Murcko scaffold
Ring system with 2 rings and 16 atoms
176 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 176
- With full pages
- 18
Scaffold SMILES
O=C(COc1ccccc1)Nc1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 176 chemicals
![4,5-Dimethyl-2-{[(4-methylphenoxy)acetyl]amino}thiophene-3-carboxamide chemical structure, C16H18N2O3S, CAS 444148-29-2](/s/LVZIWVBBYSSGRR-UHFFFAOYSA-N.svg)
4,5-Dimethyl-2-{[(4-methylphenoxy)acetyl]amino}thiophene-3-carboxamide
CAS 444148-29-2C16H18N2O3S
![2-{[(4-Chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C15H15ClN2O3S, CAS 444148-43-0](/s/GCGPKFMXEPOKEH-UHFFFAOYSA-N.svg)
2-{[(4-Chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 444148-43-0C15H15ClN2O3S
4,5-Dimethyl-2-(2-(m-tolyloxy)acetamido)thiophene-3-carboxamide
CAS 433322-67-9C16H18N2O3S
4,5-Dimethyl-2-(2-phenoxyacetamido)thiophene-3-carboxamide
CAS 315675-44-6C15H16N2O3S
![2-{[(4-Methoxyphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C16H18N2O4S, CAS 511517-84-3](/s/QYNWXZQHLRYJIK-UHFFFAOYSA-N.svg)
2-{[(4-Methoxyphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 511517-84-3C16H18N2O4S
![2-{[(2-Isopropylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C18H22N2O3S, CAS 650620-51-2](/s/KMGVBLOOYGYXNL-UHFFFAOYSA-N.svg)
2-{[(2-Isopropylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 650620-51-2C18H22N2O3S
![2-{[(2,6-Dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C17H20N2O3S, CAS 651018-08-5](/s/CRXWHCUJQRUZJH-UHFFFAOYSA-N.svg)
2-{[(2,6-Dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 651018-08-5C17H20N2O3S
![Methyl 2-{[(4-ethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C18H21NO4S, CAS 445231-87-8](/s/PBWQCMBWOPIQPF-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-ethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 445231-87-8C18H21NO4S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-phenoxyacetamide
CAS 354141-11-0C15H14N2O2S
![Methyl 5-ethyl-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C17H19NO4S, CAS 354141-63-2](/s/OXVOOSCTZDYHNL-UHFFFAOYSA-N.svg)
Methyl 5-ethyl-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 354141-63-2C17H19NO4S
![2-[[2-(4-Ethylphenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C17H20N2O3S, CAS 352701-57-6](/s/YLMKTRBGGSMHDY-UHFFFAOYSA-N.svg)
2-[[2-(4-Ethylphenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide
CAS 352701-57-6C17H20N2O3S
![2-{[(2-Chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C15H15ClN2O3S, CAS 642939-69-3](/s/MPOGFBKDMVTOGW-UHFFFAOYSA-N.svg)
2-{[(2-Chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 642939-69-3C15H15ClN2O3S
![2-{[(4-Isopropylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C18H22N2O3S, CAS 651018-76-7](/s/DWXSGCUVIGDINF-UHFFFAOYSA-N.svg)
2-{[(4-Isopropylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 651018-76-7C18H22N2O3S
![Ethyl 2-{[(2-isopropyl-5-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C21H27NO4S, CAS 302803-46-9](/s/YONGGHGDZFTBGO-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-isopropyl-5-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 302803-46-9C21H27NO4S
![Ethyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C18H20BrNO4S, CAS 302803-54-9](/s/NHGOFNHGQDFEKK-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 302803-54-9C18H20BrNO4S
2,4-Diethyl 3-methyl-5-(2-phenoxyacetamido)thiophene-2,4-dicarboxylate
CAS 300828-46-0C19H21NO6S
![Diethyl 5-{[(2-bromo-4-methylphenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate chemical structure, C20H22BrNO6S, CAS 301693-51-6](/s/MBLMBLLTEUHDRE-UHFFFAOYSA-N.svg)
Diethyl 5-{[(2-bromo-4-methylphenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate
CAS 301693-51-6C20H22BrNO6S
![Diethyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate chemical structure, C19H19Cl2NO6S, CAS 67836-07-1](/s/IKHHAOWRBDJSKZ-UHFFFAOYSA-N.svg)
Diethyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate
CAS 67836-07-1C19H19Cl2NO6S
Diethyl 3-methyl-5-(((2-methylphenoxy)acetyl)amino)-2,4-thiophenedicarboxylate
CAS 6049-16-7C20H23NO6S
![Ethyl 5-carbamoyl-2-{[(4-chlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C17H17ClN2O5S, CAS 544459-02-1](/s/LYLJJUQMNHPHFD-UHFFFAOYSA-N.svg)
Ethyl 5-carbamoyl-2-{[(4-chlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate
CAS 544459-02-1C17H17ClN2O5S
![Ethyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-5-[(dimethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C19H20Cl2N2O5S, CAS 547703-99-1](/s/SQCCFYOZOIGZLO-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-5-[(dimethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 547703-99-1C19H20Cl2N2O5S
![Methyl 2-{[(4-chloro-2-methylphenoxy)acetyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C21H25ClN2O5S, CAS 335406-10-5](/s/QXOZPHPXGHRSJB-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-chloro-2-methylphenoxy)acetyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 335406-10-5C21H25ClN2O5S
![Isopropyl 5-acetyl-2-{[(2-chlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C19H20ClNO5S, CAS 444908-65-0](/s/PPRFLOZIEPYTMJ-UHFFFAOYSA-N.svg)
Isopropyl 5-acetyl-2-{[(2-chlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate
CAS 444908-65-0C19H20ClNO5S
![Ethyl 5-carbamoyl-4-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C17H18N2O5S, CAS 355002-18-5](/s/ABTFBKZNIKOOSD-UHFFFAOYSA-N.svg)
Ethyl 5-carbamoyl-4-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 355002-18-5C17H18N2O5S
- Methyl 2-[[2-(4-chlorophenoxy)acetyl]amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate544424-25-1C20H23ClN2O5S
- Diethyl 5-{[(2-fluorophenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate438471-47-7C19H20FNO6S
- 2-{[(4-Bromo-3-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide444068-61-5C16H17BrN2O3S
- 4,5-Dimethyl-2-[[2-(5-methyl-2-propan-2-ylphenoxy)acetyl]amino]thiophene-3-carboxamide443895-09-8C19H24N2O3S
- 2-{[(4-tert-Butylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide496032-77-0C19H24N2O3S
- 2-{[(2-Bromo-4-chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide658046-37-8C15H14BrClN2O3S
- 2-{[(4-Chloro-3,5-dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide650614-42-9C17H19ClN2O3S
- Ethyl 5-carbamoyl-4-methyl-2-{[(3-methylphenoxy)acetyl]amino}thiophene-3-carboxylate445013-14-9C18H20N2O5S
- Isopropyl 4-ethyl-5-methyl-2-{[(4-methylphenoxy)acetyl]amino}-3-thiophenecarboxylate445014-61-9C20H25NO4S
- Diethyl 5-{[(2,4-dimethylphenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate303033-38-7C21H25NO6S
- Ethyl 2-[2-(2,4-dichlorophenoxy)acetamido]-5-ethylthiophene-3-carboxylate67836-05-9C17H17Cl2NO4S
- Ethyl 5-ethyl-2-{[(2-isopropyl-5-methylphenoxy)acetyl]amino}-3-thiophenecarboxylate380643-88-9C21H27NO4S
- Ethyl 2-{[(4-isopropylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate302803-49-2C20H25NO4S
- Ethyl 2-{[(2,5-dichlorophenoxy)acetyl]amino}-4,5-dimethylthiophene-3-carboxylate302803-52-7C17H17Cl2NO4S
- Ethyl 5-(diethylcarbamoyl)-4-methyl-2-[2-(2-methylphenoxy)acetamido]thiophene-3-carboxylate347352-28-7C22H28N2O5S
- Ethyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate347352-00-5C21H24Cl2N2O5S
- Ethyl 2-[[2-(2,4-dichlorophenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate67836-08-2C17H17Cl2NO4S
- Diethyl 5-{[(4-isopropyl-3-methylphenoxy)acetyl]amino}-3-methylthiophene-2,4-dicarboxylate347366-61-4C23H29NO6S
- Ethyl 4-methyl-2-[(phenoxyacetyl)amino]-5-propyl-3-thiophenecarboxylate342397-15-3C19H23NO4S
- Diethyl 5-{[(2-isopropylphenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate301681-97-0C22H27NO6S
- Ethyl 5-acetyl-2-{[(2-tert-butyl-5-methylphenoxy)acetyl]amino}-4-methyl-3-thiophenecarboxylate304890-96-8C23H29NO5S
- Ethyl 5-acetyl-2-{[(2-tert-butylphenoxy)acetyl]amino}-4-methyl-3-thiophenecarboxylate304892-91-9C22H27NO5S
- Ethyl 5-acetyl-2-{[(2-isopropylphenoxy)acetyl]amino}-4-methyl-3-thiophenecarboxylate301681-98-1C21H25NO5S
- Ethyl 5-acetyl-2-[2-(2-bromo-4-methylphenoxy)acetamido]-4-methylthiophene-3-carboxylate301693-53-8C19H20BrNO5S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals