Murcko scaffold
Ring system with 2 rings and 16 atoms
176 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 176
- With full pages
- 18
Scaffold SMILES
O=C(COc1ccccc1)Nc1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 145 to 176 of 176 chemicals
N-(3-Cyano-4-ethyl-5-methyl-2-thienyl)-2-(4-fluorophenoxy)acetamide
CAS 514800-10-3C16H15FN2O2S
![Ethyl 2-[[2-(3-methylphenoxy)acetyl]amino]-5-propan-2-ylthiophene-3-carboxylate chemical structure, C19H23NO4S, CAS 445000-62-4](/s/GVTWDEGHNWCOGA-UHFFFAOYSA-N.svg)
Ethyl 2-[[2-(3-methylphenoxy)acetyl]amino]-5-propan-2-ylthiophene-3-carboxylate
CAS 445000-62-4C19H23NO4S
N-Methyl-2-(2-phenoxyacetamido)thiophene-3-carboxamide
CAS 864974-78-7C14H14N2O3S
![Ethyl 2-[2-(2,5-dichlorophenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C18H19Cl2NO4S, CAS 515872-63-6](/s/BYRZNTHTDMSLNQ-UHFFFAOYSA-N.svg)
Ethyl 2-[2-(2,5-dichlorophenoxy)propanoylamino]-4,5-dimethylthiophene-3-carboxylate
CAS 515872-63-6C18H19Cl2NO4S
![Methyl 5-ethyl-2-[[2-(4-methylphenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C17H19NO4S, CAS 445021-48-7](/s/ZBIGVZXCJIXNPJ-UHFFFAOYSA-N.svg)
Methyl 5-ethyl-2-[[2-(4-methylphenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 445021-48-7C17H19NO4S
![Ethyl 2-[2-(4-fluorophenoxy)propanamido]-4,5-dimethylthiophene-3-carboxylate chemical structure, C18H20FNO4S, CAS 352690-66-5](/s/XAZQQKGRTFUCAB-UHFFFAOYSA-N.svg)
Ethyl 2-[2-(4-fluorophenoxy)propanamido]-4,5-dimethylthiophene-3-carboxylate
CAS 352690-66-5C18H20FNO4S
![Methyl 5-carbamoyl-4-methyl-2-{[(4-methylphenoxy)acetyl]amino}thiophene-3-carboxylate chemical structure, C17H18N2O5S, CAS 444940-19-6](/s/PXIKEBTZPLOSIS-UHFFFAOYSA-N.svg)
Methyl 5-carbamoyl-4-methyl-2-{[(4-methylphenoxy)acetyl]amino}thiophene-3-carboxylate
CAS 444940-19-6C17H18N2O5S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(2,4-difluorophenoxy)acetamide
CAS 514801-44-6C15H12F2N2O2S
![Ethyl 5-acetyl-2-{[2-(2-fluorophenoxy)propanoyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C19H20FNO5S, CAS 617679-27-3](/s/LUMAQQUZTPCNQV-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-2-{[2-(2-fluorophenoxy)propanoyl]amino}-4-methylthiophene-3-carboxylate
CAS 617679-27-3C19H20FNO5S
![Ethyl 2-{[2-(2-chloro-5-methylphenoxy)propanoyl]amino}-5-methylthiophene-3-carboxylate chemical structure, C18H20ClNO4S, CAS 588694-47-7](/s/KAJBMEXZZFJBGM-UHFFFAOYSA-N.svg)
Ethyl 2-{[2-(2-chloro-5-methylphenoxy)propanoyl]amino}-5-methylthiophene-3-carboxylate
CAS 588694-47-7C18H20ClNO4S
![Ethyl 2-{[2-(2-chloro-5-methylphenoxy)-2-methylpropanoyl]amino}-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C22H27ClN2O5S, CAS 588694-79-5](/s/HMEVQVVIVVKOKS-UHFFFAOYSA-N.svg)
Ethyl 2-{[2-(2-chloro-5-methylphenoxy)-2-methylpropanoyl]amino}-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 588694-79-5C22H27ClN2O5S
![Methyl 4-ethyl-5-methyl-2-[[2-(2-methylphenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C18H21NO4S, CAS 492428-57-6](/s/GOQOUIAKNIWQME-UHFFFAOYSA-N.svg)
Methyl 4-ethyl-5-methyl-2-[[2-(2-methylphenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 492428-57-6C18H21NO4S
![Methyl 2-{[(3-methoxyphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C17H19NO5S, CAS 353766-76-4](/s/PMEAUIWOLCWKHC-UHFFFAOYSA-N.svg)
Methyl 2-{[(3-methoxyphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 353766-76-4C17H19NO5S
![Methyl 4-carbamoyl-5-{[(2,4-difluorophenoxy)acetyl]amino}-3-methylthiophene-2-carboxylate chemical structure, C16H14F2N2O5S, CAS 738608-99-6](/s/ARBYXWHBALIVTA-UHFFFAOYSA-N.svg)
Methyl 4-carbamoyl-5-{[(2,4-difluorophenoxy)acetyl]amino}-3-methylthiophene-2-carboxylate
CAS 738608-99-6C16H14F2N2O5S
![4-Cyano-5-{[(2,4-dichlorophenoxy)acetyl]amino}-N,N,3-trimethylthiophene-2-carboxamide chemical structure, C17H15Cl2N3O3S, CAS 444940-33-4](/s/BMCXPNRDTQIFLG-UHFFFAOYSA-N.svg)
4-Cyano-5-{[(2,4-dichlorophenoxy)acetyl]amino}-N,N,3-trimethylthiophene-2-carboxamide
CAS 444940-33-4C17H15Cl2N3O3S
![Isopropyl 4-ethyl-5-methyl-2-{[(2-methylphenoxy)acetyl]amino}-3-thiophenecarboxylate chemical structure, C20H25NO4S, CAS 445003-32-7](/s/OQAYBVFFVANIJC-UHFFFAOYSA-N.svg)
Isopropyl 4-ethyl-5-methyl-2-{[(2-methylphenoxy)acetyl]amino}-3-thiophenecarboxylate
CAS 445003-32-7C20H25NO4S
![Propan-2-yl 5-carbamoyl-4-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C18H20N2O5S, CAS 444999-34-2](/s/HSLQCZDCRHXWFQ-UHFFFAOYSA-N.svg)
Propan-2-yl 5-carbamoyl-4-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 444999-34-2C18H20N2O5S
4,5-Dimethyl-2-(2-phenoxybutanoylamino)thiophene-3-carboxamide
CAS 313382-40-0C17H20N2O3S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(4-methyl-2-nitrophenoxy)acetamide
CAS 895953-15-8C16H15N3O4S
![Methyl 2-[2-(4-chlorophenoxy)acetamido]thiophene-3-carboxylate chemical structure, C14H12ClNO4S, CAS 896680-33-4](/s/KUTPPXULZWLKQC-UHFFFAOYSA-N.svg)
Methyl 2-[2-(4-chlorophenoxy)acetamido]thiophene-3-carboxylate
CAS 896680-33-4C14H12ClNO4S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)thiophene-3-carboxylate
CAS 888412-97-3C14H11Cl2NO4S
2-(4-Chlorophenoxy)-N-(3-cyanothiophen-2-yl)acetamide
CAS 941997-94-0C13H9ClN2O2S
N-(3-Cyanothiophen-2-yl)-2-phenoxyacetamide
CAS 920464-11-5C13H10N2O2S
N,4,5-trimethyl-2-(2-phenoxyacetamido)thiophene-3-carboxamide
CAS 896300-42-8C16H18N2O3S
- 2-(2-(4-Chlorophenoxy)acetamido)-N,4,5-trimethylthiophene-3-carboxamide896302-20-8C16H17ClN2O3S
- Methyl (4,5-dimethyl-2-(2-phenoxyacetamido)thiophene-3-carbonyl)carbamate896309-90-3C17H18N2O5S
- Methyl (2-(2-(4-chlorophenoxy)acetamido)-4,5-dimethylthiophene-3-carbonyl)carbamate896311-49-2C17H17ClN2O5S
- Methyl 2-{2-[4-(hydroxymethyl)-2-methoxyphenoxy]acetamido}-4,5-dimethylthiophene-3-carboxylate869703-09-3C18H21NO6S
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(4-methoxyphenoxy)acetamide900763-82-8C16H16N2O3S
- Methyl 2-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-5-propylthiophene-3-carboxylate524733-31-1C19H22ClNO4S
- 3-Methyl-5-(2-phenoxyacetamido)thiophene-2-carboxylic acid1016535-37-7C14H13NO4S
- 2-{[(3-Ethylphenoxy)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxamide1158615-55-4C17H20N2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals