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Murcko scaffold

Ring system with 3 rings and 22 atoms

113 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
113
With full pages
4
Scaffold SMILES

O=C(NCCc1cnc(-c2ccccc2)s1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCc1cnc(-c2ccccc2)s1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 113 chemicals

N-{2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}-3-(trifluoromethyl)benzamide chemical structure, C21H19F3N2O2S, CAS 893995-81-8
N-{2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}-3-(trifluoromethyl)benzamide
CAS 893995-81-8C21H19F3N2O2S
2,6-Difluoro-N-{2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H18F2N2OS, CAS 890955-48-3
2,6-Difluoro-N-{2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 890955-48-3C20H18F2N2OS
4-Methoxy-N-{2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C21H22N2O2S, CAS 873076-11-0
4-Methoxy-N-{2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 873076-11-0C21H22N2O2S
3-Methoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C20H20N2O2S, CAS 893352-82-4
3-Methoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893352-82-4C20H20N2O2S
3,4,5-Trimethoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C22H24N2O4S, CAS 893352-96-0
3,4,5-Trimethoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893352-96-0C22H24N2O4S
N-{2-[2-(3,4-Dimethoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C21H22N2O3S, CAS 893359-12-1
N-{2-[2-(3,4-Dimethoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893359-12-1C21H22N2O3S
N-{2-[4-Methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H20N2OS, CAS 893360-54-8
N-{2-[4-Methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893360-54-8C20H20N2OS
3,4-Dimethoxy-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C22H24N2O3S, CAS 893361-11-0
3,4-Dimethoxy-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893361-11-0C22H24N2O3S
3-Chloro-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H19ClN2OS, CAS 893997-53-0
3-Chloro-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893997-53-0C20H19ClN2OS
3-Methyl-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C21H22N2OS, CAS 893997-65-4
3-Methyl-N-{2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893997-65-4C21H22N2OS
N-{2-[2-(4-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C19H17FN2OS, CAS 894001-98-0
N-{2-[2-(4-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide
CAS 894001-98-0C19H17FN2OS
N-{2-[2-(4-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}-3,4-dimethoxybenzamide chemical structure, C21H21FN2O3S, CAS 894002-40-5
N-{2-[2-(4-Fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}-3,4-dimethoxybenzamide
CAS 894002-40-5C21H21FN2O3S
2-Bromo-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C19H17BrN2OS, CAS 893995-23-8
2-Bromo-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-23-8C19H17BrN2OS
4-Chloro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C19H17ClN2OS, CAS 893995-29-4
4-Chloro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-29-4C19H17ClN2OS
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-4-nitrobenzamide chemical structure, C19H17N3O3S, CAS 890955-07-4
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-4-nitrobenzamide
CAS 890955-07-4C19H17N3O3S
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-3-nitrobenzamide chemical structure, C19H17N3O3S, CAS 890955-14-3
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-3-nitrobenzamide
CAS 890955-14-3C19H17N3O3S
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-3-(trifluoromethyl)benzamide chemical structure, C20H17F3N2OS, CAS 893995-33-0
N-[2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]-3-(trifluoromethyl)benzamide
CAS 893995-33-0C20H17F3N2OS
4-Ethoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C21H22N2O2S, CAS 893995-38-5
4-Ethoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-38-5C21H22N2O2S
4-Methoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C20H20N2O2S, CAS 893995-44-3
4-Methoxy-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-44-3C20H20N2O2S
4-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C20H20N2OS, CAS 893995-50-1
4-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-50-1C20H20N2OS
3-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide chemical structure, C20H20N2OS, CAS 893995-55-6
3-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzamide
CAS 893995-55-6C20H20N2OS
4-Chloro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H19ClN2O2S, CAS 873010-81-2
4-Chloro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide
CAS 873010-81-2C20H19ClN2O2S
3-Chloro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H19ClN2O2S, CAS 893995-70-5
3-Chloro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide
CAS 893995-70-5C20H19ClN2O2S
3,4-Difluoro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide chemical structure, C20H18F2N2O2S, CAS 873076-00-7
3,4-Difluoro-N-{2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}benzamide
CAS 873076-00-7C20H18F2N2O2S