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Murcko scaffold

Ring system with 3 rings and 21 atoms

37 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 37
With full pages: 9

Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCC(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=S(=O)(c1ccccc1)N1CCC(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

4-Phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile chemical structure, C19H20N2O2S, CAS 24476-55-9

4-Phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile

CAS 24476-55-9C₁₉H₂₀N₂O₂S

4-Phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid chemical structure, C19H21NO4S, CAS 84255-02-7

4-Phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid

CAS 84255-02-7C₁₉H₂₁NO₄S

4-Phenyl-1-(p-tolylsulphonyl)piperidin-4-ol chemical structure, C18H21NO3S, CAS 83863-40-5

4-Phenyl-1-(p-tolylsulphonyl)piperidin-4-ol

CAS 83863-40-5C₁₈H₂₁NO₃S

(±)-trans-3-Methyl-1-((4-methylphenyl)sulfonyl)-4-phenylpiperidine-4-carbonitrile chemical structure, C20H22N2O2S, CAS 25858-24-6

(±)-trans-3-Methyl-1-((4-methylphenyl)sulfonyl)-4-phenylpiperidine-4-carbonitrile

CAS 25858-24-6C₂₀H₂₂N₂O₂S

1-(4-Methylphenyl)sulfonyl-4-phenylpiperidine-4-carboxamide chemical structure, C19H22N2O3S, CAS 7146-69-2

1-(4-Methylphenyl)sulfonyl-4-phenylpiperidine-4-carboxamide

CAS 7146-69-2C₁₉H₂₂N₂O₃S

N-[2-[4-(4-Phenylpiperidin-1-yl)sulfonylphenyl]ethyl]acetamide chemical structure, C21H26N2O3S, CAS 384815-70-7

N-[2-[4-(4-Phenylpiperidin-1-yl)sulfonylphenyl]ethyl]acetamide

CAS 384815-70-7C₂₁H₂₆N₂O₃S

1-{[4-(Acetylamino)phenyl]sulfonyl}-4-phenyl-4-piperidinecarboxylic acid chemical structure, C20H22N2O5S, CAS 710990-72-0

1-{[4-(Acetylamino)phenyl]sulfonyl}-4-phenyl-4-piperidinecarboxylic acid

CAS 710990-72-0C₂₀H₂₂N₂O₅S

1-[(4-Fluorophenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid chemical structure, C18H18FNO4S, CAS 446029-84-1

1-[(4-Fluorophenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid

CAS 446029-84-1C₁₈H₁₈FNO₄S

1-[(4-Chlorophenyl)sulfonyl]-4-phenyl-4-piperidinecarboxylic acid chemical structure, C18H18ClNO4S, CAS 710990-75-3

1-[(4-Chlorophenyl)sulfonyl]-4-phenyl-4-piperidinecarboxylic acid

CAS 710990-75-3C₁₈H₁₈ClNO₄S

1-[(4-Bromophenyl)sulfonyl]-4-phenyl-4-piperidinecarboxylic acid chemical structure, C18H18BrNO4S, CAS 710990-81-1

1-[(4-Bromophenyl)sulfonyl]-4-phenyl-4-piperidinecarboxylic acid

CAS 710990-81-1C₁₈H₁₈BrNO₄S

1-(Benzenesulfonyl)-4-phenylpiperidine-4-carboxylic acid chemical structure, C18H19NO4S, CAS 101730-55-6

1-(Benzenesulfonyl)-4-phenylpiperidine-4-carboxylic acid

CAS 101730-55-6C₁₈H₁₉NO₄S

1-[(3,4-Difluorophenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid chemical structure, C18H17F2NO4S, CAS 793727-33-0

1-[(3,4-Difluorophenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid

CAS 793727-33-0C₁₈H₁₇F₂NO₄S

1-(2-Methoxybenzenesulfonyl)-4-phenylpiperidine-4-carboxylic acid chemical structure, C19H21NO5S, CAS 793727-34-1

1-(2-Methoxybenzenesulfonyl)-4-phenylpiperidine-4-carboxylic acid

CAS 793727-34-1C₁₉H₂₁NO₅S

1-[(3-Acetylphenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid chemical structure, C20H21NO5S, CAS 793727-35-2

1-[(3-Acetylphenyl)sulfonyl]-4-phenylpiperidine-4-carboxylic acid

CAS 793727-35-2C₂₀H₂₁NO₅S

4-(4-Chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile chemical structure, C19H19ClN2O2S, CAS 42138-31-8

4-(4-Chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile

CAS 42138-31-8C₁₉H₁₉ClN₂O₂S

3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile chemical structure, C20H22N2O2S, CAS 83863-65-4

3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile

CAS 83863-65-4C₂₀H₂₂N₂O₂S

4-(4-Chlorophenyl)-N,N-dimethyl-1-(p-tolylsulphonyl)piperidine-4-carboxamide chemical structure, C21H25ClN2O3S, CAS 84176-73-8

4-(4-Chlorophenyl)-N,N-dimethyl-1-(p-tolylsulphonyl)piperidine-4-carboxamide

CAS 84176-73-8C₂₁H₂₅ClN₂O₃S

4-(p-Chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid chemical structure, C19H20ClNO4S, CAS 84254-98-8

4-(p-Chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid

CAS 84254-98-8C₁₉H₂₀ClNO₄S

2-Ethoxy-5-[(4-phenylpiperidino)sulfonyl]benzenecarboxylic acid chemical structure, C20H23NO5S, CAS 866156-11-8

2-Ethoxy-5-[(4-phenylpiperidino)sulfonyl]benzenecarboxylic acid

CAS 866156-11-8C₂₀H₂₃NO₅S

1-[(4-Methylphenyl)sulfonyl]-4-phenylpiperidine chemical structure, C18H21NO2S, CAS 143632-57-9

1-[(4-Methylphenyl)sulfonyl]-4-phenylpiperidine

CAS 143632-57-9C₁₈H₂₁NO₂S

trans-(-)-3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid chemical structure, C20H23NO4S, CAS 83863-68-7

trans-(-)-3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carboxylic acid

CAS 83863-68-7C₂₀H₂₃NO₄S

trans-(1)-3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonyl chloride chemical structure, C20H22ClNO3S, CAS 97337-96-7

trans-(1)-3-Methyl-4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonyl chloride

CAS 97337-96-7C₂₀H₂₂ClNO₃S

{5-[4-(3,4-Dichlorophenyl)piperidine-1-sulfonyl]-2-methylphenyl}acetic acid chemical structure, C20H21Cl2NO4S, CAS 866785-69-5

{5-[4-(3,4-Dichlorophenyl)piperidine-1-sulfonyl]-2-methylphenyl}acetic acid

CAS 866785-69-5C₂₀H₂₁Cl₂NO₄S

4-(4-Methoxyphenyl)-1-(toluene-4-sulfonyl)piperidine chemical structure, C19H23NO3S, CAS 928256-40-0

4-(4-Methoxyphenyl)-1-(toluene-4-sulfonyl)piperidine

CAS 928256-40-0C₁₉H₂₃NO₃S