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Murcko scaffold

Ring system with 3 rings and 23 atoms

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
17
With full pages
4
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

(2E)-1-(4-Benzylpiperazin-1-yl)-3-(4-chlorophenyl)prop-2-en-1-one chemical structure, C20H21ClN2O, CAS 322763-77-9
(2E)-1-(4-Benzylpiperazin-1-yl)-3-(4-chlorophenyl)prop-2-en-1-one
CAS 322763-77-9C20H21ClN2O
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C23H28N2O4, CAS 307952-93-8
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 307952-93-8C23H28N2O4
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3,4-dichlorophenyl)prop-2-en-1-one chemical structure, C20H20Cl2N2O, CAS 329042-99-1
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3,4-dichlorophenyl)prop-2-en-1-one
CAS 329042-99-1C20H20Cl2N2O
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one chemical structure, C20H21N3O3, CAS 349088-36-4
(E)-1-(4-Benzylpiperazin-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one
CAS 349088-36-4C20H21N3O3
Piperazine, 1-(2-methyl-1-oxo-3-phenyl-2-propenyl)-4-(phenylmethyl)-, (E)- chemical structure, C21H24N2O, CAS 177941-18-3
Piperazine, 1-(2-methyl-1-oxo-3-phenyl-2-propenyl)-4-(phenylmethyl)-, (E)-
CAS 177941-18-3C21H24N2O
2-(4-Benzylpiperazine-1-carbonyl)-3-[4-(difluoromethoxy)phenyl]prop-2-enenitrile chemical structure, C22H21F2N3O2, CAS 326030-96-0
2-(4-Benzylpiperazine-1-carbonyl)-3-[4-(difluoromethoxy)phenyl]prop-2-enenitrile
CAS 326030-96-0C22H21F2N3O2
(Z)-2-(4-Benzylpiperazine-1-carbonyl)-3-phenylprop-2-enenitrile chemical structure, C21H21N3O, CAS 734544-27-5
(Z)-2-(4-Benzylpiperazine-1-carbonyl)-3-phenylprop-2-enenitrile
CAS 734544-27-5C21H21N3O
(E)-1-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C20H21FN2O, CAS 1684444-35-6
(E)-1-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-3-phenylprop-2-en-1-one
CAS 1684444-35-6C20H21FN2O
(E)-1-[4-[(3-Fluorophenyl)methyl]piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C20H21FN2O, CAS 1684444-27-6
(E)-1-[4-[(3-Fluorophenyl)methyl]piperazin-1-yl]-3-phenylprop-2-en-1-one
CAS 1684444-27-6C20H21FN2O
(E)-1-(4-Benzylpiperazino)-3-[4-(3-fluoropropoxy)phenyl]-2-propen-1-one chemical structure, C23H27FN2O2, CAS 477871-10-6
(E)-1-(4-Benzylpiperazino)-3-[4-(3-fluoropropoxy)phenyl]-2-propen-1-one
CAS 477871-10-6C23H27FN2O2
1-(4-Benzylpiperazino)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one chemical structure, C21H21F3N2O2, CAS 882082-67-9
1-(4-Benzylpiperazino)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one
CAS 882082-67-9C21H21F3N2O2
N-[5-Chloro-2-[(1E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-3-oxo-1-propen-1-yl]phenyl]-acetamide chemical structure, C23H25ClFN3O2, CAS 685534-25-2
N-[5-Chloro-2-[(1E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-3-oxo-1-propen-1-yl]phenyl]-acetamide
CAS 685534-25-2C23H25ClFN3O2
N-[(E)-1-(4-Benzyl-piperazine-1-carbonyl)-2-(2-chloro-phenyl)-vinyl]-acetamide chemical structure, C22H24ClN3O2, CAS 917747-62-7
N-[(E)-1-(4-Benzyl-piperazine-1-carbonyl)-2-(2-chloro-phenyl)-vinyl]-acetamide
CAS 917747-62-7C22H24ClN3O2
1-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]-3-(2-nitrophenyl)prop-2-en-1-one chemical structure, C20H20ClN3O3, CAS 960356-21-2
1-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]-3-(2-nitrophenyl)prop-2-en-1-one
CAS 960356-21-2C20H20ClN3O3
N-[3-(4-Benzylpiperazin-1-yl)-1-(2-chlorophenyl)-3-oxoprop-1-en-2-yl]acetamide chemical structure, C22H24ClN3O2
N-[3-(4-Benzylpiperazin-1-yl)-1-(2-chlorophenyl)-3-oxoprop-1-en-2-yl]acetamide
C22H24ClN3O2
(E)-3-(4-Bromophenyl)-1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one chemical structure, C20H20BrClN2O, CAS 1597489-14-9
(E)-3-(4-Bromophenyl)-1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one
CAS 1597489-14-9C20H20BrClN2O
1-Sinapoyl-4-(3'-chloro)benzylpiperazine chemical structure, C22H25ClN2O4, CAS 1239956-42-3
1-Sinapoyl-4-(3'-chloro)benzylpiperazine
CAS 1239956-42-3C22H25ClN2O4