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Murcko scaffold

Ring system with 2 rings and 16 atoms

176 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
176
With full pages
18
Scaffold SMILES

O=C(COc1ccccc1)Nc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 176 chemicals

Diethyl 5-{[(3-bromophenoxy)acetyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C19H20BrNO6S, CAS 329223-89-4
Diethyl 5-{[(3-bromophenoxy)acetyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 329223-89-4C19H20BrNO6S
2-{[(2,4-Dichlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C15H14Cl2N2O3S, CAS 329221-73-0
2-{[(2,4-Dichlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide
CAS 329221-73-0C15H14Cl2N2O3S
2-[[2-(4-Chloro-2-methylphenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H17ClN2O3S, CAS 424810-50-4
2-[[2-(4-Chloro-2-methylphenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide
CAS 424810-50-4C16H17ClN2O3S
Ethyl 5-acetyl-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 300828-08-4
Ethyl 5-acetyl-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate
CAS 300828-08-4C18H19NO5S
Diethyl 3-methyl-5-({[5-methyl-2-(propan-2-yl)phenoxy]acetyl}amino)thiophene-2,4-dicarboxylate chemical structure, C23H29NO6S, CAS 5570-68-3
Diethyl 3-methyl-5-({[5-methyl-2-(propan-2-yl)phenoxy]acetyl}amino)thiophene-2,4-dicarboxylate
CAS 5570-68-3C23H29NO6S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C20H22Cl2N2O5S, CAS 505096-56-0
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 505096-56-0C20H22Cl2N2O5S
Ethyl 5-acetyl-2-[2-(4-chlorophenoxy)acetamido]-4-methylthiophene-3-carboxylate chemical structure, C18H18ClNO5S, CAS 300828-09-5
Ethyl 5-acetyl-2-[2-(4-chlorophenoxy)acetamido]-4-methylthiophene-3-carboxylate
CAS 300828-09-5C18H18ClNO5S
Diethyl 5-[[2-(4-chloro-2-methyl-phenoxy)acetyl]amino]-3-methyl-thiophene-2,4-dicarboxylate chemical structure, C20H22ClNO6S, CAS 6147-96-2
Diethyl 5-[[2-(4-chloro-2-methyl-phenoxy)acetyl]amino]-3-methyl-thiophene-2,4-dicarboxylate
CAS 6147-96-2C20H22ClNO6S
Ethyl 4,5-dimethyl-2-{[(2,3,6-trimethylphenoxy)acetyl]amino}thiophene-3-carboxylate chemical structure, C20H25NO4S, CAS 433305-34-1
Ethyl 4,5-dimethyl-2-{[(2,3,6-trimethylphenoxy)acetyl]amino}thiophene-3-carboxylate
CAS 433305-34-1C20H25NO4S
Ethyl 4-carbamoyl-5-[[2-(4-chloro-2-methylphenoxy)acetyl]amino]-3-methylthiophene-2-carboxylate chemical structure, C18H19ClN2O5S, CAS 313703-39-8
Ethyl 4-carbamoyl-5-[[2-(4-chloro-2-methylphenoxy)acetyl]amino]-3-methylthiophene-2-carboxylate
CAS 313703-39-8C18H19ClN2O5S
Isopropyl 4-ethyl-5-methyl-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate chemical structure, C19H23NO4S, CAS 303133-73-5
Isopropyl 4-ethyl-5-methyl-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate
CAS 303133-73-5C19H23NO4S
Isopropyl 2-{[(4-chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C18H20ClNO4S, CAS 353471-18-8
Isopropyl 2-{[(4-chlorophenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 353471-18-8C18H20ClNO4S
Dimethyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate chemical structure, C17H15Cl2NO6S, CAS 551909-41-2
Dimethyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methyl-2,4-thiophenedicarboxylate
CAS 551909-41-2C17H15Cl2NO6S
4-Cyano-5-[[2-(2,4-dimethylphenoxy)acetyl]amino]-N,N-diethyl-3-methylthiophene-2-carboxamide chemical structure, C21H25N3O3S, CAS 438615-93-1
4-Cyano-5-[[2-(2,4-dimethylphenoxy)acetyl]amino]-N,N-diethyl-3-methylthiophene-2-carboxamide
CAS 438615-93-1C21H25N3O3S
Ethyl 2-[[2-(2-methylphenoxy)acetyl]amino]-4-(2-methylpropyl)thiophene-3-carboxylate chemical structure, C20H25NO4S, CAS 312939-66-5
Ethyl 2-[[2-(2-methylphenoxy)acetyl]amino]-4-(2-methylpropyl)thiophene-3-carboxylate
CAS 312939-66-5C20H25NO4S
4,5-Dimethyl-2-{[(2,4,6-trichlorophenoxy)acetyl]amino}-3-thiophenecarboxamide chemical structure, C15H13Cl3N2O3S, CAS 445003-81-6
4,5-Dimethyl-2-{[(2,4,6-trichlorophenoxy)acetyl]amino}-3-thiophenecarboxamide
CAS 445003-81-6C15H13Cl3N2O3S
5-{[(4-Chloro-2-methylphenoxy)acetyl]amino}-4-cyano-N,N,3-trimethylthiophene-2-carboxamide chemical structure, C18H18ClN3O3S, CAS 445014-42-6
5-{[(4-Chloro-2-methylphenoxy)acetyl]amino}-4-cyano-N,N,3-trimethylthiophene-2-carboxamide
CAS 445014-42-6C18H18ClN3O3S
Methyl 2-{[(2,4-difluorophenoxy)acetyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H15F2NO4S, CAS 403715-28-6
Methyl 2-{[(2,4-difluorophenoxy)acetyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 403715-28-6C16H15F2NO4S
2-(4-Bromophenoxy)-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)acetamide chemical structure, C16H15BrN2O2S, CAS 775301-22-9
2-(4-Bromophenoxy)-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)acetamide
CAS 775301-22-9C16H15BrN2O2S
2-[(2-Phenoxyacetyl)amino]thiophene-3-carboxamide chemical structure, C13H12N2O3S, CAS 717867-34-0
2-[(2-Phenoxyacetyl)amino]thiophene-3-carboxamide
CAS 717867-34-0C13H12N2O3S
Methyl 5-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C15H15NO4S, CAS 717867-54-4
Methyl 5-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 717867-54-4C15H15NO4S
4-Ethyl 2-methyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H17Cl2NO6S, CAS 433941-64-1
4-Ethyl 2-methyl 5-{[(2,4-dichlorophenoxy)acetyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 433941-64-1C18H17Cl2NO6S
Ethyl 5-acetyl-2-{[(4-fluorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C18H18FNO5S, CAS 403714-76-1
Ethyl 5-acetyl-2-{[(4-fluorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate
CAS 403714-76-1C18H18FNO5S
Ethyl 5-acetyl-2-[2-(4-chloro-3-methylphenoxy)acetamido]-4-methylthiophene-3-carboxylate chemical structure, C19H20ClNO5S, CAS 692263-66-4
Ethyl 5-acetyl-2-[2-(4-chloro-3-methylphenoxy)acetamido]-4-methylthiophene-3-carboxylate
CAS 692263-66-4C19H20ClNO5S