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Murcko scaffold

Ring system with 3 rings and 22 atoms

97 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
97
With full pages
5
Scaffold SMILES

O=C(COc1ccccc1)Nc1nc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1nc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

2-(4-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C17H13ClN2O2S, CAS 37666-23-2
2-(4-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 37666-23-2C17H13ClN2O2S
2-(3-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C17H13ClN2O2S, CAS 307536-51-2
2-(3-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 307536-51-2C17H13ClN2O2S
2-(4-Methoxyphenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C18H16N2O3S, CAS 307536-47-6
2-(4-Methoxyphenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 307536-47-6C18H16N2O3S
N-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide chemical structure, C18H16N2O3S, CAS 536732-06-6
N-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide
CAS 536732-06-6C18H16N2O3S
2-(2-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C17H13ClN2O2S, CAS 72192-37-1
2-(2-Chlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 72192-37-1C17H13ClN2O2S
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide chemical structure, C17H13FN2O2S, CAS 313469-61-3
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide
CAS 313469-61-3C17H13FN2O2S
2-(2-Methylphenoxy)-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C19H18N2O2S, CAS 433247-08-6
2-(2-Methylphenoxy)-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 433247-08-6C19H18N2O2S
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide chemical structure, C19H18N2O2S, CAS 444937-04-6
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-phenoxyacetamide
CAS 444937-04-6C19H18N2O2S
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2-(2-methylphenoxy)acetamide chemical structure, C18H15FN2O2S, CAS 460998-71-4
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2-(2-methylphenoxy)acetamide
CAS 460998-71-4C18H15FN2O2S
N-(5-Methyl-4-phenyl-1,3-thiazol-2-yl)-2-phenoxyacetamide chemical structure, C18H16N2O2S, CAS 72192-51-9
N-(5-Methyl-4-phenyl-1,3-thiazol-2-yl)-2-phenoxyacetamide
CAS 72192-51-9C18H16N2O2S
2-(4-Chlorophenoxy)-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C17H12Cl2N2O2S, CAS 373369-60-9
2-(4-Chlorophenoxy)-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide
CAS 373369-60-9C17H12Cl2N2O2S
N-[4-(2,5-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(3,4-dimethylphenoxy)acetamide chemical structure, C21H22N2O4S, CAS 438198-06-2
N-[4-(2,5-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(3,4-dimethylphenoxy)acetamide
CAS 438198-06-2C21H22N2O4S
2-(2-Chlorophenoxy)-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C18H15ClN2O2S, CAS 72192-49-5
2-(2-Chlorophenoxy)-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 72192-49-5C18H15ClN2O2S
2-(3,4-Dichlorophenoxy)-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]acetamide chemical structure, C20H18Cl2N2O2S, CAS 512825-71-7
2-(3,4-Dichlorophenoxy)-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]acetamide
CAS 512825-71-7C20H18Cl2N2O2S
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenoxy)acetamide chemical structure, C20H20N2O3S, CAS 352700-81-3
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenoxy)acetamide
CAS 352700-81-3C20H20N2O3S
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenoxy)acetamide chemical structure, C19H17FN2O2S, CAS 353787-45-8
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenoxy)acetamide
CAS 353787-45-8C19H17FN2O2S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenoxy)acetamide chemical structure, C17H12BrFN2O2S, CAS 445252-75-5
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenoxy)acetamide
CAS 445252-75-5C17H12BrFN2O2S
2-(4-Chlorophenoxy)-N-(4-(4-nitrophenyl)thiazol-2-yl)acetamide chemical structure, C17H12ClN3O4S, CAS 313469-53-3
2-(4-Chlorophenoxy)-N-(4-(4-nitrophenyl)thiazol-2-yl)acetamide
CAS 313469-53-3C17H12ClN3O4S
2-(2-Bromo-4-methylphenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C18H15BrN2O2S, CAS 307536-53-4
2-(2-Bromo-4-methylphenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 307536-53-4C18H15BrN2O2S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-chloro-2-methylphenoxy)acetamide chemical structure, C18H14BrClN2O2S, CAS 329225-94-7
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(4-chloro-2-methylphenoxy)acetamide
CAS 329225-94-7C18H14BrClN2O2S
2-(2,4-Dichlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C17H12Cl2N2O2S, CAS 199602-20-5
2-(2,4-Dichlorophenoxy)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 199602-20-5C17H12Cl2N2O2S
2-(2-tert-Butylphenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C22H24N2O2S, CAS 347364-67-4
2-(2-tert-Butylphenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 347364-67-4C22H24N2O2S
2-(2-Bromo-4-methylphenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C19H17BrN2O2S, CAS 347366-64-7
2-(2-Bromo-4-methylphenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 347366-64-7C19H17BrN2O2S
N-[4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-yl]-2-(2-chlorophenoxy)acetamide chemical structure, C18H14BrClN2O3S, CAS 333774-21-3
N-[4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-yl]-2-(2-chlorophenoxy)acetamide
CAS 333774-21-3C18H14BrClN2O3S