Murcko scaffold
Ring system with 3 rings and 18 atoms
50 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 18
- Chemicals
- 50
- With full pages
- 5
Scaffold SMILES
c1ccc(Sc2cc(-c3ccccc3)n[nH]2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold c1ccc(Sc2cc(-c3ccccc3)n[nH]2)cc1](/scaffold/NEELEVWEBRBBBE-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 50 chemicals
![Methyl 2-[(4-formyl-1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfanyl]benzenecarboxylate chemical structure, C19H16N2O3S, CAS 321538-23-2](/s/WWACCRLWHFUZSS-UHFFFAOYSA-N.svg)
Methyl 2-[(4-formyl-1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfanyl]benzenecarboxylate
CAS 321538-23-2C19H16N2O3S
1-Methyl-3-phenyl-5-(phenylsulfanyl)-1H-pyrazole-4-carbonitrile
CAS 321998-24-7C17H13N3S
![1-Methyl-3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazole-4-carbonitrile chemical structure, C18H12F3N3S, CAS 321998-25-8](/s/BEPYJVLMEOQVRH-UHFFFAOYSA-N.svg)
1-Methyl-3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazole-4-carbonitrile
CAS 321998-25-8C18H12F3N3S
![5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C17H12ClN3S, CAS 321998-26-9](/s/GEVLNPHAUTYHCZ-UHFFFAOYSA-N.svg)
5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-26-9C17H12ClN3S
![1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C18H15N3S, CAS 321998-34-9](/s/WHFZLUKOOQAAMC-UHFFFAOYSA-N.svg)
1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-34-9C18H15N3S
![1-Methyl-5-[(2-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C18H15N3S, CAS 321998-35-0](/s/QKWGNKVBOSTKAI-UHFFFAOYSA-N.svg)
1-Methyl-5-[(2-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-35-0C18H15N3S
![5-[(3-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C17H12ClN3S, CAS 321998-36-1](/s/HLTYMHSLJJABNT-UHFFFAOYSA-N.svg)
5-[(3-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-36-1C17H12ClN3S
![5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C17H12FN3S, CAS 321998-37-2](/s/PENMXIXPVNSFDM-UHFFFAOYSA-N.svg)
5-[(4-Fluorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-37-2C17H12FN3S
![{1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methyl acetate chemical structure, C20H20N2O2S, CAS 318247-45-9](/s/GJPTVQORQCMNEL-UHFFFAOYSA-N.svg)
{1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methyl acetate
CAS 318247-45-9C20H20N2O2S
![5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C17H13ClN2OS, CAS 318247-50-6](/s/PRDGDACLIUJNAB-UHFFFAOYSA-N.svg)
5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde
CAS 318247-50-6C17H13ClN2OS
![5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C17H13BrN2OS, CAS 318247-52-8](/s/QBGLDFCJVXLSKX-UHFFFAOYSA-N.svg)
5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde
CAS 318247-52-8C17H13BrN2OS
![{5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol chemical structure, C17H15BrN2OS, CAS 318247-56-2](/s/UZPXOUHEPKIFIX-UHFFFAOYSA-N.svg)
{5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol
CAS 318247-56-2C17H15BrN2OS
![{5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl methyl ether chemical structure, C18H17ClN2OS, CAS 318247-66-4](/s/HAOJCFKWDMOKPJ-UHFFFAOYSA-N.svg)
{5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl methyl ether
CAS 318247-66-4C18H17ClN2OS
![(1-Methyl-3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methanol chemical structure, C18H15F3N2OS, CAS 318247-69-7](/s/AWHHXKDKURXYOF-UHFFFAOYSA-N.svg)
(1-Methyl-3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazol-4-yl)methanol
CAS 318247-69-7C18H15F3N2OS
![{5-[(2,6-Dichlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol chemical structure, C17H14Cl2N2OS, CAS 318248-40-7](/s/NOWWLOKUBAFHDO-UHFFFAOYSA-N.svg)
{5-[(2,6-Dichlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol
CAS 318248-40-7C17H14Cl2N2OS
![{5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl acetate chemical structure, C19H17ClN2O2S, CAS 318289-52-0](/s/JLKINBOZIAWNSL-UHFFFAOYSA-N.svg)
{5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl acetate
CAS 318289-52-0C19H17ClN2O2S
![{5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl methyl ether chemical structure, C18H17ClN2OS, CAS 318289-56-4](/s/RPDXVZVNBXOUCI-UHFFFAOYSA-N.svg)
{5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methyl methyl ether
CAS 318289-56-4C18H17ClN2OS
![5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile chemical structure, C17H12BrN3S, CAS 321998-64-5](/s/LMLJJAQLXHUVIU-UHFFFAOYSA-N.svg)
5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile
CAS 321998-64-5C17H12BrN3S
![Methyl 2-[(4-cyano-1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfanyl]benzenecarboxylate chemical structure, C19H15N3O2S, CAS 321998-66-7](/s/RHDWBYRBEAOGPG-UHFFFAOYSA-N.svg)
Methyl 2-[(4-cyano-1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfanyl]benzenecarboxylate
CAS 321998-66-7C19H15N3O2S
![1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C18H16N2OS, CAS 318233-98-6](/s/XESMSCMMPAMZLI-UHFFFAOYSA-N.svg)
1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazole-4-carbaldehyde
CAS 318233-98-6C18H16N2OS
![{1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methanol chemical structure, C18H18N2OS, CAS 318233-99-7](/s/BALJAALTXMAPOH-UHFFFAOYSA-N.svg)
{1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methanol
CAS 318233-99-7C18H18N2OS
![Methyl 2-{[4-(hydroxymethyl)-1-methyl-3-phenyl-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate chemical structure, C19H18N2O3S, CAS 318234-06-9](/s/JTIKWIDDNYIGJN-UHFFFAOYSA-N.svg)
Methyl 2-{[4-(hydroxymethyl)-1-methyl-3-phenyl-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate
CAS 318234-06-9C19H18N2O3S
![5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C17H13ClN2OS, CAS 318247-49-3](/s/MUCQXWPJYOUCQJ-UHFFFAOYSA-N.svg)
5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde
CAS 318247-49-3C17H13ClN2OS
1-Methyl-3-phenyl-5-(phenylsulfanyl)-1H-pyrazole-4-carbaldehyde
CAS 318247-51-7C17H14N2OS
- {5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol318247-53-9C17H15ClN2OS
- {5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methanol318247-54-0C17H15ClN2OS
- [1-Methyl-3-phenyl-5-(phenylsulfanyl)-1H-pyrazol-4-yl]methanol318247-55-1C17H16N2OS
- 4-(Chloromethyl)-5-[(2-chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole318289-54-2C17H14Cl2N2S
- 4-Bromophenyl 4-(chloromethyl)-1-methyl-3-phenyl-1H-pyrazol-5-yl sulfide318959-24-9C17H14BrClN2S
- 5-{[4-(tert-Butyl)phenyl]sulfanyl}-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde321998-18-9C21H22N2OS
- 5-[(4-Methoxyphenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde321998-19-0C18H16N2O2S
- 5-{[4-(tert-Butyl)phenyl]sulfanyl}-1-methyl-3-phenyl-1H-pyrazole-4-carbonitrile321998-38-3C21H21N3S
- 1-[1-Methyl-3-phenyl-5-(phenylsulfanyl)-1H-pyrazol-4-yl]-2-heptyn-1-ol318949-14-3C23H24N2OS
- 4-(Chloromethyl)-5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole318247-65-3C17H14Cl2N2S
- 5-(2,6-Dichlorophenyl)sulfanyl-1-methyl-3-phenyl-4-(prop-2-enoxymethyl)pyrazole318248-43-0C20H18Cl2N2OS
- 4-(Chloromethyl)-5-[(2,6-dichlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole318248-41-8C17H13Cl3N2S
- 5-[(2,6-Dichlorophenyl)sulfanyl]-4-(methoxymethyl)-1-methyl-3-phenyl-1H-pyrazole318248-42-9C18H16Cl2N2OS
- 1-{5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}hept-2-yn-1-ol318949-15-4C23H23ClN2OS
- 1-{1-Methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}-2-heptyn-1-ol318949-13-2C24H26N2OS
- 1-Methyl-3-phenyl-5-(phenylsulfanyl)-1H-pyrazole-4-carbaldehyde oxime321998-16-7C17H15N3OS
- 5-[(4-Methoxyphenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde oxime321998-21-4C18H17N3O2S
- 5-[(4-Bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde oxime321998-39-4C17H14BrN3OS
- 5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde oxime321998-17-8C17H14ClN3OS
- 5-{[4-(tert-Butyl)phenyl]sulfanyl}-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde oxime321998-20-3C21H23N3OS
- 5-[(2-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde oxime321998-22-5C17H14ClN3OS
- 1-Methyl-3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazole-4-carbaldehyde oxime321998-23-6C18H14F3N3OS
- 5-[(4-Chlorophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazole-4-carbaldehyde O-methyloxime321998-45-2C18H16ClN3OS
- Methyl 2-({4-[(methoxyimino)methyl]-1-methyl-3-phenyl-1H-pyrazol-5-yl}sulfanyl)benzenecarboxylate303984-98-7C20H19N3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1ccccc1)c1cnn(-c2ccccc2)c161 chemicals
c1ccc(Nc2nc(-c3ccccc3)cs2)cc149 chemicals
O=C1CC(Sc2ncccn2)C(=O)N1c1ccccc138 chemicals
c1ccc(Cn2ccc(-c3ccccc3)n2)cc136 chemicals
O=C1CC(Sc2ccccc2)C(=O)N1c1ccccc131 chemicals
O=C1CC(Nc2ccccc2)C(=O)N1c1ccccc131 chemicals
O=C1OC(c2ccccc2)=NC1=Cc1ccccc125 chemicals
O=S(=O)(c1ccccc1)c1coc(-c2ccccc2)n119 chemicals
c1ccc(-c2csc(Nc3ccccn3)n2)cc117 chemicals
O=C1C(=Cc2ccccc2)C=NN1c1ccccc115 chemicals
O=C1CC(Sc2ccccn2)C(=O)N1c1ccccc113 chemicals
O=C1CC(Cc2ccccc2)C(=O)N1c1ccccc113 chemicals