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Murcko scaffold

Spiro[3.4]octan-5-one scaffold

8 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
8
With full pages
5
Scaffold SMILES

O=C1CCCC12CCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[3.4]octan-5-one page
Murcko scaffold O=C1CCCC12CCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

Spiro[3.4]octan-5-one chemical structure, C8H12O, CAS 10468-36-7
Spiro[3.4]octan-5-one
CAS 10468-36-7C8H12O
7,7-Dimethylspiro[3.4]octan-8-one chemical structure, C10H16O, CAS 820222-48-8
7,7-Dimethylspiro[3.4]octan-8-one
CAS 820222-48-8C10H16O
6-Methylspiro[3.4]octan-5-one chemical structure, C9H14O, CAS 820222-47-7
6-Methylspiro[3.4]octan-5-one
CAS 820222-47-7C9H14O
tert-Butyl N-({5-oxospiro[3.4]octan-6-yl}methyl)carbamate chemical structure, C14H23NO3, CAS 2241130-86-7
tert-Butyl N-({5-oxospiro[3.4]octan-6-yl}methyl)carbamate
CAS 2241130-86-7C14H23NO3
6-(Aminomethyl)spiro[3.4]octan-5-one chemical structure, C9H15NO, CAS 2387158-38-3
6-(Aminomethyl)spiro[3.4]octan-5-one
CAS 2387158-38-3C9H15NO
2,2-Difluorospiro[3.4]octan-5-one chemical structure, C8H10F2O, CAS 3017211-81-0
2,2-Difluorospiro[3.4]octan-5-one
CAS 3017211-81-0C8H10F2O
2-Methylspiro[3.4]octan-5-one chemical structure, C9H14O, CAS 2923843-59-6
2-Methylspiro[3.4]octan-5-one
CAS 2923843-59-6C9H14O
2-Hydroxyspiro[3.4]octan-5-one chemical structure, C8H12O2, CAS 3026691-00-6
2-Hydroxyspiro[3.4]octan-5-one
CAS 3026691-00-6C8H12O2