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Murcko scaffold

(4-Cyclohexylpiperazin-1-yl)-phenylmethanone scaffold

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
24
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C2CCCCC2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Cyclohexylpiperazin-1-yl)-phenylmethanone page
Murcko scaffold O=C(c1ccccc1)N1CCN(C2CCCCC2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Ketone, 4-cyclohexylpiperazinyl 3,4,5-trimethoxyphenyl chemical structure, C20H30N2O4, CAS 17837-64-8
Ketone, 4-cyclohexylpiperazinyl 3,4,5-trimethoxyphenyl
CAS 17837-64-8C20H30N2O4
(4-Methoxyphenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C19H28N2O2, CAS 461423-53-0
(4-Methoxyphenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone
CAS 461423-53-0C19H28N2O2
(4-Fluorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C18H25FN2O, CAS 441743-70-0
(4-Fluorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone
CAS 441743-70-0C18H25FN2O
(4-Cyclohexylpiperazin-1-yl)(4-fluorophenyl)methanone chemical structure, C17H23FN2O, CAS 356075-87-1
(4-Cyclohexylpiperazin-1-yl)(4-fluorophenyl)methanone
CAS 356075-87-1C17H23FN2O
(4-Cyclohexylpiperazin-1-yl)-(2,3-dimethoxyphenyl)methanone chemical structure, C19H28N2O3, CAS 441743-26-6
(4-Cyclohexylpiperazin-1-yl)-(2,3-dimethoxyphenyl)methanone
CAS 441743-26-6C19H28N2O3
(2-Fluorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C18H25FN2O, CAS 423745-12-4
(2-Fluorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone
CAS 423745-12-4C18H25FN2O
[4-(4-Methylcyclohexyl)piperazin-1-yl](4-nitrophenyl)methanone chemical structure, C18H25N3O3, CAS 423745-61-3
[4-(4-Methylcyclohexyl)piperazin-1-yl](4-nitrophenyl)methanone
CAS 423745-61-3C18H25N3O3
1-Cyclohexyl-4-(3-methoxybenzoyl)piperazine chemical structure, C18H26N2O2, CAS 441743-54-0
1-Cyclohexyl-4-(3-methoxybenzoyl)piperazine
CAS 441743-54-0C18H26N2O2
[4-(4-Methylcyclohexyl)piperazin-1-yl]-phenylmethanone chemical structure, C18H26N2O, CAS 425397-04-2
[4-(4-Methylcyclohexyl)piperazin-1-yl]-phenylmethanone
CAS 425397-04-2C18H26N2O
(4-Cyclohexylpiperazin-1-yl)-phenylmethanone chemical structure, C17H24N2O, CAS 107785-15-9
(4-Cyclohexylpiperazin-1-yl)-phenylmethanone
CAS 107785-15-9C17H24N2O
(3,5-Dimethoxyphenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C20H30N2O3, CAS 462601-87-2
(3,5-Dimethoxyphenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone
CAS 462601-87-2C20H30N2O3
1-Cyclohexyl-4-(3,5-dimethoxybenzoyl)piperazine chemical structure, C19H28N2O3, CAS 423748-10-1
1-Cyclohexyl-4-(3,5-dimethoxybenzoyl)piperazine
CAS 423748-10-1C19H28N2O3
(3-Chlorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C18H25ClN2O, CAS 425391-30-6
(3-Chlorophenyl)-[4-(4-methylcyclohexyl)piperazin-1-yl]methanone
CAS 425391-30-6C18H25ClN2O
1-(4-Methylcyclohexyl)-4-(3,4,5-trimethoxybenzoyl)piperazine chemical structure, C21H32N2O4, CAS 425395-53-5
1-(4-Methylcyclohexyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS 425395-53-5C21H32N2O4
1-Cyclohexyl-4-(4-nitrobenzoyl)piperazine chemical structure, C17H23N3O3, CAS 625411-48-5
1-Cyclohexyl-4-(4-nitrobenzoyl)piperazine
CAS 625411-48-5C17H23N3O3
(4-Aminophenyl)(4-cyclohexylpiperazino)methanone chemical structure, C17H25N3O, CAS 885949-70-2
(4-Aminophenyl)(4-cyclohexylpiperazino)methanone
CAS 885949-70-2C17H25N3O
(4-Methoxyphenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C19H28N2O2, CAS 423744-94-9
(4-Methoxyphenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone
CAS 423744-94-9C19H28N2O2
(3-Chlorophenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C18H25ClN2O, CAS 356075-82-6
(3-Chlorophenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone
CAS 356075-82-6C18H25ClN2O
(4-Fluorophenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone chemical structure, C18H25FN2O, CAS 425391-92-0
(4-Fluorophenyl)-[4-(3-methylcyclohexyl)piperazin-1-yl]methanone
CAS 425391-92-0C18H25FN2O
1-(3-Methylcyclohexyl)-4-(3,4,5-trimethoxybenzoyl)piperazine chemical structure, C21H32N2O4, CAS 510718-90-8
1-(3-Methylcyclohexyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS 510718-90-8C21H32N2O4
[4-(3-Methylcyclohexyl)piperazin-1-yl](4-nitrophenyl)methanone chemical structure, C18H25N3O3, CAS 425397-47-3
[4-(3-Methylcyclohexyl)piperazin-1-yl](4-nitrophenyl)methanone
CAS 425397-47-3C18H25N3O3
1-(3,5-Dimethoxybenzoyl)-4-(3-methylcyclohexyl)piperazine chemical structure, C20H30N2O3, CAS 332899-12-4
1-(3,5-Dimethoxybenzoyl)-4-(3-methylcyclohexyl)piperazine
CAS 332899-12-4C20H30N2O3
N-[4-(4-Cyclohexylpiperazine-1-carbonyl)phenyl]prop-2-enamide chemical structure, C20H27N3O2, CAS 2270918-64-2
N-[4-(4-Cyclohexylpiperazine-1-carbonyl)phenyl]prop-2-enamide
CAS 2270918-64-2C20H27N3O2
(3-Aminophenyl)(4-cyclohexylpiperazin-1-yl)methanone chemical structure, C17H25N3O, CAS 2777781-26-5
(3-Aminophenyl)(4-cyclohexylpiperazin-1-yl)methanone
CAS 2777781-26-5C17H25N3O