Murcko scaffold
Pyrimidine scaffold
19,000 chemicals on CompoundList share this ring system.
- Rings
- 1
- Scaffold atoms
- 6
- Chemicals
- 19,000
- With full pages
- 2,066
Scaffold SMILES
c1cncnc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1,537 to 1,584 of 19,000 chemicals
![2-[[2-(Diethylamino)ethyl]thio]-4,6-pyrimidinediamine chemical structure, C10H19N5S, CAS 2434-45-9](/s/LRMWBHBRDMFUQS-UHFFFAOYSA-N.svg)
2-[[2-(Diethylamino)ethyl]thio]-4,6-pyrimidinediamine
CAS 2434-45-9C10H19N5S
6-Amino-4-methoxy-2-methylthiouracil
CAS 3289-53-0C6H9N3OS
Ethyl 2-(4,6-dichloropyrimidin-2-yl)sulfanylacetate
CAS 50892-12-1C8H8Cl2N2O2S
2-Chloro-N-(5-methoxypyrimidin-2-yl)acetamide
CAS 374684-44-3C7H8ClN3O2
![Acetic acid, [[5-cyano-2-(methylthio)-4-pyrimidinyl]thio]-, ethyl ester chemical structure, C10H11N3O2S2, CAS 113917-99-0](/s/XAZMFMCMOHPSNB-UHFFFAOYSA-N.svg)
Acetic acid, [[5-cyano-2-(methylthio)-4-pyrimidinyl]thio]-, ethyl ester
CAS 113917-99-0C10H11N3O2S2
6-Hydrazinyl-5-nitropyrimidin-4-amine
CAS 3137-54-0C4H6N6O2
2-Methanesulfonyl-5-methoxy-pyrimidine
CAS 1671-09-6C6H8N2O3S
5-Methoxypyrimidine-2-carbohydrazide
CAS 87362-26-3C6H8N4O2
6-Chloro-N,N-dimethyl-2-(methylthio)pyrimidin-4-amine
CAS 161611-29-6C7H10ClN3S
N4-(2,2-diethoxyethyl)-5-nitropyrimidine-4,6-diamine
CAS 450344-72-6C10H17N5O4
4,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile
CAS 33097-13-1C6H3Cl2N3S
![2-({6-Amino-2-[(2-methoxyethyl)amino]-5-nitropyrimidin-4-yl}amino)ethan-1-ol chemical structure, C9H16N6O4, CAS 587012-42-8](/s/DVXFPUBVBSAQEM-UHFFFAOYSA-N.svg)
2-({6-Amino-2-[(2-methoxyethyl)amino]-5-nitropyrimidin-4-yl}amino)ethan-1-ol
CAS 587012-42-8C9H16N6O4
Ethyl 5-pyrimidinecarboxylate
CAS 40929-50-8C7H8N2O2
(6-Hydrazinyl-5-nitropyrimidin-4-yl)hydrazine
CAS 3856-10-8C4H7N7O2
2,4-Dimethoxy-5-nitropyrimidine
CAS 30561-07-0C6H7N3O4
4-Chloro-N-hexadecyl-6-methyl-2-pyrimidinamine
CAS 196813-50-0C21H38ClN3
![2,2-Dimethyl-N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]propanamide chemical structure, C11H15Cl3N4O, CAS 300379-00-4](/s/MZGMARCYCFHLTI-UHFFFAOYSA-N.svg)
2,2-Dimethyl-N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]propanamide
CAS 300379-00-4C11H15Cl3N4O
Methyl 3-(4,6-dimethoxypyrimidin-2-yl)propanoate
CAS 870079-64-4C10H14N2O4
2-(6-Methoxy-5-nitro-4-pyrimidinyl)hydrazinecarboxamide
CAS 7144-17-4C6H8N6O4
![2-[[6-Amino-2-[3-(dimethylamino)propylamino]-5-nitro-4-pyrimidinyl]amino]ethanol chemical structure, C11H21N7O3, CAS 714256-86-7](/s/XLCMMYQQNBEXRV-UHFFFAOYSA-N.svg)
2-[[6-Amino-2-[3-(dimethylamino)propylamino]-5-nitro-4-pyrimidinyl]amino]ethanol
CAS 714256-86-7C11H21N7O3
6-Methoxy-N~4~,N~4~-dimethylpyrimidine-2,4-diamine
CAS 71103-19-0C7H12N4O
![2,2-Dimethyl-N-(2,2,2-trichloro-1-{[6-methyl-2-(methylsulfanyl)pyrimidin-4-yl]oxy}ethyl)propanamide chemical structure, C13H18Cl3N3O2S, CAS 325853-98-3](/s/GISPGJPCEMERDH-UHFFFAOYSA-N.svg)
2,2-Dimethyl-N-(2,2,2-trichloro-1-{[6-methyl-2-(methylsulfanyl)pyrimidin-4-yl]oxy}ethyl)propanamide
CAS 325853-98-3C13H18Cl3N3O2S
2-Methylpyrimidine-4-carboxamide
CAS 88393-97-9C6H7N3O
N4-(3-(diethylamino)propyl)-5-nitropyrimidine-4,6-diamine
CAS 102878-49-9C11H20N6O2
- 5-Nitro-N4,N4-dipropylpyrimidine-2,4-diamine306290-78-8C10H17N5O2
- 6-Methoxy-4-N-methyl-5-nitrosopyrimidine-2,4-diamine89465-57-6C6H9N5O2
- 4-Chloro-6-(1,1-dimethylethyl)pyrimidine3435-24-3C8H11ClN2
- Methyl 2-[[4-methyl-6-(methylthio)-2-pyrimidinyl]thio]acetate347343-11-7C9H12N2O2S2
- 2 suppliers2,4,6-Trichloro-5-nitropyrimidine4359-87-9C4Cl3N3O2
- 6-Methoxy-5-nitropyrimidin-4-amine73318-75-9C5H6N4O3
- 2 suppliers2-Chloro-5-methylpyrimidin-4-amine14394-70-8C5H6ClN3
- Ethyl 2-cyano-3-(pyrimidin-2-ylamino)prop-2-enoate1025689-38-6C10H10N4O2
- 2-Methylpyrimidine-4-carbohydrazide89691-94-1C6H8N4O
- (2-Amino-6-methylpyrimidin-4-ylthio)(diethylamino)methane-1-thione937604-52-9C10H16N4S2
- 2-Pyrimidinamine, N-butyl-10132-28-2C8H13N3
- Ethyl 6-amino-2-chloro-5-nitropyrimidine-4-carboxylate15949-13-0C7H7ClN4O4
- 2-((4-Chloro-6-methyl-pyrimidin-2-yl)-(2-hydroxy-ethyl)-amino)-ethanol22365-21-5C9H14ClN3O2
- N-[4-Amino-5-nitroso-6-(pentyloxy)pyrimidin-2-yl]-N-methylamine64805-21-6C10H17N5O2
- 2-[[2-(2-Hydroxyethylamino)-6-methyl-5-nitropyrimidin-4-yl]amino]ethanol31697-43-5C9H15N5O4
- 5-Methoxypyrimidine-2-carboxamide87362-31-0C6H7N3O2
- 4,6-Dimethoxypyrimidine-2-carboxylic acid128276-50-6C7H8N2O4
- 4,6-Dimethoxypyrimidine-5-carbaldehyde4558-59-2C7H8N2O3
- 3-((6-Amino-5-nitropyrimidin-4-yl)amino)propan-1-ol98335-82-1C7H11N5O3
- 2 suppliersEthyl 4,6-dimethoxypyrimidine-2-carboxylate128276-49-3C9H12N2O4
- (2-Hydrazinyl-5-nitropyrimidin-4-yl)hydrazine3856-09-5C4H7N7O2
- 2-{[(4-Chloro-6-methylpyrimidin-2-yl)amino]methylidene}propanedinitrile946386-68-1C9H6ClN5
- 4-Chloro-6-methoxy-2-methylpyrimidin-5-amine88474-31-1C6H8ClN3O
- 2 suppliers1-(4-Methyl-2-(methylthio)pyrimidin-5-yl)ethanone66373-26-0C8H10N2OS
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cccc[nH]1](/scaffold/UBQKCCHYAOITMY-UHFFFAOYSA-N/structure.svg)
![Scaffold O=c1cc[nH]c(=O)[nH]1](/scaffold/ISAKRJDGNUQOIC-UHFFFAOYSA-N/structure.svg)