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Murcko scaffold

Ring system with 3 rings and 21 atoms

257 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
257
With full pages
35
Scaffold SMILES

O=C(Nc1ccc(N2CCNCC2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(N2CCNCC2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 257 chemicals

N-[3-Chloro-4-(4-ethylpiperazin-1-yl)phenyl]-3-methyl-4-nitrobenzamide chemical structure, C20H23ClN4O3, CAS 673492-89-2
N-[3-Chloro-4-(4-ethylpiperazin-1-yl)phenyl]-3-methyl-4-nitrobenzamide
CAS 673492-89-2C20H23ClN4O3
N-[3-Chloro-4-(4-ethylpiperazin-1-yl)phenyl]-4-ethylbenzamide chemical structure, C21H26ClN3O, CAS 674359-58-1
N-[3-Chloro-4-(4-ethylpiperazin-1-yl)phenyl]-4-ethylbenzamide
CAS 674359-58-1C21H26ClN3O
5-Bromo-2-methoxy-3-methyl-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]benzamide chemical structure, C20H24BrN3O4S, CAS 708994-28-9
5-Bromo-2-methoxy-3-methyl-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]benzamide
CAS 708994-28-9C20H24BrN3O4S
N-[3-Bromo-4-(4-methylpiperazin-1-yl)phenyl]-3-(trifluoromethyl)benzamide chemical structure, C19H19BrF3N3O, CAS 477846-86-9
N-[3-Bromo-4-(4-methylpiperazin-1-yl)phenyl]-3-(trifluoromethyl)benzamide
CAS 477846-86-9C19H19BrF3N3O
N-[4-(4-Isopropylpiperazino)phenyl]-3-methylbenzenecarboxamide chemical structure, C21H27N3O, CAS 478065-80-4
N-[4-(4-Isopropylpiperazino)phenyl]-3-methylbenzenecarboxamide
CAS 478065-80-4C21H27N3O
N-[3-Fluoro-4-(4-methylpiperazino)phenyl]-3-methylbenzenecarboxamide chemical structure, C19H22FN3O, CAS 478079-60-6
N-[3-Fluoro-4-(4-methylpiperazino)phenyl]-3-methylbenzenecarboxamide
CAS 478079-60-6C19H22FN3O
4-Butoxy-N-[4-(4-methyl-1-piperazinyl)phenyl]benzamide chemical structure, C22H29N3O2, CAS 640241-64-1
4-Butoxy-N-[4-(4-methyl-1-piperazinyl)phenyl]benzamide
CAS 640241-64-1C22H29N3O2
5-Bromo-2-chloro-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide chemical structure, C20H21BrClN3O2, CAS 688331-42-2
5-Bromo-2-chloro-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide
CAS 688331-42-2C20H21BrClN3O2
2-Fluoro-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide chemical structure, C20H22FN3O2, CAS 688331-18-2
2-Fluoro-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide
CAS 688331-18-2C20H22FN3O2
N-[4-(4-Methylpiperazin-1-yl)phenyl]-3-propoxybenzamide chemical structure, C21H27N3O2, CAS 689746-73-4
N-[4-(4-Methylpiperazin-1-yl)phenyl]-3-propoxybenzamide
CAS 689746-73-4C21H27N3O2
4-Methyl-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide chemical structure, C21H25N3O2, CAS 688034-23-3
4-Methyl-N-[4-(4-propanoylpiperazin-1-yl)phenyl]benzamide
CAS 688034-23-3C21H25N3O2
3,5-Dichloro-4-methoxy-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide chemical structure, C19H21Cl2N3O2, CAS 689746-91-6
3,5-Dichloro-4-methoxy-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide
CAS 689746-91-6C19H21Cl2N3O2
2,5-Dichloro-N-[3-chloro-4-(4-propanoylpiperazin-1-yl)phenyl]benzamide chemical structure, C20H20Cl3N3O2, CAS 831251-03-7
2,5-Dichloro-N-[3-chloro-4-(4-propanoylpiperazin-1-yl)phenyl]benzamide
CAS 831251-03-7C20H20Cl3N3O2
N-[4-(4-Acetylpiperazin-1-yl)-3-chlorophenyl]-5-bromo-2-chlorobenzamide chemical structure, C19H18BrCl2N3O2, CAS 792946-78-2
N-[4-(4-Acetylpiperazin-1-yl)-3-chlorophenyl]-5-bromo-2-chlorobenzamide
CAS 792946-78-2C19H18BrCl2N3O2
2,3,5,6-Tetrafluoro-4-methoxy-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]benzamide chemical structure, C19H19F4N3O4S, CAS 766523-83-5
2,3,5,6-Tetrafluoro-4-methoxy-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]benzamide
CAS 766523-83-5C19H19F4N3O4S
N-[3-Chloro-4-(4-methylpiperazin-1-yl)phenyl]-3,4,5-triethoxybenzamide chemical structure, C24H32ClN3O4, CAS 766523-75-5
N-[3-Chloro-4-(4-methylpiperazin-1-yl)phenyl]-3,4,5-triethoxybenzamide
CAS 766523-75-5C24H32ClN3O4
N-[3-Chloro-4-(4-propanoylpiperazin-1-yl)phenyl]-4-cyano-2-fluorobenzamide chemical structure, C21H20ClFN4O2, CAS 838843-93-9
N-[3-Chloro-4-(4-propanoylpiperazin-1-yl)phenyl]-4-cyano-2-fluorobenzamide
CAS 838843-93-9C21H20ClFN4O2
5-Chloro-N-[4-(4-ethylpiperazin-1-yl)phenyl]-2-methoxybenzamide chemical structure, C20H24ClN3O2, CAS 792939-91-4
5-Chloro-N-[4-(4-ethylpiperazin-1-yl)phenyl]-2-methoxybenzamide
CAS 792939-91-4C20H24ClN3O2
2-Chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide chemical structure, C18H20ClN3O, CAS 689747-09-9
2-Chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide
CAS 689747-09-9C18H20ClN3O
N-[4-(4-Methylpiperazin-1-yl)phenyl]-3-(trifluoromethyl)benzamide chemical structure, C19H20F3N3O, CAS 303150-62-1
N-[4-(4-Methylpiperazin-1-yl)phenyl]-3-(trifluoromethyl)benzamide
CAS 303150-62-1C19H20F3N3O
2,6-Difluoro-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide chemical structure, C18H19F2N3O, CAS 303150-96-1
2,6-Difluoro-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide
CAS 303150-96-1C18H19F2N3O
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-chlorobenzamide chemical structure, C19H20ClN3O2, CAS 355412-36-1
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-chlorobenzamide
CAS 355412-36-1C19H20ClN3O2
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-4-chlorobenzamide chemical structure, C19H20ClN3O2, CAS 425608-37-3
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-4-chlorobenzamide
CAS 425608-37-3C19H20ClN3O2
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2,5-dichlorobenzamide chemical structure, C19H19Cl2N3O2, CAS 353760-74-4
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2,5-dichlorobenzamide
CAS 353760-74-4C19H19Cl2N3O2