CompoundList
Subcategory of Building blocks and research compounds

Chiral building blocks

Enantiomerically defined alcohols, amines, acids and auxiliaries used to build stereochemically pure molecules.
Chemicals
15,457
Suppliers
2,062
Racks of small vials in a compound library
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About chiral building blocks

Chiral building blocks are single enantiomer compounds used to build molecules with defined three-dimensional structure. The group covers chiral alcohols, amines, amino alcohols, epoxides such as glycidol derivatives, hydroxy acids such as lactic and malic acid esters, amino acid-derived compounds, chiral auxiliaries such as Evans oxazolidinones, resolving agents such as tartaric acid and mandelic acid derivatives, and the chiral pool from natural products such as terpenes and sugars.

Read more about chiral building blocks

Most new drugs are developed as single enantiomers, because the two mirror images can have different activity and safety. Chemists use chiral building blocks, asymmetric catalysis or resolution to reach the right stereoisomer, and buying a chiral intermediate can shorten a route considerably.

Ask for enantiomeric excess by chiral HPLC or GC, specific rotation, chemical purity, diastereomeric ratio for compounds with more than one stereocentre, and the absolute configuration with its basis. Racemisation can happen during storage or under basic or acidic conditions for some compounds, so check stability. For scale-up, ask whether the supplier uses resolution, biocatalysis or asymmetric synthesis, since this affects cost and impurity profile.

Top chiral building blocks

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Top suppliers of chiral building blocks

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Guides for buyers

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Frequently asked questions

Quick answers about buying chiral building blocks on CompoundList.

What are chiral building blocks?

Enantiomerically defined alcohols, amines, acids and auxiliaries used to build stereochemically pure molecules.

How many chiral building blocks are listed on CompoundList?

CompoundList lists 15,457 chemicals in chiral building blocks. 2,062 suppliers offer products in this category.

Which chiral building blocks are the most popular?

The most searched and traded chiral building blocks on CompoundList include Ethambutol hydrochloride, 5-Bromo-2'-deoxyuridine, Dexpropranolol hydrochloride, 2-Deoxyglucose and Sphingosine. They are part of the wider building blocks and research compounds family.

How do I buy chiral building blocks in bulk?

Open a chemical to compare its suppliers, or post one buy request with the product, grade, quantity and destination. Matching suppliers send you quotes, and your contact details stay private until you accept one.

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Cannot find the chiral building blocks you need?

Post one buy request with the grade, quantity and destination. Matching suppliers send you quotes, and your contact details stay private until you accept one.