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Murcko scaffold

7-Oxa-2,5-diazaspiro[3.4]octan-6-one scaffold

17 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
17
With full pages
4
Scaffold SMILES

O=C1NC2(CNC2)CO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 7-Oxa-2,5-diazaspiro[3.4]octan-6-one page
Murcko scaffold O=C1NC2(CNC2)CO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

7-Oxa-2,5-diazaspiro[3.4]octan-6-one chemical structure, C5H8N2O2, CAS 1780174-72-2
7-Oxa-2,5-diazaspiro[3.4]octan-6-one
CAS 1780174-72-2C5H8N2O2
5-Methyl-7-oxa-2,5-diazaspiro[3.4]octan-6-one chemical structure, C6H10N2O2, CAS 1784606-78-5
5-Methyl-7-oxa-2,5-diazaspiro[3.4]octan-6-one
CAS 1784606-78-5C6H10N2O2
tert-Butyl 6-oxo-7-oxa-2,5-diazaspiro[3.4]octane-2-carboxylate chemical structure, C10H16N2O4, CAS 2135702-43-9
tert-Butyl 6-oxo-7-oxa-2,5-diazaspiro[3.4]octane-2-carboxylate
CAS 2135702-43-9C10H16N2O4
7-Oxa-2,5-diazaspiro[3.4]octan-6-one, trifluoroacetic acid chemical structure, C7H9F3N2O4, CAS 2229318-51-6
7-Oxa-2,5-diazaspiro[3.4]octan-6-one, trifluoroacetic acid
CAS 2229318-51-6C7H9F3N2O4
5-Methyl-7-oxa-2,5-diazaspiro[3.4]octan-6-one hydrochloride chemical structure, C6H11ClN2O2, CAS 2825011-64-9
5-Methyl-7-oxa-2,5-diazaspiro[3.4]octan-6-one hydrochloride
CAS 2825011-64-9C6H11ClN2O2
Prop-2-en-1-yl 6-oxo-7-oxa-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C9H12N2O4, CAS 2680777-73-3
Prop-2-en-1-yl 6-oxo-7-oxa-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2680777-73-3C9H12N2O4
2-{6-Oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid chemical structure, C7H10N2O4, CAS 2901083-41-6
2-{6-Oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid
CAS 2901083-41-6C7H10N2O4
Methyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate hydrochloride chemical structure, C8H13ClN2O4, CAS 2901095-17-6
Methyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate hydrochloride
CAS 2901095-17-6C8H13ClN2O4
Methyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate chemical structure, C8H12N2O4, CAS 2901095-16-5
Methyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate
CAS 2901095-16-5C8H12N2O4
2-{6-Oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid hydrochloride chemical structure, C7H11ClN2O4, CAS 2901083-42-7
2-{6-Oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid hydrochloride
CAS 2901083-42-7C7H11ClN2O4
2-{2-[(tert-Butoxy)carbonyl]-6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid chemical structure, C12H18N2O6, CAS 2901095-45-0
2-{2-[(tert-Butoxy)carbonyl]-6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid
CAS 2901095-45-0C12H18N2O6
tert-Butyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate, trifluoroacetic acid chemical structure, C13H19F3N2O6, CAS 2901097-01-4
tert-Butyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate, trifluoroacetic acid
CAS 2901097-01-4C13H19F3N2O6
tert-Butyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate chemical structure, C11H18N2O4, CAS 2901097-00-3
tert-Butyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate
CAS 2901097-00-3C11H18N2O4
2-{2-Acetyl-6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid chemical structure, C9H12N2O5, CAS 2920130-14-7
2-{2-Acetyl-6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid
CAS 2920130-14-7C9H12N2O5
2-{6-Oxo-2-[(prop-2-en-1-yloxy)carbonyl]-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid chemical structure, C11H14N2O6, CAS 2920153-24-6
2-{6-Oxo-2-[(prop-2-en-1-yloxy)carbonyl]-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetic acid
CAS 2920153-24-6C11H14N2O6
2-[6-Oxo-2-(2,2,2-trifluoroacetyl)-7-oxa-2,5-diazaspiro[3.4]octan-5-yl]acetic acid chemical structure, C9H9F3N2O5, CAS 2920162-55-4
2-[6-Oxo-2-(2,2,2-trifluoroacetyl)-7-oxa-2,5-diazaspiro[3.4]octan-5-yl]acetic acid
CAS 2920162-55-4C9H9F3N2O5
Ethyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate chemical structure, C9H14N2O4, CAS 2920146-09-2
Ethyl 2-{6-oxo-7-oxa-2,5-diazaspiro[3.4]octan-5-yl}acetate
CAS 2920146-09-2C9H14N2O4