-(3-methylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C19H17ClN4O3S2, CAS 391869-05-9
5-Chloro-2-methoxy-N-[5-[2-(3-methylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 391869-05-9C19H17ClN4O3S2
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,4,5-trimethoxybenzamide chemical structure, C21H18ClF3N4O5S2, CAS 392299-27-3
N-[5-[2-[2-Chloro-5-(trifluoromethyl)anilino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,4,5-trimethoxybenzamide
CAS 392299-27-3C21H18ClF3N4O5S2
Ethyl 4-[[2-[[5-[(4-butoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C24H26N4O5S2, CAS 392293-29-7
Ethyl 4-[[2-[[5-[(4-butoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 392293-29-7C24H26N4O5S2
N-(5-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-fluorobenzamide chemical structure, C19H17FN4O2S2, CAS 392296-43-4
N-(5-((2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-fluorobenzamide
CAS 392296-43-4C19H17FN4O2S2
4-Ethoxy-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C20H20N4O3S2, CAS 392291-64-4
4-Ethoxy-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-64-4C20H20N4O3S2
3-Methoxy-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H16N4O3S2, CAS 392290-89-0
3-Methoxy-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392290-89-0C18H16N4O3S2
N-(5-((2-((2-Chloro-5-(trifluoromethyl)phenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-methoxybenzamide chemical structure, C19H14ClF3N4O3S2, CAS 392299-07-9
N-(5-((2-((2-Chloro-5-(trifluoromethyl)phenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-methoxybenzamide
CAS 392299-07-9C19H14ClF3N4O3S2
Ethyl 4-(2-((5-(2,4-dichlorobenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate chemical structure, C20H16Cl2N4O4S2, CAS 392293-33-3
Ethyl 4-(2-((5-(2,4-dichlorobenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate
CAS 392293-33-3C20H16Cl2N4O4S2
N-(5-((2-((2,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide chemical structure, C20H17F3N4O2S2, CAS 392295-17-9
N-(5-((2-((2,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)benzamide
CAS 392295-17-9C20H17F3N4O2S2
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-methoxybenzamide chemical structure, C20H20N4O3S2, CAS 392294-42-7
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-methoxybenzamide
CAS 392294-42-7C20H20N4O3S2
4-(tert-Butyl)-N-(5-((2-((3,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C23H26N4O2S2, CAS 392296-46-7
4-(tert-Butyl)-N-(5-((2-((3,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392296-46-7C23H26N4O2S2
N-(5-((2-((2,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbenzamide chemical structure, C20H20N4O2S2, CAS 392295-00-0
N-(5-((2-((2,5-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbenzamide
CAS 392295-00-0C20H20N4O2S2
N-(5-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3,5-dimethoxybenzamide chemical structure, C19H17FN4O4S2, CAS 392298-72-5
N-(5-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3,5-dimethoxybenzamide
CAS 392298-72-5C19H17FN4O4S2
2,6-Dimethoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C20H17F3N4O4S2, CAS 391869-72-0
2,6-Dimethoxy-N-(5-((2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 391869-72-0C20H17F3N4O4S2
2-Methoxy-N-(5-((2-((4-methoxyphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O4S2, CAS 392293-73-1
2-Methoxy-N-(5-((2-((4-methoxyphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392293-73-1C19H18N4O4S2
N-(5-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide chemical structure, C18H12F4N4O2S2, CAS 391869-31-1
N-(5-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide
CAS 391869-31-1C18H12F4N4O2S2
3-Fluoro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H15FN4O2S2, CAS 392291-57-5
3-Fluoro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-57-5C18H15FN4O2S2
4-Bromo-N-[5-[2-(2,3-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C19H17BrN4O2S2, CAS 392294-39-2
4-Bromo-N-[5-[2-(2,3-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392294-39-2C19H17BrN4O2S2
Ethyl 4-(2-((5-(4,5-dimethoxy-2-nitrobenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate chemical structure, C22H21N5O8S2, CAS 389073-15-8
Ethyl 4-(2-((5-(4,5-dimethoxy-2-nitrobenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate
CAS 389073-15-8C22H21N5O8S2
2-Chloro-N-(5-((2-((2,4-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H17ClN4O2S2, CAS 392295-68-0
2-Chloro-N-(5-((2-((2,4-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392295-68-0C19H17ClN4O2S2
4-Butoxy-N-(5-((2-((2,3-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C23H26N4O3S2, CAS 392294-54-1
4-Butoxy-N-(5-((2-((2,3-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392294-54-1C23H26N4O3S2