CompoundList
Sign in
Murcko scaffold

2-(4-Benzylpiperazin-1-yl)pyrimidine scaffold

142 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
142
With full pages
8
Scaffold SMILES

c1ccc(CN2CCN(c3ncccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(4-Benzylpiperazin-1-yl)pyrimidine page
Murcko scaffold c1ccc(CN2CCN(c3ncccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 142 chemicals

p-Cresol, 2-methoxy-alpha-(4-(2-pyrimidinyl)-1-piperazinyl)-, hydrochloride, hydrate (2:4:1) chemical structure, C16H22Cl2N4O2, CAS 3601-83-0
p-Cresol, 2-methoxy-alpha-(4-(2-pyrimidinyl)-1-piperazinyl)-, hydrochloride, hydrate (2:4:1)
CAS 3601-83-0C16H22Cl2N4O2
2-Methoxy-4-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)phenol chemical structure, C16H20N4O2, CAS 19971-72-3
2-Methoxy-4-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)phenol
CAS 19971-72-3C16H20N4O2
4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)-1,2-benzenediol chemical structure, C15H18N4O2, CAS 50602-50-1
4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)-1,2-benzenediol
CAS 50602-50-1C15H18N4O2
2-(4-Veratryl-1-piperazinyl)pyrimidine chemical structure, C17H22N4O2, CAS 3601-85-2
2-(4-Veratryl-1-piperazinyl)pyrimidine
CAS 3601-85-2C17H22N4O2
Pyrimidine, 2-(4-(2,4-dimethoxybenzyl)-1-piperazinyl)-, dihydrochloride chemical structure, C17H24Cl2N4O2, CAS 3829-69-4
Pyrimidine, 2-(4-(2,4-dimethoxybenzyl)-1-piperazinyl)-, dihydrochloride
CAS 3829-69-4C17H24Cl2N4O2
Pyrimidine, 2-(4-(2,3,4-trimethoxybenzyl)-1-piperazinyl)- chemical structure, C18H24N4O3, CAS 3884-60-4
Pyrimidine, 2-(4-(2,3,4-trimethoxybenzyl)-1-piperazinyl)-
CAS 3884-60-4C18H24N4O3
Pyrocatechol, 4-((4-(2-pyrimidinyl)-1-piperazinyl)methyl)-, hydrochloride, hydrate (2:4:1) chemical structure, C15H20Cl2N4O2, CAS 19971-73-4
Pyrocatechol, 4-((4-(2-pyrimidinyl)-1-piperazinyl)methyl)-, hydrochloride, hydrate (2:4:1)
CAS 19971-73-4C15H20Cl2N4O2
2-[4-[[3-(Trifluoromethyl)phenyl]methyl]piperazin-1-yl]pyrimidine chemical structure, C16H17F3N4, CAS 414873-98-6
2-[4-[[3-(Trifluoromethyl)phenyl]methyl]piperazin-1-yl]pyrimidine
CAS 414873-98-6C16H17F3N4
2-[4-[(3-Bromophenyl)methyl]-1-piperazinyl]pyrimidine chemical structure, C15H17BrN4, CAS 204634-66-2
2-[4-[(3-Bromophenyl)methyl]-1-piperazinyl]pyrimidine
CAS 204634-66-2C15H17BrN4
2-[4-(2,4-Dichlorobenzyl)piperazin-1-yl]pyrimidine chemical structure, C15H16Cl2N4, CAS 414882-62-5
2-[4-(2,4-Dichlorobenzyl)piperazin-1-yl]pyrimidine
CAS 414882-62-5C15H16Cl2N4
2-[4-(4-Fluorobenzyl)-1-piperazinyl]pyrimidine chemical structure, C15H17FN4, CAS 414886-02-5
2-[4-(4-Fluorobenzyl)-1-piperazinyl]pyrimidine
CAS 414886-02-5C15H17FN4
2-[4-[(2-Fluorophenyl)methyl]piperazin-1-yl]pyrimidine chemical structure, C15H17FN4, CAS 414886-22-9
2-[4-[(2-Fluorophenyl)methyl]piperazin-1-yl]pyrimidine
CAS 414886-22-9C15H17FN4
N,N-Diethyl-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]aniline chemical structure, C19H27N5, CAS 415932-46-6
N,N-Diethyl-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]aniline
CAS 415932-46-6C19H27N5
2-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]pyrimidine chemical structure, C15H17ClN4, CAS 414885-23-7
2-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]pyrimidine
CAS 414885-23-7C15H17ClN4
2-[4-[(3,4-Dichlorophenyl)methyl]piperazin-1-yl]pyrimidine chemical structure, C15H16Cl2N4, CAS 331855-83-5
2-[4-[(3,4-Dichlorophenyl)methyl]piperazin-1-yl]pyrimidine
CAS 331855-83-5C15H16Cl2N4
2-(4-Benzylpiperazin-1-yl)pyrimidine chemical structure, C15H18N4, CAS 115495-96-0
2-(4-Benzylpiperazin-1-yl)pyrimidine
CAS 115495-96-0C15H18N4
2-(4-Benzylpiperazin-1-yl)-4,6-dimethoxypyrimidine chemical structure, C17H22N4O2, CAS 153469-02-4
2-(4-Benzylpiperazin-1-yl)-4,6-dimethoxypyrimidine
CAS 153469-02-4C17H22N4O2
2-((4-(Pyrimidin-2-yl)piperazin-1-yl)methyl)benzonitrile chemical structure, C16H17N5, CAS 923832-53-5
2-((4-(Pyrimidin-2-yl)piperazin-1-yl)methyl)benzonitrile
CAS 923832-53-5C16H17N5
2-(4-Benzylpiperazin-1-yl)-4,6-dimethylpyrimidine chemical structure, C17H22N4, CAS 88268-22-8
2-(4-Benzylpiperazin-1-yl)-4,6-dimethylpyrimidine
CAS 88268-22-8C17H22N4
2-{4-[(3,4-Dimethoxyphenyl)methyl]-2-methylpiperazin-1-yl}pyrimidine chemical structure, C18H24N4O2, CAS 97993-28-7
2-{4-[(3,4-Dimethoxyphenyl)methyl]-2-methylpiperazin-1-yl}pyrimidine
CAS 97993-28-7C18H24N4O2
Ethyl 2-(4-benzylpiperazino)-4-chloromethylpyrimidine-5-carboxylate chemical structure, C19H23ClN4O2, CAS 104966-06-5
Ethyl 2-(4-benzylpiperazino)-4-chloromethylpyrimidine-5-carboxylate
CAS 104966-06-5C19H23ClN4O2
4-Amino-2-(4-benzyl-1-piperazinyl)-5-pyrimidinecarbonitrile chemical structure, C16H18N6, CAS 1019017-12-9
4-Amino-2-(4-benzyl-1-piperazinyl)-5-pyrimidinecarbonitrile
CAS 1019017-12-9C16H18N6
N,N-Dimethyl-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}benzene-1-sulfonamide chemical structure, C17H23N5O2S, CAS 923900-87-2
N,N-Dimethyl-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}benzene-1-sulfonamide
CAS 923900-87-2C17H23N5O2S
2-{4-[(2-Chlorophenyl)methyl]piperazin-1-yl}-4-methoxypyrimidine chemical structure, C16H19ClN4O, CAS 1387834-47-0
2-{4-[(2-Chlorophenyl)methyl]piperazin-1-yl}-4-methoxypyrimidine
CAS 1387834-47-0C16H19ClN4O