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Murcko scaffold

2-Pyrrolidinone, 1-phenyl-4-piperidinocarbonyl- scaffold

59 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
59
With full pages
6
Scaffold SMILES

O=C(C1CC(=O)N(c2ccccc2)C1)N1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Pyrrolidinone, 1-phenyl-4-piperidinocarbonyl- page
Murcko scaffold O=C(C1CC(=O)N(c2ccccc2)C1)N1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

2-Pyrrolidinone, 1-phenyl-4-piperidinocarbonyl- chemical structure, C16H20N2O2, CAS 39630-00-7
2-Pyrrolidinone, 1-phenyl-4-piperidinocarbonyl-
CAS 39630-00-7C16H20N2O2
1-(4-Chlorophenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C16H19ClN2O2, CAS 39630-15-4
1-(4-Chlorophenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one
CAS 39630-15-4C16H19ClN2O2
1-(4-Hydroxyphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C16H20N2O3, CAS 39630-17-6
1-(4-Hydroxyphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one
CAS 39630-17-6C16H20N2O3
1-(4-Methoxyphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C17H22N2O3, CAS 39630-18-7
1-(4-Methoxyphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one
CAS 39630-18-7C17H22N2O3
1-((5-Oxo-1-(3-(trifluoromethyl)phenyl)-3-pyrrolidinyl)carbonyl)piperidine chemical structure, C17H19F3N2O2, CAS 39630-19-8
1-((5-Oxo-1-(3-(trifluoromethyl)phenyl)-3-pyrrolidinyl)carbonyl)piperidine
CAS 39630-19-8C17H19F3N2O2
1-(4-Methylphenyl)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-one chemical structure, C17H22N2O2, CAS 327992-72-3
1-(4-Methylphenyl)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-one
CAS 327992-72-3C17H22N2O2
Ethyl 1-[1-(4-methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate chemical structure, C20H26N2O4, CAS 825597-65-7
Ethyl 1-[1-(4-methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate
CAS 825597-65-7C20H26N2O4
1-[1-(4-Methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxamide chemical structure, C18H23N3O3, CAS 879594-26-0
1-[1-(4-Methylphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxamide
CAS 879594-26-0C18H23N3O3
Ethyl 1-[1-(4-fluorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate chemical structure, C19H23FN2O4, CAS 878430-31-0
Ethyl 1-[1-(4-fluorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate
CAS 878430-31-0C19H23FN2O4
Ethyl 1-[1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-3-carboxylate chemical structure, C20H26N2O5, CAS 878726-09-1
Ethyl 1-[1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-3-carboxylate
CAS 878726-09-1C20H26N2O5
1-[1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxamide chemical structure, C17H20FN3O3, CAS 892717-97-4
1-[1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxamide
CAS 892717-97-4C17H20FN3O3
1-(4-Methoxyphenyl)-4-(3-methylpiperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C18H24N2O3, CAS 881783-04-6
1-(4-Methoxyphenyl)-4-(3-methylpiperidine-1-carbonyl)pyrrolidin-2-one
CAS 881783-04-6C18H24N2O3
4-(3,5-Dimethylpiperidine-1-carbonyl)-1-(2-methylphenyl)pyrrolidin-2-one chemical structure, C19H26N2O2, CAS 1005288-48-1
4-(3,5-Dimethylpiperidine-1-carbonyl)-1-(2-methylphenyl)pyrrolidin-2-one
CAS 1005288-48-1C19H26N2O2
1-(3-Chloro-4-methylphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C17H21ClN2O2, CAS 887674-95-5
1-(3-Chloro-4-methylphenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one
CAS 887674-95-5C17H21ClN2O2
1-(4-Chlorophenyl)-4-(3-methylpiperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C17H21ClN2O2, CAS 878442-28-5
1-(4-Chlorophenyl)-4-(3-methylpiperidine-1-carbonyl)pyrrolidin-2-one
CAS 878442-28-5C17H21ClN2O2
Ethyl 1-[1-(4-chlorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate chemical structure, C19H23ClN2O4, CAS 878442-30-9
Ethyl 1-[1-(4-chlorophenyl)-5-oxopyrrolidine-3-carbonyl]piperidine-4-carboxylate
CAS 878442-30-9C19H23ClN2O4
1-(4-Chlorophenyl)-4-(4-methylpiperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C17H21ClN2O2, CAS 879600-71-2
1-(4-Chlorophenyl)-4-(4-methylpiperidine-1-carbonyl)pyrrolidin-2-one
CAS 879600-71-2C17H21ClN2O2
1-(4-Fluorophenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one chemical structure, C16H19FN2O2, CAS 878730-90-6
1-(4-Fluorophenyl)-4-(piperidine-1-carbonyl)pyrrolidin-2-one
CAS 878730-90-6C16H19FN2O2
4-[(3,5-Dimethylpiperidin-1-yl)carbonyl]-1-(3-methoxyphenyl)pyrrolidin-2-one chemical structure, C19H26N2O3, CAS 1005147-32-9
4-[(3,5-Dimethylpiperidin-1-yl)carbonyl]-1-(3-methoxyphenyl)pyrrolidin-2-one
CAS 1005147-32-9C19H26N2O3
1-(3,5-Dimethylphenyl)-4-[(3-methylpiperidin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C19H26N2O2, CAS 903018-71-3
1-(3,5-Dimethylphenyl)-4-[(3-methylpiperidin-1-yl)carbonyl]pyrrolidin-2-one
CAS 903018-71-3C19H26N2O2
N-(4-{4-[(2-Ethylpiperidin-1-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide chemical structure, C20H27N3O3, CAS 905180-97-4
N-(4-{4-[(2-Ethylpiperidin-1-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide
CAS 905180-97-4C20H27N3O3
N-(4-{4-[(3,5-Dimethylpiperidin-1-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide chemical structure, C20H27N3O3, CAS 1005056-86-9
N-(4-{4-[(3,5-Dimethylpiperidin-1-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide
CAS 1005056-86-9C20H27N3O3
1-(3-Methoxyphenyl)-4-[(3-methylpiperidin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C18H24N2O3, CAS 950247-36-6
1-(3-Methoxyphenyl)-4-[(3-methylpiperidin-1-yl)carbonyl]pyrrolidin-2-one
CAS 950247-36-6C18H24N2O3
1-[(5-Oxo-1-phenylpyrrolidin-3-yl)carbonyl]piperidine-4-carboxamide chemical structure, C17H21N3O3, CAS 896915-85-8
1-[(5-Oxo-1-phenylpyrrolidin-3-yl)carbonyl]piperidine-4-carboxamide
CAS 896915-85-8C17H21N3O3