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Murcko scaffold

1-(1-Benzylpiperidin-4-yl)piperazine scaffold

59 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
59
With full pages
4
Scaffold SMILES

c1ccc(CN2CCC(N3CCNCC3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1-Benzylpiperidin-4-yl)piperazine page
Murcko scaffold c1ccc(CN2CCC(N3CCNCC3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

1-[4-(1-Benzylpiperidin-4-yl)piperazin-1-yl]-3-methylbutan-1-one chemical structure, C21H33N3O, CAS 494862-62-3
1-[4-(1-Benzylpiperidin-4-yl)piperazin-1-yl]-3-methylbutan-1-one
CAS 494862-62-3C21H33N3O
2-[4-[1-[(2-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C19H31N3O2, CAS 432008-03-2
2-[4-[1-[(2-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 432008-03-2C19H31N3O2
2-[4-[1-[(3-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C19H31N3O2, CAS 432011-02-4
2-[4-[1-[(3-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 432011-02-4C19H31N3O2
2-{4-[1-(4-Chlorobenzyl)piperidin-4-yl]piperazin-1-yl}ethanol chemical structure, C18H28ClN3O, CAS 431939-55-8
2-{4-[1-(4-Chlorobenzyl)piperidin-4-yl]piperazin-1-yl}ethanol
CAS 431939-55-8C18H28ClN3O
2-[4-[1-[(4-Methylsulfanylphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C19H31N3OS, CAS 431924-54-8
2-[4-[1-[(4-Methylsulfanylphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431924-54-8C19H31N3OS
2-{4-[1-(2-Methylbenzyl)-4-piperidinyl]-1-piperazinyl}ethanol chemical structure, C19H31N3O, CAS 432011-38-6
2-{4-[1-(2-Methylbenzyl)-4-piperidinyl]-1-piperazinyl}ethanol
CAS 432011-38-6C19H31N3O
1-(1-Benzylpiperidin-4-yl)-4-methylpiperazine chemical structure, C17H27N3, CAS 205059-34-3
1-(1-Benzylpiperidin-4-yl)-4-methylpiperazine
CAS 205059-34-3C17H27N3
1-[1-[(2-Methoxyphenyl)methyl]piperidin-4-yl]-4-methylpiperazine chemical structure, C18H29N3O, CAS 418808-68-1
1-[1-[(2-Methoxyphenyl)methyl]piperidin-4-yl]-4-methylpiperazine
CAS 418808-68-1C18H29N3O
2-[4-[1-[(2-Fluorophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C18H28FN3O, CAS 431998-93-5
2-[4-[1-[(2-Fluorophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431998-93-5C18H28FN3O
2-[4-[1-[(4-Ethylphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C20H33N3O, CAS 432004-80-3
2-[4-[1-[(4-Ethylphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 432004-80-3C20H33N3O
2-[4-[1-[(4-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C19H31N3O2, CAS 432010-45-2
2-[4-[1-[(4-Methoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 432010-45-2C19H31N3O2
2-[4-[1-[(4-Nitrophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C18H28N4O3, CAS 489462-06-8
2-[4-[1-[(4-Nitrophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 489462-06-8C18H28N4O3
1-Ethyl-4-[1-(2-nitrobenzyl)piperidin-4-yl]piperazine chemical structure, C18H28N4O2, CAS 792927-18-5
1-Ethyl-4-[1-(2-nitrobenzyl)piperidin-4-yl]piperazine
CAS 792927-18-5C18H28N4O2
2-{4-[1-(3-Methylbenzyl)piperidin-4-yl]piperazin-1-yl}ethanol chemical structure, C19H31N3O, CAS 496773-63-8
2-{4-[1-(3-Methylbenzyl)piperidin-4-yl]piperazin-1-yl}ethanol
CAS 496773-63-8C19H31N3O
2-{4-[1-(3-Chlorobenzyl)piperidin-4-yl]piperazin-1-yl}ethanol chemical structure, C18H28ClN3O, CAS 489425-79-8
2-{4-[1-(3-Chlorobenzyl)piperidin-4-yl]piperazin-1-yl}ethanol
CAS 489425-79-8C18H28ClN3O
1-(1-Benzylpiperidin-4-yl)piperazine chemical structure, C16H25N3, CAS 180532-65-4
1-(1-Benzylpiperidin-4-yl)piperazine
CAS 180532-65-4C16H25N3
1-(1-Benzylpiperidin-4-yl)-4-propan-2-ylpiperazine chemical structure, C19H31N3, CAS 425389-73-7
1-(1-Benzylpiperidin-4-yl)-4-propan-2-ylpiperazine
CAS 425389-73-7C19H31N3
1-(1-Benzylpiperidin-4-yl)-4-methylsulfonylpiperazine chemical structure, C17H27N3O2S, CAS 6043-22-7
1-(1-Benzylpiperidin-4-yl)-4-methylsulfonylpiperazine
CAS 6043-22-7C17H27N3O2S
2-[4-[1-[(2,3,4-Trimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C21H35N3O4, CAS 431929-70-3
2-[4-[1-[(2,3,4-Trimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431929-70-3C21H35N3O4
2-(4-{1-[2-(Trifluoromethyl)benzyl]piperidin-4-yl}piperazin-1-yl)ethanol chemical structure, C19H28F3N3O, CAS 431930-98-2
2-(4-{1-[2-(Trifluoromethyl)benzyl]piperidin-4-yl}piperazin-1-yl)ethanol
CAS 431930-98-2C19H28F3N3O
2-[4-[1-[(2,5-Dimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C20H33N3O3, CAS 431906-60-4
2-[4-[1-[(2,5-Dimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431906-60-4C20H33N3O3
2-[4-[1-[(4-Bromophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C18H28BrN3O, CAS 431907-27-6
2-[4-[1-[(4-Bromophenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431907-27-6C18H28BrN3O
2-[4-[1-[(2,4-Dimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol chemical structure, C20H33N3O3, CAS 431983-41-4
2-[4-[1-[(2,4-Dimethoxyphenyl)methyl]piperidin-4-yl]piperazin-1-yl]ethanol
CAS 431983-41-4C20H33N3O3
2-{4-[1-(2-Ethoxybenzyl)piperidin-4-yl]piperazin-1-yl}ethanol chemical structure, C20H33N3O2, CAS 792928-29-1
2-{4-[1-(2-Ethoxybenzyl)piperidin-4-yl]piperazin-1-yl}ethanol
CAS 792928-29-1C20H33N3O2