Murcko scaffold
Ring system with 2 rings and 16 atoms
176 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 176
- With full pages
- 18
Scaffold SMILES
O=C(COc1ccccc1)Nc1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 97 to 144 of 176 chemicals
2-(2-(2,4-Dichlorophenoxy)acetamido)thiophene-3-carboxamide
CAS 791134-00-4C13H10Cl2N2O3S
![Ethyl 5-acetyl-2-{[(2,5-dichlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C18H17Cl2NO5S, CAS 301304-98-3](/s/NNVFXOKUKWHHQB-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-2-{[(2,5-dichlorophenoxy)acetyl]amino}-4-methylthiophene-3-carboxylate
CAS 301304-98-3C18H17Cl2NO5S
![Ethyl 2-{[(4-chloro-3-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C18H20ClNO4S, CAS 302803-48-1](/s/KXQFFPGMIBZZTO-UHFFFAOYSA-N.svg)
Ethyl 2-{[(4-chloro-3-methylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 302803-48-1C18H20ClNO4S
![Ethyl 2-{[(3,4-dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C19H23NO4S, CAS 302803-50-5](/s/AEROLFHPJITDRL-UHFFFAOYSA-N.svg)
Ethyl 2-{[(3,4-dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 302803-50-5C19H23NO4S
![Diethyl 5-{[2-(4-methoxyphenoxy)propanoyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C21H25NO7S, CAS 302807-00-7](/s/LQTBAEQQGUJPTD-UHFFFAOYSA-N.svg)
Diethyl 5-{[2-(4-methoxyphenoxy)propanoyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 302807-00-7C21H25NO7S
![Ethyl 5-acetyl-2-{[2-(4-methoxyphenoxy)propanoyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C20H23NO6S, CAS 302807-01-8](/s/DUNJOZVEXWRXDU-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-2-{[2-(4-methoxyphenoxy)propanoyl]amino}-4-methylthiophene-3-carboxylate
CAS 302807-01-8C20H23NO6S
![Ethyl 2-{[2-(4-methoxyphenoxy)propanoyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C19H23NO5S, CAS 302807-05-2](/s/ZVSHDDOREBUPHK-UHFFFAOYSA-N.svg)
Ethyl 2-{[2-(4-methoxyphenoxy)propanoyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 302807-05-2C19H23NO5S
Ethyl 4,5-dimethyl-2-(2-phenoxybutanoylamino)thiophene-3-carboxylate
CAS 354140-60-6C19H23NO4S
AK-968/37005290
CAS 5557-89-1C17H18N2O2S
![Ethyl 5-carbamoyl-2-[2-(2,4-dichlorophenoxy)propanoylamino]-4-methylthiophene-3-carboxylate chemical structure, C18H18Cl2N2O5S, CAS 419557-99-6](/s/UBLSUGNDNBMZRJ-UHFFFAOYSA-N.svg)
Ethyl 5-carbamoyl-2-[2-(2,4-dichlorophenoxy)propanoylamino]-4-methylthiophene-3-carboxylate
CAS 419557-99-6C18H18Cl2N2O5S
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-(2-phenoxybutanoylamino)thiophene-3-carboxylate
CAS 5700-35-6C23H30N2O5S
![Ethyl 2-{[2-(4-chloro-2-methylphenoxy)propanoyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C23H29ClN2O5S, CAS 353786-97-7](/s/XHDUBCBMBTVWRI-UHFFFAOYSA-N.svg)
Ethyl 2-{[2-(4-chloro-2-methylphenoxy)propanoyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 353786-97-7C23H29ClN2O5S
Ethyl 4-carbamoyl-3-methyl-5-(2-phenoxybutanoylamino)thiophene-2-carboxylate
CAS 420094-89-9C19H22N2O5S
Dipropan-2-yl 3-methyl-5-(2-phenoxybutanoylamino)thiophene-2,4-dicarboxylate
CAS 420094-99-1C23H29NO6S
![Methyl 2-{[2-(4-chloro-2-methylphenoxy)propanoyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C22H27ClN2O5S, CAS 424812-77-1](/s/OADPGLFJCWEDAO-UHFFFAOYSA-N.svg)
Methyl 2-{[2-(4-chloro-2-methylphenoxy)propanoyl]amino}-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 424812-77-1C22H27ClN2O5S
![Diethyl 5-{[2-(2-methoxyphenoxy)propanoyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C21H25NO7S, CAS 431068-22-3](/s/WNVOKXHHAGBLKP-UHFFFAOYSA-N.svg)
Diethyl 5-{[2-(2-methoxyphenoxy)propanoyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 431068-22-3C21H25NO7S
![Ethyl 5-acetyl-2-[2-(2-methoxyphenoxy)propanamido]-4-methylthiophene-3-carboxylate chemical structure, C20H23NO6S, CAS 842958-77-4](/s/VAHLZDJSBIWWPX-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-2-[2-(2-methoxyphenoxy)propanamido]-4-methylthiophene-3-carboxylate
CAS 842958-77-4C20H23NO6S
![2-[2-(2,4-Dichlorophenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H16Cl2N2O3S, CAS 353773-17-8](/s/XMNHUPQLARIEGV-UHFFFAOYSA-N.svg)
2-[2-(2,4-Dichlorophenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxamide
CAS 353773-17-8C16H16Cl2N2O3S
Diethyl 3-methyl-5-(2-phenoxybutanoylamino)thiophene-2,4-dicarboxylate
CAS 544434-20-0C21H25NO6S
![2-[2-(4-Chloro-2-methylphenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C17H19ClN2O3S, CAS 353479-53-5](/s/AGOYZZCYRKWLDE-UHFFFAOYSA-N.svg)
2-[2-(4-Chloro-2-methylphenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxamide
CAS 353479-53-5C17H19ClN2O3S
Ethyl 5-acetyl-4-methyl-2-(2-phenoxybutanoylamino)thiophene-3-carboxylate
CAS 543714-90-5C20H23NO5S
![Dimethyl 3-methyl-5-[(2-phenoxybutanoyl)amino]thiophene-2,4-dicarboxylate chemical structure, C19H21NO6S, CAS 362482-79-9](/s/FWQYARGDLSXYHB-UHFFFAOYSA-N.svg)
Dimethyl 3-methyl-5-[(2-phenoxybutanoyl)amino]thiophene-2,4-dicarboxylate
CAS 362482-79-9C19H21NO6S
![2-[2-(4-Chloro-2-methylphenoxy)propanoylamino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C18H21ClN2O3S, CAS 438617-25-5](/s/LGUNQJNPAMOXGT-UHFFFAOYSA-N.svg)
2-[2-(4-Chloro-2-methylphenoxy)propanoylamino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 438617-25-5C18H21ClN2O3S
![Methyl 5-acetyl-2-[2-(4-fluorophenoxy)propanamido]-4-methylthiophene-3-carboxylate chemical structure, C18H18FNO5S, CAS 617679-47-7](/s/UBPRHGZINNEQCW-UHFFFAOYSA-N.svg)
Methyl 5-acetyl-2-[2-(4-fluorophenoxy)propanamido]-4-methylthiophene-3-carboxylate
CAS 617679-47-7C18H18FNO5S
- Methyl 5-acetyl-2-[2-(4-chloro-3,5-dimethylphenoxy)propanoylamino]-4-methylthiophene-3-carboxylate692279-43-9C20H22ClNO5S
- Ethyl 4,5-dimethyl-2-(2-phenoxypropanoylamino)thiophene-3-carboxylate663218-15-3C18H21NO4S
- 2-{[(2-sec-Butylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide650573-02-7C19H24N2O3S
- 4-Ethyl 2-methyl 5-{[2-(2,4-dichlorophenoxy)propanoyl]amino}-3-methylthiophene-2,4-dicarboxylate701254-47-9C19H19Cl2NO6S
- 2-{[(4-Bromo-2,6-dimethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide650588-69-5C17H19BrN2O3S
- 2-[2-(2-Chloro-5-methylphenoxy)butanoylamino]thiophene-3-carboxamide895949-83-4C16H17ClN2O3S
- 2-[2-(4-Methyl-2-nitrophenoxy)butanoylamino]-5-propan-2-ylthiophene-3-carboxamide895951-39-0C19H23N3O5S
- 4,5-Dimethyl-2-{[2-(4-methylphenoxy)propanoyl]amino}-3-thiophenecarboxamide817633-40-2C17H20N2O3S
- 4,5-Dimethyl-2-{[2-(2-methylphenoxy)propanoyl]amino}-3-thiophenecarboxamide821013-12-1C17H20N2O3S
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(3,5-dimethylphenoxy)acetamide842117-72-0C17H18N2O2S
- Propan-2-yl 2-[[2-(2-chlorophenoxy)acetyl]amino]-4,5-dimethylthiophene-3-carboxylate445004-89-7C18H20ClNO4S
- Methyl 2-[2-(4-chloro-2-methylphenoxy)propanoylamino]-4-ethyl-5-methylthiophene-3-carboxylate420091-45-8C19H22ClNO4S
- 2-(3-Chlorophenoxy)-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)propanamide5702-56-7C17H17ClN2O2S
- Ethyl 3-methyl-5-(2-phenoxyacetamido)-4-thiocyanatothiophene-2-carboxylate681162-24-3C17H16N2O4S2
- 2-(4-Chlorophenoxy)-N-(3-cyano-4,5-dimethylthiophen-2-yl)acetamide545339-74-0C15H13ClN2O2S
- Diisopropyl 5-{[2-(4-fluorophenoxy)propanoyl]amino}-3-methyl-2,4-thiophenedicarboxylate438615-02-2C22H26FNO6S
- 4,5-Dimethyl-2-[[2-(4-methyl-2-nitrophenoxy)acetyl]amino]thiophene-3-carboxamide352702-83-1C16H17N3O5S
- 4-Ethyl-5-methyl-2-{[(4-methylphenoxy)acetyl]amino}-3-thiophenecarboxamide445014-44-8C17H20N2O3S
- Methyl 5-acetyl-2-[2-(2-fluorophenoxy)propanamido]-4-methylthiophene-3-carboxylate617679-46-6C18H18FNO5S
- 4-Cyano-N,N,3-trimethyl-5-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-2-carboxamide514818-03-2C17H16N4O5S
- Methyl 2-[2-(4-chloro-2-methylphenoxy)propanoylamino]-5-methylthiophene-3-carboxylate445007-03-4C17H18ClNO4S
- Ethyl (4,5-dimethyl-2-(((2-methylphenoxy)acetyl)amino)-3-thienyl)acetate303092-52-6C19H23NO4S
- Ethyl 2-[2-(4-fluorophenoxy)acetamido]-4,5-dimethylthiophene-3-carboxylate331454-87-6C17H18FNO4S
- 2-[2-(Acetylamino)phenoxy]-N-(3-cyano-2-thienyl)acetamide338777-55-2C15H13N3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals