Murcko scaffold
1-Phenyl-4-(pyridin-3-ylmethyl)piperazine scaffold
43 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 19
- Chemicals
- 43
- With full pages
- 7
Scaffold SMILES
c1ccc(N2CCN(Cc3cccnc3)CC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 43 of 43 chemicals
![1-(4-{4-[(Pyridin-3-yl)methyl]piperazin-1-yl}phenyl)ethan-1-one chemical structure, C18H21N3O, CAS 415712-72-0](/s/ZNGSLVXDSMCIAL-UHFFFAOYSA-N.svg)
1-(4-{4-[(Pyridin-3-yl)methyl]piperazin-1-yl}phenyl)ethan-1-one
CAS 415712-72-0C18H21N3O
1-(2-Chlorophenyl)-4-(pyridin-3-ylmethyl)piperazine
CAS 331977-19-6C16H18ClN3
1-(2-Methylphenyl)-4-(pyridin-3-ylmethyl)piperazine
CAS 331854-59-2C17H21N3
![1-[(6-Chloro-3-pyridinyl)methyl]-4-(2,6-dimethylphenyl)piperazine chemical structure, C18H22ClN3, CAS 861211-43-0](/s/VNJFRVCGHPNPOD-UHFFFAOYSA-N.svg)
1-[(6-Chloro-3-pyridinyl)methyl]-4-(2,6-dimethylphenyl)piperazine
CAS 861211-43-0C18H22ClN3
![1-[(6-Chloro-3-pyridinyl)methyl]-4-phenylpiperazine chemical structure, C16H18ClN3, CAS 860787-10-6](/s/PTUJECVYMIOYMK-UHFFFAOYSA-N.svg)
1-[(6-Chloro-3-pyridinyl)methyl]-4-phenylpiperazine
CAS 860787-10-6C16H18ClN3
![1-[(6-Chloropyridin-3-yl)methyl]-4-(4-methoxyphenyl)piperazine chemical structure, C17H20ClN3O, CAS 478048-49-6](/s/NFHUSYOGRUGFAV-UHFFFAOYSA-N.svg)
1-[(6-Chloropyridin-3-yl)methyl]-4-(4-methoxyphenyl)piperazine
CAS 478048-49-6C17H20ClN3O
![1-[(6-Chloropyridin-3-yl)methyl]-4-(4-fluorophenyl)piperazine chemical structure, C16H17ClFN3, CAS 478048-50-9](/s/SBMUCHKVJQOEOS-UHFFFAOYSA-N.svg)
1-[(6-Chloropyridin-3-yl)methyl]-4-(4-fluorophenyl)piperazine
CAS 478048-50-9C16H17ClFN3
![1-(2-Methoxyphenyl)-4-[(pyridin-3-yl)methyl]piperazine chemical structure, C17H21N3O, CAS 414883-30-0](/s/NIOCEAQPJHBDGN-UHFFFAOYSA-N.svg)
1-(2-Methoxyphenyl)-4-[(pyridin-3-yl)methyl]piperazine
CAS 414883-30-0C17H21N3O
![N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide chemical structure, C19H25FN4O2S, CAS 863586-63-4](/s/WTIYVMQJWGIYGC-UHFFFAOYSA-N.svg)
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide
CAS 863586-63-4C19H25FN4O2S
![N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide chemical structure, C19H25FN4O2S, CAS 863586-84-9](/s/ASYJCMQQNDMWCL-UHFFFAOYSA-N.svg)
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide
CAS 863586-84-9C19H25FN4O2S
![N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(pyridin-3-yl)ethyl}methanesulfonamide chemical structure, C18H23FN4O2S, CAS 863586-55-4](/s/ZDKITXZGLDKMPV-UHFFFAOYSA-N.svg)
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(pyridin-3-yl)ethyl}methanesulfonamide
CAS 863586-55-4C18H23FN4O2S
1-(4-Fluorophenyl)-4-(pyridin-3-ylmethyl)piperazine
CAS 331855-67-5C16H18FN3
1-Phenyl-4-(pyridin-3-ylmethyl)piperazine
CAS 58013-18-6C16H19N3
![N-[2-(4-Phenylpiperazin-1-yl)-2-pyridin-3-ylethyl]ethanesulfonamide chemical structure, C19H26N4O2S, CAS 863558-76-3](/s/BRJQHSGBDMQDFB-UHFFFAOYSA-N.svg)
N-[2-(4-Phenylpiperazin-1-yl)-2-pyridin-3-ylethyl]ethanesulfonamide
CAS 863558-76-3C19H26N4O2S
![N-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide chemical structure, C20H28N4O3S, CAS 863558-86-5](/s/LRRYNXBVNDKKGG-UHFFFAOYSA-N.svg)
N-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]ethanesulfonamide
CAS 863558-86-5C20H28N4O3S
![N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]methanesulfonamide chemical structure, C18H23FN4O2S, CAS 863586-77-0](/s/SCJQJQBMEMSXAK-UHFFFAOYSA-N.svg)
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-pyridin-3-ylethyl]methanesulfonamide
CAS 863586-77-0C18H23FN4O2S
4-(4-Pyridin-3-ylmethylpiperazin-1-yl)benzonitrile
CAS 617691-08-4C17H18N4
N1-(2-(dimethylamino)ethyl)-N2-(2-(4-phenylpiperazin-1-yl)-2-(pyridin-3-yl)ethyl)oxalamide
CAS 863556-77-8C23H32N6O2
![N-(2-Methoxyethyl)-N'-[2-(4-phenylpiperazin-1-yl)-2-(pyridin-3-yl)ethyl]ethanediamide chemical structure, C22H29N5O3, CAS 863556-78-9](/s/DNZNADGMJRBVHM-UHFFFAOYSA-N.svg)
N-(2-Methoxyethyl)-N'-[2-(4-phenylpiperazin-1-yl)-2-(pyridin-3-yl)ethyl]ethanediamide
CAS 863556-78-9C22H29N5O3
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(pyridin-3-yl)ethyl)-N2-(2-methoxyethyl)oxalamide
CAS 863558-11-6C22H28FN5O3
N1-(2-(dimethylamino)ethyl)-N2-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(pyridin-3-yl)ethyl)oxalamide
CAS 863558-10-5C23H31FN6O2
![{4-[4-(3-Pyridylmethyl)piperazinyl]phenyl}methylamine chemical structure, C17H22N4, CAS 937598-56-6](/s/ATIKETOTCKBLID-UHFFFAOYSA-N.svg)
{4-[4-(3-Pyridylmethyl)piperazinyl]phenyl}methylamine
CAS 937598-56-6C17H22N4
![2-[4-(3-Pyridinylmethyl)-1-piperazinyl]benzenemethanamine chemical structure, C17H22N4, CAS 937599-73-0](/s/CQIQRWJGKGEBHX-UHFFFAOYSA-N.svg)
2-[4-(3-Pyridinylmethyl)-1-piperazinyl]benzenemethanamine
CAS 937599-73-0C17H22N4
N1-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-(pyridin-3-yl)ethyl)-N2-isobutyloxalamide
CAS 863557-94-2C23H30FN5O2
- N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(pyridin-3-yl)ethyl)-N2-isobutyloxalamide863558-32-1C23H30FN5O2
- 1-(2-Chloro-4-methyl-5-methylsulfonylphenyl)-4-[[6-(trifluoromethyl)-3-pyridinyl]methyl]piperazine909666-43-9C19H21ClF3N3O2S
- 1-[2-Chloro-4-(methylsulfonyl)phenyl]-4-{[6-(trifluoromethyl)-3-pyridinyl]methyl}piperazine909666-46-2C18H19ClF3N3O2S
- 1-[4-Chloro-2-(methylsulfonyl)phenyl]-4-{[6-(trifluoromethyl)-3-pyridinyl]methyl}piperazine909666-49-5C18H19ClF3N3O2S
- 1-(2,3-Dichlorophenyl)-4-[(pyridin-3-yl)methyl]piperazine1451194-24-3C16H17Cl2N3
- [4-(4-Fluoro-phenyl)-piperazin-1-yl]-pyridin-3-YL-acetic acid885276-69-7C17H18FN3O2
- [4-(4-Chloro-phenyl)-piperazin-1-yl]-pyridin-3-YL-acetic acid885276-88-0C17H18ClN3O2
- 1-[(6-Chloro-3-pyridinyl)methyl]-4-(3-methoxyphenyl)piperazine1146954-93-9C17H20ClN3O
- 1-(4-Bromophenyl)-4-[(pyridin-3-yl)methyl]piperazine2877652-04-3C16H18BrN3
- 1-(3-Bromophenyl)-4-[(pyridin-3-yl)methyl]piperazine2770621-85-5C16H18BrN3
- 1-(3-Methoxyphenyl)-4-[(4-methylpyridin-3-yl)methyl]piperazine3030807-49-6C18H23N3O
- 1-(2-Fluorophenyl)-4-[(4-methylpyridin-3-yl)methyl]piperazine3030805-70-7C17H20FN3
- 1-(2,4-Difluorophenyl)-4-[(4-methylpyridin-3-yl)methyl]piperazine3030805-78-5C17H19F2N3
- 1-(2,5-Dimethylphenyl)-4-[(4-methylpyridin-3-yl)methyl]piperazine3030830-62-4C19H25N3
- 4-{4-[(4-Methylpyridin-3-yl)methyl]piperazin-1-yl}benzene-1-sulfonamide3054602-77-3C17H22N4O2S
- 4-{4-[(2-Methylpyridin-3-yl)methyl]piperazin-1-yl}benzene-1-sulfonamide3054564-91-6C17H22N4O2S
- 4-{4-[(Pyridin-3-yl)methyl]piperazin-1-yl}benzene-1-sulfonamide3054416-54-2C16H20N4O2S
- 4-{4-[(5-Fluoropyridin-3-yl)methyl]piperazin-1-yl}benzene-1-sulfonamide3054633-01-8C16H19FN4O2S
- 4-{4-[(5-Bromopyridin-3-yl)methyl]piperazin-1-yl}benzene-1-sulfonamide3054585-74-6C16H19BrN4O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1ccccc1)N1CCN(c2ccccc2)CC1177 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ccccc2)CC1130 chemicals
c1ccc(CN2CCN(c3ccccc3)CC2)cc140 chemicals
O=c1ccoc(CN2CCN(c3ccccc3)CC2)c130 chemicals
O=C(c1ccccc1)N1CCN(c2ccccn2)CC129 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ccccn2)CC124 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ncccn2)CC115 chemicals![Scaffold O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]1](/scaffold/NDLNPZDGZZJEQK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]114 chemicals
O=C(N1CCOCC1)N1CCN(c2ccccc2)CC113 chemicals
S=C(c1ccccc1)N1CCN(c2ccccc2)CC113 chemicals
c1ccc(CN2CCN(c3ccccn3)CC2)cc112 chemicals
O=C(c1ccccc1)N1CCN(c2ncccn2)CC112 chemicals