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Murcko scaffold

Ring system with 3 rings and 18 atoms

321 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
321
With full pages
9
Scaffold SMILES

c1ccc(CN2CCC(c3ccccc3)C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CN2CCC(c3ccccc3)C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 321 chemicals

Phenol, 3-(1-benzyl-3-propyl-3-pyrrolidinyl)- chemical structure, C20H25NO, CAS 28066-75-3
Phenol, 3-(1-benzyl-3-propyl-3-pyrrolidinyl)-
CAS 28066-75-3C20H25NO
1-Benzyl-3-(4-fluorophenyl)pyrrolidin-3-ol chemical structure, C17H18FNO, CAS 425663-33-8
1-Benzyl-3-(4-fluorophenyl)pyrrolidin-3-ol
CAS 425663-33-8C17H18FNO
(3R,4S)-1-Benzyl-4-phenylpyrrolidine-3-carboxylic acid chemical structure, C18H19NO2, CAS 1201574-92-6
(3R,4S)-1-Benzyl-4-phenylpyrrolidine-3-carboxylic acid
CAS 1201574-92-6C18H19NO2
(3R,4S)-1-Benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid chemical structure, C18H18N2O4, CAS 154205-80-8
(3R,4S)-1-Benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid
CAS 154205-80-8C18H18N2O4
(3R,4S)-1-Benzyl-4-phenylpyrrolidine-3-carbonitrile chemical structure, C18H18N2, CAS 1201575-00-9
(3R,4S)-1-Benzyl-4-phenylpyrrolidine-3-carbonitrile
CAS 1201575-00-9C18H18N2
Trans-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid chemical structure, C18H18ClNO2, CAS 80896-74-8
Trans-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid
CAS 80896-74-8C18H18ClNO2
1-Benzyl-3-(3-methoxyphenyl)-3-propylpyrrolidine chemical structure, C21H27NO, CAS 69440-53-5
1-Benzyl-3-(3-methoxyphenyl)-3-propylpyrrolidine
CAS 69440-53-5C21H27NO
1-Benzyl-4-phenyl-pyrrolidine-3-carboxylic acid chemical structure, C18H19NO2, CAS 885958-91-8
1-Benzyl-4-phenyl-pyrrolidine-3-carboxylic acid
CAS 885958-91-8C18H19NO2
1-Benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid chemical structure, C18H18ClNO2, CAS 885959-10-4
1-Benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid
CAS 885959-10-4C18H18ClNO2
1-Benzyl-3-(4-fluorophenyl)pyrrolidine chemical structure, C17H18FN, CAS 220474-60-2
1-Benzyl-3-(4-fluorophenyl)pyrrolidine
CAS 220474-60-2C17H18FN
1-Benzyl-3-(p-tolyl)pyrrolidine chemical structure, C18H21N, CAS 220474-58-8
1-Benzyl-3-(p-tolyl)pyrrolidine
CAS 220474-58-8C18H21N
1-Benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid chemical structure, C18H18N2O4, CAS 885958-95-2
1-Benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid
CAS 885958-95-2C18H18N2O4
Ethyl 1-benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylate chemical structure, C20H22N2O4, CAS 306305-35-1
Ethyl 1-benzyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylate
CAS 306305-35-1C20H22N2O4
1-Benzyl-4-(4-bromophenyl)pyrrolidine-3-carboxylic acid chemical structure, C18H18BrNO2, CAS 885959-06-8
1-Benzyl-4-(4-bromophenyl)pyrrolidine-3-carboxylic acid
CAS 885959-06-8C18H18BrNO2
1-Benzyl-4-phenylpyrrolidine-3-carbonitrile chemical structure, C18H18N2, CAS 115687-28-0
1-Benzyl-4-phenylpyrrolidine-3-carbonitrile
CAS 115687-28-0C18H18N2
1-Benzyl-3-phenylpyrrolidin-3-ol chemical structure, C17H19NO, CAS 23771-98-4
1-Benzyl-3-phenylpyrrolidin-3-ol
CAS 23771-98-4C17H19NO
1-Benzyl-4-(4-bromo-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester chemical structure, C20H22BrNO2, CAS 883993-84-8
1-Benzyl-4-(4-bromo-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester
CAS 883993-84-8C20H22BrNO2
(3S,4S)-1-Benzyl-4-phenylpyrrolidine-3-carbonitrile chemical structure, C18H18N2, CAS 1201575-02-1
(3S,4S)-1-Benzyl-4-phenylpyrrolidine-3-carbonitrile
CAS 1201575-02-1C18H18N2
(3R,4R)-1-Benzyl-4-(4-chloro-phenyl)-pyrrolidine-3-carboxylic acid chemical structure, C18H18ClNO2, CAS 1310819-12-5
(3R,4R)-1-Benzyl-4-(4-chloro-phenyl)-pyrrolidine-3-carboxylic acid
CAS 1310819-12-5C18H18ClNO2
(3R,4S)-1-Benzyl-4-(2-methoxyphenyl)pyrrolidine-3-carboxylic acid chemical structure, C19H21NO3
(3R,4S)-1-Benzyl-4-(2-methoxyphenyl)pyrrolidine-3-carboxylic acid
C19H21NO3
Methyl DL-1-benzyl-4-phenylpyrrolidine-3-carboxylate chemical structure, C19H21NO2, CAS 87813-03-4
Methyl DL-1-benzyl-4-phenylpyrrolidine-3-carboxylate
CAS 87813-03-4C19H21NO2
Methyl 1-benzyl-4-phenylpyrrolidine-3-carboxylate chemical structure, C19H21NO2, CAS 438492-33-2
Methyl 1-benzyl-4-phenylpyrrolidine-3-carboxylate
CAS 438492-33-2C19H21NO2
Pyrrolidine, 3-(3-nitrophenyl)-1-(phenylmethyl)- chemical structure, C17H18N2O2, CAS 145104-99-0
Pyrrolidine, 3-(3-nitrophenyl)-1-(phenylmethyl)-
CAS 145104-99-0C17H18N2O2
Methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate chemical structure, C19H20ClNO2, CAS 438492-34-3
Methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate
CAS 438492-34-3C19H20ClNO2