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Murcko scaffold

Biphenyl-4-yl(piperazin-1-yl)methanone scaffold

16 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 16
With full pages: 4

Scaffold SMILES

O=C(c1ccc(-c2ccccc2)cc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the Biphenyl-4-yl(piperazin-1-yl)methanone page

Murcko scaffold O=C(c1ccc(-c2ccccc2)cc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Ethyl 4-[(4-phenylphenyl)carbonyl]piperazinecarboxylate chemical structure, C20H22N2O3, CAS 349407-19-8

Ethyl 4-[(4-phenylphenyl)carbonyl]piperazinecarboxylate

CAS 349407-19-8C₂₀H₂₂N₂O₃

Biphenyl-4-yl[4-(methylsulfonyl)piperazin-1-yl]methanone chemical structure, C18H20N2O3S, CAS 333756-65-3

Biphenyl-4-yl[4-(methylsulfonyl)piperazin-1-yl]methanone

CAS 333756-65-3C₁₈H₂₀N₂O₃S

Biphenyl-4-yl-(4-methyl-piperazin-1-yl)-methanone chemical structure, C18H20N2O, CAS 5254-05-7

Biphenyl-4-yl-(4-methyl-piperazin-1-yl)-methanone

CAS 5254-05-7C₁₈H₂₀N₂O

Biphenyl-4-yl(4-ethylpiperazin-1-yl)methanone chemical structure, C19H22N2O, CAS 326610-13-3

Biphenyl-4-yl(4-ethylpiperazin-1-yl)methanone

CAS 326610-13-3C₁₉H₂₂N₂O

1-(4-Biphenylylcarbonyl)-4-(ethylsulfonyl)piperazine chemical structure, C19H22N2O3S, CAS 428504-63-6

1-(4-Biphenylylcarbonyl)-4-(ethylsulfonyl)piperazine

CAS 428504-63-6C₁₉H₂₂N₂O₃S

Biphenyl-4-yl[4-(butan-2-yl)piperazin-1-yl]methanone chemical structure, C21H26N2O, CAS 510719-05-8

Biphenyl-4-yl[4-(butan-2-yl)piperazin-1-yl]methanone

CAS 510719-05-8C₂₁H₂₆N₂O

Biphenyl-4-yl(piperazin-1-yl)methanone chemical structure, C17H18N2O, CAS 5968-73-0

Biphenyl-4-yl(piperazin-1-yl)methanone

CAS 5968-73-0C₁₇H₁₈N₂O

1-(4-Phenylbenzoyl)piperazine-2,3-dicarboxylic acid chemical structure, C19H18N2O5

1-(4-Phenylbenzoyl)piperazine-2,3-dicarboxylic acid

C₁₉H₁₈N₂O₅

(3'-Fluoro-[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone chemical structure, C17H17FN2O, CAS 1181674-55-4

(3'-Fluoro-[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone

CAS 1181674-55-4C₁₇H₁₇FN₂O

(2'-Methoxy[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone chemical structure, C18H20N2O2, CAS 1182052-65-8

(2'-Methoxy[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone

CAS 1182052-65-8C₁₈H₂₀N₂O₂

(2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dicarboxylic acid chemical structure, C19H18N2O5, CAS 263845-86-9

(2R,3S)-1-(Biphenyl-4-carbonyl)-piperazine-2,3-dicarboxylic acid

CAS 263845-86-9C₁₉H₁₈N₂O₅

2-Methyl-1-(4-phenylbenzoyl)piperazine chemical structure, C18H20N2O, CAS 1240566-36-2

2-Methyl-1-(4-phenylbenzoyl)piperazine

CAS 1240566-36-2C₁₈H₂₀N₂O

3-Methyl-1-(4-phenylbenzoyl)piperazine chemical structure, C18H20N2O, CAS 1240581-42-3

3-Methyl-1-(4-phenylbenzoyl)piperazine

CAS 1240581-42-3C₁₈H₂₀N₂O

(4'-Amino[1,1'-biphenyl]-4-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C18H21N3O, CAS 1335042-64-2

(4'-Amino[1,1'-biphenyl]-4-yl)(4-methylpiperazin-1-yl)methanone

CAS 1335042-64-2C₁₈H₂₁N₃O

(4'-Chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone chemical structure, C17H16ClFN2O, CAS 1630806-39-1

(4'-Chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)(piperazin-1-yl)methanone

CAS 1630806-39-1C₁₇H₁₆ClFN₂O

tert-Butyl 4-(3'-methoxy[1,1'-biphenyl]-4-carbonyl)piperazine-1-carboxylate chemical structure, C23H28N2O4, CAS 1221403-89-9

tert-Butyl 4-(3'-methoxy[1,1'-biphenyl]-4-carbonyl)piperazine-1-carboxylate

CAS 1221403-89-9C₂₃H₂₈N₂O₄