CompoundList
Sign in
Murcko scaffold

2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrazine scaffold

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
17
With full pages
3
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(c2cnccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrazine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(c2cnccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]pyrazine chemical structure, C15H18N4O3S, CAS 793691-00-6
2-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]pyrazine
CAS 793691-00-6C15H18N4O3S
2-(4-Tosylpiperazin-1-yl)pyrazine chemical structure, C15H18N4O2S, CAS 841223-22-1
2-(4-Tosylpiperazin-1-yl)pyrazine
CAS 841223-22-1C15H18N4O2S
2-[4-(4-Propylphenyl)sulfonylpiperazin-1-yl]pyrazine chemical structure, C17H22N4O2S, CAS 930859-22-6
2-[4-(4-Propylphenyl)sulfonylpiperazin-1-yl]pyrazine
CAS 930859-22-6C17H22N4O2S
2-[4-(2,5-Dimethoxyphenyl)sulfonylpiperazin-1-yl]pyrazine chemical structure, C16H20N4O4S, CAS 1021094-07-4
2-[4-(2,5-Dimethoxyphenyl)sulfonylpiperazin-1-yl]pyrazine
CAS 1021094-07-4C16H20N4O4S
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]pyrazine chemical structure, C14H15ClN4O2S, CAS 1021024-71-4
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]pyrazine
CAS 1021024-71-4C14H15ClN4O2S
2-[4-(3,4-Dimethoxyphenyl)sulfonylpiperazin-1-yl]pyrazine chemical structure, C16H20N4O4S, CAS 852678-11-6
2-[4-(3,4-Dimethoxyphenyl)sulfonylpiperazin-1-yl]pyrazine
CAS 852678-11-6C16H20N4O4S
2-[4-[3-(Trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]pyrazine chemical structure, C15H15F3N4O2S, CAS 851272-37-2
2-[4-[3-(Trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]pyrazine
CAS 851272-37-2C15H15F3N4O2S
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide chemical structure, C16H19N5O3S, CAS 927583-20-8
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide
CAS 927583-20-8C16H19N5O3S
2-(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)pyrazine chemical structure, C14H15FN4O2S, CAS 1021094-05-2
2-(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)pyrazine
CAS 1021094-05-2C14H15FN4O2S
2-[4-(4-tert-Butylbenzenesulfonyl)piperazin-1-yl]pyrazine chemical structure, C18H24N4O2S, CAS 1049549-65-6
2-[4-(4-tert-Butylbenzenesulfonyl)piperazin-1-yl]pyrazine
CAS 1049549-65-6C18H24N4O2S
2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrazine chemical structure, C14H16N4O2S, CAS 1021135-08-9
2-[4-(Benzenesulfonyl)piperazin-1-yl]pyrazine
CAS 1021135-08-9C14H16N4O2S
2-[4-(4-Bromobenzenesulfonyl)piperazin-1-yl]pyrazine chemical structure, C14H15BrN4O2S, CAS 1049493-43-7
2-[4-(4-Bromobenzenesulfonyl)piperazin-1-yl]pyrazine
CAS 1049493-43-7C14H15BrN4O2S
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)isobutyramide chemical structure, C18H23N5O3S, CAS 1049549-71-4
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)isobutyramide
CAS 1049549-71-4C18H23N5O3S
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)pivalamide chemical structure, C19H25N5O3S, CAS 1049493-59-5
N-(4-((4-(Pyrazin-2-yl)piperazin-1-yl)sulfonyl)phenyl)pivalamide
CAS 1049493-59-5C19H25N5O3S
3-Methyl-N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]sulfonyl}phenyl)butanamide chemical structure, C19H25N5O3S, CAS 1049549-77-0
3-Methyl-N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]sulfonyl}phenyl)butanamide
CAS 1049549-77-0C19H25N5O3S
3,3-Dimethyl-N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]sulfonyl}phenyl)butanamide chemical structure, C20H27N5O3S, CAS 1049529-03-4
3,3-Dimethyl-N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]sulfonyl}phenyl)butanamide
CAS 1049529-03-4C20H27N5O3S
{2-Methyl-5-[4-(pyrazin-2-yl)piperazine-1-sulfonyl]phenyl}acetic acid chemical structure, C17H20N4O4S, CAS 866785-72-0
{2-Methyl-5-[4-(pyrazin-2-yl)piperazine-1-sulfonyl]phenyl}acetic acid
CAS 866785-72-0C17H20N4O4S