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Murcko scaffold

Ring system with 3 rings and 18 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
28
With full pages
3
Scaffold SMILES

c1ccc(N2CCN(Cc3cccs3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(Cc3cccs3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

1-[(5-Nitrothiophen-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C16H16F3N3O2S, CAS 331855-69-7
1-[(5-Nitrothiophen-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 331855-69-7C16H16F3N3O2S
1-[(5-Bromothiophen-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C16H16BrF3N2S, CAS 376604-30-7
1-[(5-Bromothiophen-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 376604-30-7C16H16BrF3N2S
1-[(4-Bromothiophen-2-yl)methyl]-4-(3-chlorophenyl)piperazine chemical structure, C15H16BrClN2S, CAS 5262-21-5
1-[(4-Bromothiophen-2-yl)methyl]-4-(3-chlorophenyl)piperazine
CAS 5262-21-5C15H16BrClN2S
N-[1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-thiophen-2-ylpropan-2-yl]methanesulfonamide chemical structure, C18H24FN3O2S2, CAS 847381-32-2
N-[1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-thiophen-2-ylpropan-2-yl]methanesulfonamide
CAS 847381-32-2C18H24FN3O2S2
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)ethanesulfonamide chemical structure, C20H29N3O3S2, CAS 847381-41-3
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)ethanesulfonamide
CAS 847381-41-3C20H29N3O3S2
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)methanesulfonamide chemical structure, C19H27N3O3S2, CAS 847381-40-2
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)methanesulfonamide
CAS 847381-40-2C19H27N3O3S2
N-{1-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}-2,2-dimethylpropanamide chemical structure, C22H30FN3OS, CAS 887205-94-9
N-{1-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}-2,2-dimethylpropanamide
CAS 887205-94-9C22H30FN3OS
N-(1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)propionamide chemical structure, C20H26FN3OS, CAS 887206-03-3
N-(1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)propionamide
CAS 887206-03-3C20H26FN3OS
N-(1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide chemical structure, C21H28FN3OS, CAS 887206-11-3
N-(1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide
CAS 887206-11-3C21H28FN3OS
N-{1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}-3-methylbutanamide chemical structure, C22H30FN3OS, CAS 887206-20-4
N-{1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}-3-methylbutanamide
CAS 887206-20-4C22H30FN3OS
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)propionamide chemical structure, C21H29N3O2S, CAS 887206-31-7
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)propionamide
CAS 887206-31-7C21H29N3O2S
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)butyramide chemical structure, C22H31N3O2S, CAS 887206-34-0
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)butyramide
CAS 887206-34-0C22H31N3O2S
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide chemical structure, C22H31N3O2S, CAS 887206-38-4
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide
CAS 887206-38-4C22H31N3O2S
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)pivalamide chemical structure, C23H33N3O2S, CAS 887206-43-1
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)pivalamide
CAS 887206-43-1C23H33N3O2S
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)-3-methylbutanamide chemical structure, C23H33N3O2S, CAS 887206-46-4
N-(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)-3-methylbutanamide
CAS 887206-46-4C23H33N3O2S
N-(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)acetamide chemical structure, C20H27N3O2S, CAS 887206-62-4
N-(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)acetamide
CAS 887206-62-4C20H27N3O2S
N-{1-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}propanamide chemical structure, C21H29N3O2S, CAS 887206-65-7
N-{1-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(thiophen-2-yl)propan-2-yl}propanamide
CAS 887206-65-7C21H29N3O2S
N-(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide chemical structure, C22H31N3O2S, CAS 887206-69-1
N-(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)isobutyramide
CAS 887206-69-1C22H31N3O2S
4-[4-(Thiophen-2-ylmethyl)piperazin-1-yl]aniline chemical structure, C15H19N3S, CAS 611399-58-7
4-[4-(Thiophen-2-ylmethyl)piperazin-1-yl]aniline
CAS 611399-58-7C15H19N3S
2-[4-(2-Thienylmethyl)-1-piperazinyl]benzenemethanamine chemical structure, C16H21N3S, CAS 937599-81-0
2-[4-(2-Thienylmethyl)-1-piperazinyl]benzenemethanamine
CAS 937599-81-0C16H21N3S
N-[2-(Diethylamino)ethyl]-N'-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-methyl-2-thien-2-ylethyl}ethanediamide chemical structure, C26H39N5O3S, CAS 847195-73-7
N-[2-(Diethylamino)ethyl]-N'-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-methyl-2-thien-2-ylethyl}ethanediamide
CAS 847195-73-7C26H39N5O3S
1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-amine chemical structure, C17H22FN3S, CAS 941868-15-1
1-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-amine
CAS 941868-15-1C17H22FN3S
1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-amine chemical structure, C18H25N3OS, CAS 941868-17-3
1-(4-(4-Methoxyphenyl)piperazin-1-yl)-1-(thiophen-2-yl)propan-2-amine
CAS 941868-17-3C18H25N3OS
Ethyl 2-oxo-2-((1-(4-phenylpiperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)amino)acetate chemical structure, C21H27N3O3S, CAS 1207048-63-2
Ethyl 2-oxo-2-((1-(4-phenylpiperazin-1-yl)-1-(thiophen-2-yl)propan-2-yl)amino)acetate
CAS 1207048-63-2C21H27N3O3S