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Murcko scaffold

Ring system with 3 rings and 22 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
10
With full pages
6
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

1-[3-(4-Fluorophenyl)acryloyl]-4-(2-pyridinyl)piperazine chemical structure, C18H18FN3O, CAS 1164505-95-6
1-[3-(4-Fluorophenyl)acryloyl]-4-(2-pyridinyl)piperazine
CAS 1164505-95-6C18H18FN3O
3-(3,4-Dichlorophenyl)-1-(4-(2-pyridyl)piperazinyl)prop-2-EN-1-one chemical structure, C18H17Cl2N3O, CAS 497060-99-8
3-(3,4-Dichlorophenyl)-1-(4-(2-pyridyl)piperazinyl)prop-2-EN-1-one
CAS 497060-99-8C18H17Cl2N3O
1-(2-Pyridinyl)-4-(3-(2,3,4-trimethoxyphenyl)acryloyl)piperazine chemical structure, C21H25N3O4, CAS 647031-56-9
1-(2-Pyridinyl)-4-(3-(2,3,4-trimethoxyphenyl)acryloyl)piperazine
CAS 647031-56-9C21H25N3O4
1-[4-(6-Chloropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C18H18ClN3O, CAS 339107-40-3
1-[4-(6-Chloropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-en-1-one
CAS 339107-40-3C18H18ClN3O
1-Cinnamoyl-4-(2-pyridinyl)piperazine chemical structure, C18H19N3O, CAS 1164538-01-5
1-Cinnamoyl-4-(2-pyridinyl)piperazine
CAS 1164538-01-5C18H19N3O
3-Phenyl-1-{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}prop-2-en-1-one chemical structure, C19H18F3N3O, CAS 260367-88-2
3-Phenyl-1-{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}prop-2-en-1-one
CAS 260367-88-2C19H18F3N3O
3-(3-Bromophenyl)-1-[4-(2-pyridinyl)piperazino]-2-propen-1-one chemical structure, C18H18BrN3O, CAS 647031-71-8
3-(3-Bromophenyl)-1-[4-(2-pyridinyl)piperazino]-2-propen-1-one
CAS 647031-71-8C18H18BrN3O
(E)-1-[4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C19H17ClF3N3O, CAS 1025152-62-8
(E)-1-[4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-3-phenylprop-2-en-1-one
CAS 1025152-62-8C19H17ClF3N3O
3-(4-Propoxyphenyl)-1-[4-(2-pyridinyl)piperazino]-2-propen-1-one chemical structure, C21H25N3O2, CAS 329779-67-1
3-(4-Propoxyphenyl)-1-[4-(2-pyridinyl)piperazino]-2-propen-1-one
CAS 329779-67-1C21H25N3O2
Piperazine, 1-(2-pyridyl)-4-(3,4,5-trimethoxycinnamoyl)- chemical structure, C21H25N3O4, CAS 22662-32-4
Piperazine, 1-(2-pyridyl)-4-(3,4,5-trimethoxycinnamoyl)-
CAS 22662-32-4C21H25N3O4