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Murcko scaffold

Ring system with 3 rings and 22 atoms

90 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
90
With full pages
8
Scaffold SMILES

O=C(CCc1nc(-c2ccccc2)no1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCc1nc(-c2ccccc2)no1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 90 chemicals

3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methylphenyl)propanamide chemical structure, C19H19N3O3, CAS 862208-10-4
3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methylphenyl)propanamide
CAS 862208-10-4C19H19N3O3
Ethyl 4-(3-(3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)propanamido)benzoate chemical structure, C20H18ClN3O4, CAS 864935-42-2
Ethyl 4-(3-(3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)propanamido)benzoate
CAS 864935-42-2C20H18ClN3O4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-3-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C19H15ClF3N3O3, CAS 838273-39-5
N-[2-Chloro-5-(trifluoromethyl)phenyl]-3-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 838273-39-5C19H15ClF3N3O3
N-(3-Chlorophenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16ClN3O2, CAS 831198-39-1
N-(3-Chlorophenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831198-39-1C18H16ClN3O2
N-(3-Methoxyphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C19H19N3O3, CAS 831193-85-2
N-(3-Methoxyphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831193-85-2C19H19N3O3
3-[3-(2-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methoxyphenyl)propanamide chemical structure, C18H16FN3O3, CAS 831193-96-5
3-[3-(2-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methoxyphenyl)propanamide
CAS 831193-96-5C18H16FN3O3
3-[3-(2-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methylphenyl)propanamide chemical structure, C18H16FN3O2, CAS 831240-37-0
3-[3-(2-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methylphenyl)propanamide
CAS 831240-37-0C18H16FN3O2
N-(4-Fluorophenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16FN3O3, CAS 850751-60-9
N-(4-Fluorophenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 850751-60-9C18H16FN3O3
N-(2-Fluorophenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16FN3O3, CAS 877787-61-6
N-(2-Fluorophenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 877787-61-6C18H16FN3O3
3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methylphenyl)propanamide chemical structure, C19H19N3O3, CAS 877779-20-9
3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(2-methylphenyl)propanamide
CAS 877779-20-9C19H19N3O3
3-[3-(4-tert-Butylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-ethoxyphenyl)propanamide chemical structure, C23H27N3O3, CAS 831187-98-5
3-[3-(4-tert-Butylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-ethoxyphenyl)propanamide
CAS 831187-98-5C23H27N3O3
N-(4-Methoxyphenyl)-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanamide chemical structure, C18H17N3O3, CAS 831193-45-4
N-(4-Methoxyphenyl)-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanamide
CAS 831193-45-4C18H17N3O3
N-(3,4-Dimethylphenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C20H21N3O3, CAS 831199-62-3
N-(3,4-Dimethylphenyl)-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831199-62-3C20H21N3O3
N-(4-Chlorophenyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16ClN3O2, CAS 831200-01-2
N-(4-Chlorophenyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831200-01-2C18H16ClN3O2
N-(2-Chlorophenyl)-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanamide chemical structure, C17H14ClN3O2, CAS 831207-12-6
N-(2-Chlorophenyl)-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanamide
CAS 831207-12-6C17H14ClN3O2
3-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methoxyphenyl)propanamide chemical structure, C20H21N3O5, CAS 831211-12-2
3-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methoxyphenyl)propanamide
CAS 831211-12-2C20H21N3O5
3-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-nitrophenyl)propanamide chemical structure, C18H16N4O4, CAS 831236-71-6
3-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(3-nitrophenyl)propanamide
CAS 831236-71-6C18H16N4O4
N-(2,3-Dimethylphenyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C20H21N3O2, CAS 831239-46-4
N-(2,3-Dimethylphenyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831239-46-4C20H21N3O2
N-(2,3-Dimethylphenyl)-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}propanamide chemical structure, C20H18F3N3O2, CAS 866040-01-9
N-(2,3-Dimethylphenyl)-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}propanamide
CAS 866040-01-9C20H18F3N3O2
4-[3-[3-(2-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoylamino]benzamide chemical structure, C19H18N4O4, CAS 864936-31-2
4-[3-[3-(2-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoylamino]benzamide
CAS 864936-31-2C19H18N4O4
N-(2-Fluorophenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16FN3O2, CAS 831179-52-3
N-(2-Fluorophenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831179-52-3C18H16FN3O2
N-(2-Chlorophenyl)-3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C18H16ClN3O3, CAS 831237-36-6
N-(2-Chlorophenyl)-3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 831237-36-6C18H16ClN3O3
N-(4-Acetamidophenyl)-3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide chemical structure, C20H20N4O4, CAS 835897-64-8
N-(4-Acetamidophenyl)-3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide
CAS 835897-64-8C20H20N4O4
3-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-[2-(trifluoromethyl)phenyl]propanamide chemical structure, C20H18F3N3O4, CAS 838608-58-5
3-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-N-[2-(trifluoromethyl)phenyl]propanamide
CAS 838608-58-5C20H18F3N3O4