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Murcko scaffold

Ring system with 3 rings and 23 atoms

199 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
199
With full pages
3
Scaffold SMILES

O=C(CSc1nnc(Cc2ccccc2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(Cc2ccccc2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 199 chemicals

2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[4-bromo-2-(trifluoromethyl)phenyl]acetamide chemical structure, C19H16BrF3N4OS, CAS 663214-92-4
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[4-bromo-2-(trifluoromethyl)phenyl]acetamide
CAS 663214-92-4C19H16BrF3N4OS
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromo-2-fluorophenyl)acetamide chemical structure, C18H16BrFN4OS, CAS 663214-94-6
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromo-2-fluorophenyl)acetamide
CAS 663214-94-6C18H16BrFN4OS
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-chloro-4-fluorophenyl)acetamide chemical structure, C18H16ClFN4OS, CAS 663214-04-8
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-chloro-4-fluorophenyl)acetamide
CAS 663214-04-8C18H16ClFN4OS
2-[(5-Benzyl-4-propyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-bromo-4-methylphenyl)acetamide chemical structure, C21H23BrN4OS, CAS 663214-28-6
2-[(5-Benzyl-4-propyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-bromo-4-methylphenyl)acetamide
CAS 663214-28-6C21H23BrN4OS
N-(4-Iodo-2-methylphenyl)-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C20H21IN4O2S, CAS 665016-79-5
N-(4-Iodo-2-methylphenyl)-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 665016-79-5C20H21IN4O2S
N-(2,4-Dichlorophenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C19H18Cl2N4O2S, CAS 665016-82-0
N-(2,4-Dichlorophenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 665016-82-0C19H18Cl2N4O2S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C20H18ClF3N4O2S, CAS 665016-85-3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 665016-85-3C20H18ClF3N4O2S
N-(2-Methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C20H22N4O3S, CAS 693230-58-9
N-(2-Methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 693230-58-9C20H22N4O3S
N-(4-Bromo-2-fluorophenyl)-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H18BrFN4O2S, CAS 665018-16-6
N-(4-Bromo-2-fluorophenyl)-2-{[5-(4-methoxybenzyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 665018-16-6C19H18BrFN4O2S
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromo-2,3-dimethylphenyl)acetamide chemical structure, C20H21BrN4OS, CAS 665018-24-6
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromo-2,3-dimethylphenyl)acetamide
CAS 665018-24-6C20H21BrN4OS
Methyl 4-({[(5-benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}amino)benzoate chemical structure, C20H20N4O3S, CAS 626204-66-8
Methyl 4-({[(5-benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}amino)benzoate
CAS 626204-66-8C20H20N4O3S
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2,3-dimethylphenyl)acetamide chemical structure, C21H24N4OS, CAS 482643-30-1
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2,3-dimethylphenyl)acetamide
CAS 482643-30-1C21H24N4OS
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromophenyl)acetamide chemical structure, C18H17BrN4OS, CAS 333323-54-9
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-bromophenyl)acetamide
CAS 333323-54-9C18H17BrN4OS
2-((3-Benzyl-1H-1,2,4-triazol-5-yl)thio)-N-(2-bromophenyl)acetamide chemical structure, C17H15BrN4OS, CAS 332127-33-0
2-((3-Benzyl-1H-1,2,4-triazol-5-yl)thio)-N-(2-bromophenyl)acetamide
CAS 332127-33-0C17H15BrN4OS
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H20N4O2S, CAS 298215-21-1
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 298215-21-1C19H20N4O2S
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide chemical structure, C18H17ClN4OS, CAS 332946-48-2
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-chlorophenyl)acetamide
CAS 332946-48-2C18H17ClN4OS
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-ethoxyphenyl)acetamide chemical structure, C21H24N4O2S, CAS 332946-49-3
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-ethoxyphenyl)acetamide
CAS 332946-49-3C21H24N4O2S
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C20H22N4O2S, CAS 332946-52-8
2-[(5-Benzyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 332946-52-8C20H22N4O2S
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4-difluorophenyl)acetamide chemical structure, C18H16F2N4OS, CAS 298215-08-4
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4-difluorophenyl)acetamide
CAS 298215-08-4C18H16F2N4OS
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3-nitrophenyl)acetamide chemical structure, C18H17N5O3S, CAS 298218-09-4
2-[(5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3-nitrophenyl)acetamide
CAS 298218-09-4C18H17N5O3S
2-[(5-Benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-bromophenyl)acetamide chemical structure, C20H19BrN4OS, CAS 713493-77-7
2-[(5-Benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-bromophenyl)acetamide
CAS 713493-77-7C20H19BrN4OS
2-((5-((3,4-Dimethoxyphenyl)methyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C21H24N4O4S, CAS 298217-98-8
2-((5-((3,4-Dimethoxyphenyl)methyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 298217-98-8C21H24N4O4S
2-[(5-Benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C22H26N4OS, CAS 694461-78-4
2-[(5-Benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide
CAS 694461-78-4C22H26N4OS
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4,6-trichlorophenyl)acetamide chemical structure, C18H15Cl3N4OS, CAS 694462-03-8
2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4,6-trichlorophenyl)acetamide
CAS 694462-03-8C18H15Cl3N4OS