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Murcko scaffold

N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide scaffold

577 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
577
With full pages
4
Scaffold SMILES

O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(5-((2-Oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide page
Murcko scaffold O=C(CSc1nnc(NC(=O)c2ccccc2)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 289 to 336 of 577 chemicals

Ethyl 4-[[2-[[5-[(3-methoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C21H20N4O5S2, CAS 392293-18-4
Ethyl 4-[[2-[[5-[(3-methoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 392293-18-4C21H20N4O5S2
3,4,5-Trimethoxy-N-[5-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C21H19F3N4O5S2, CAS 392297-23-3
3,4,5-Trimethoxy-N-[5-[2-oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392297-23-3C21H19F3N4O5S2
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O2S2, CAS 392294-30-3
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392294-30-3C19H18N4O2S2
Ethyl 4-[[2-[[5-[[4-(dimethylsulfamoyl)benzoyl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C22H23N5O6S3, CAS 389073-64-7
Ethyl 4-[[2-[[5-[[4-(dimethylsulfamoyl)benzoyl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 389073-64-7C22H23N5O6S3
N-[5-[2-(2,3-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methoxybenzamide chemical structure, C20H20N4O3S2, CAS 392294-40-5
N-[5-[2-(2,3-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methoxybenzamide
CAS 392294-40-5C20H20N4O3S2
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3,4,5-trimethoxybenzamide chemical structure, C20H19FN4O5S2, CAS 389073-16-9
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3,4,5-trimethoxybenzamide
CAS 389073-16-9C20H19FN4O5S2
4-Fluoro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C17H12F2N4O2S2, CAS 392297-69-7
4-Fluoro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392297-69-7C17H12F2N4O2S2
3-Bromo-N-[5-[2-(2,4-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C19H17BrN4O2S2, CAS 392295-70-4
3-Bromo-N-[5-[2-(2,4-dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392295-70-4C19H17BrN4O2S2
3-Bromo-N-(5-((2-((2,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H17BrN4O2S2, CAS 392295-06-6
3-Bromo-N-(5-((2-((2,5-dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392295-06-6C19H17BrN4O2S2
Ethyl 4-(2-((5-(3,4,5-trimethoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate chemical structure, C23H24N4O7S2, CAS 392293-37-7
Ethyl 4-(2-((5-(3,4,5-trimethoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)benzoate
CAS 392293-37-7C23H24N4O7S2
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-fluorobenzamide chemical structure, C19H17FN4O2S2, CAS 392294-47-2
N-(5-((2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-fluorobenzamide
CAS 392294-47-2C19H17FN4O2S2
N-[5-[2-(2,5-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,4,5-trimethoxybenzamide chemical structure, C22H24N4O5S2, CAS 392295-30-6
N-[5-[2-(2,5-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,4,5-trimethoxybenzamide
CAS 392295-30-6C22H24N4O5S2
Ethyl 4-[[2-[[5-[(3,5-dichlorobenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C20H16Cl2N4O4S2, CAS 392293-32-2
Ethyl 4-[[2-[[5-[(3,5-dichlorobenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 392293-32-2C20H16Cl2N4O4S2
4-Chloro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C18H15ClN4O2S2, CAS 392291-44-0
4-Chloro-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-44-0C18H15ClN4O2S2
Ethyl 4-[[2-[[5-[(2-bromobenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C20H17BrN4O4S2, CAS 392293-14-0
Ethyl 4-[[2-[[5-[(2-bromobenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 392293-14-0C20H17BrN4O4S2
3-Methyl-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O2S2, CAS 392291-42-8
3-Methyl-N-(5-((2-oxo-2-(p-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392291-42-8C19H18N4O2S2
N-[5-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-fluorobenzamide chemical structure, C19H17FN4O2S2, CAS 392295-80-6
N-[5-[2-(2,4-Dimethylanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-4-fluorobenzamide
CAS 392295-80-6C19H17FN4O2S2
N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methylbenzamide chemical structure, C18H15FN4O2S2, CAS 392297-52-8
N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methylbenzamide
CAS 392297-52-8C18H15FN4O2S2
N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,5-dimethoxybenzamide chemical structure, C19H17FN4O4S2, CAS 392297-82-4
N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-3,5-dimethoxybenzamide
CAS 392297-82-4C19H17FN4O4S2
3-Methoxy-N-(5-((2-((4-methoxyphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C19H18N4O4S2, CAS 392293-74-2
3-Methoxy-N-(5-((2-((4-methoxyphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 392293-74-2C19H18N4O4S2
2-Chloro-6-fluoro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide chemical structure, C17H11ClF2N4O2S2, CAS 391869-85-5
2-Chloro-6-fluoro-N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
CAS 391869-85-5C17H11ClF2N4O2S2
Ethyl 4-[[2-[[5-[(4-methoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate chemical structure, C21H20N4O5S2, CAS 392293-19-5
Ethyl 4-[[2-[[5-[(4-methoxybenzoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
CAS 392293-19-5C21H20N4O5S2
4-tert-Butyl-N-[5-[2-(4-fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C21H21FN4O2S2, CAS 392297-71-1
4-tert-Butyl-N-[5-[2-(4-fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392297-71-1C21H21FN4O2S2
3-Fluoro-N-[5-[2-(4-methoxyanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide chemical structure, C18H15FN4O3S2, CAS 392293-80-0
3-Fluoro-N-[5-[2-(4-methoxyanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
CAS 392293-80-0C18H15FN4O3S2