Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 241 to 300 of 15,838 scaffolds
N-Phenylphthalimide102 chemicals, 3 rings![Scaffold c1ccc2c3c([nH]c2c1)CCCC3](/scaffold/XKLNOVWDVMWTOB-UHFFFAOYSA-N/structure.svg)
1,2,3,4-Tetrahydrocarbazole102 chemicals, 3 rings
Imidazo(1,5-a)pyridine101 chemicals, 2 rings
2,1,3-Benzoxadiazole100 chemicals, 2 rings
Thieno(2,3-d)pyrimidine100 chemicals, 2 rings
1-Benzylindole100 chemicals, 3 rings![Scaffold O=C(CSc1nnc(-c2ccco2)[nH]1)Nc1ccccc1](/scaffold/GAEXGVYSCYRWFO-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccco2)[nH]1)Nc1ccccc199 chemicals, 3 rings![Scaffold c1ccc(N=c2[nH]ccs2)cc1](/scaffold/OGVGQYZRJXSMGC-UHFFFAOYSA-N/structure.svg)
N-Phenyl-2-aminothiazole98 chemicals, 2 rings![Scaffold c1cnc2[nH]cnc2c1](/scaffold/GAMYYCRTACQSBR-UHFFFAOYSA-N/structure.svg)
Imidazo(4,5-b)pyridine97 chemicals, 2 rings
N'-Phenyl-N-benzoylthiourea96 chemicals, 2 rings
2-Azabicyclo(2.1.1)hexane95 chemicals, 3 rings
Fluoran93 chemicals, 5 rings![Scaffold O=c1[nH]cnc2sccc12](/scaffold/JEDVKUHCDPPWNR-UHFFFAOYSA-N/structure.svg)
Thieno(2,3-d)pyrimidin-4(3H)-one93 chemicals, 2 rings
Phthalide93 chemicals, 2 rings
Iminodibenyl93 chemicals, 3 rings
2-Phenyl-3(2H)-pyridazinone91 chemicals, 2 rings![Scaffold c1ccc(-c2cc3ccccc3[nH]2)cc1](/scaffold/KLLLJCACIRKBDT-UHFFFAOYSA-N/structure.svg)
2-Phenylindole91 chemicals, 3 rings
2-Piperidinopyridine90 chemicals, 2 rings
Imidazo(2,1-b)thiazole90 chemicals, 2 rings
8-Azabicyclo(3.2.1)octane89 chemicals, 2 rings
N-Phenylmaleimide89 chemicals, 2 rings![Scaffold c1ccc(-c2ncc[nH]2)cc1](/scaffold/ZCUJYXPAKHMBAZ-UHFFFAOYSA-N/structure.svg)
2-Phenylimidazole89 chemicals, 2 rings
Acetamide, N-phenyl-2-((1-phenyl-5-(4-pyridinyl)-1H-1,3,4-triazol-2-yl)thio)-88 chemicals, 4 rings![Scaffold O=c1[nH]c(-c2ccccc2)nc2ccccc12](/scaffold/VDULOAUXSMYUMG-UHFFFAOYSA-N/structure.svg)
2-Phenyl-4(3H)-quinazolinone88 chemicals, 3 rings
5,6,7,8-Tetrahydroquinoline88 chemicals, 2 rings
Spirohexane87 chemicals, 2 rings
Dihydrochalcone87 chemicals, 2 rings
O=C(CCc1ccc(-c2ccccc2)o1)Nc1ccccc187 chemicals, 3 rings![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
N-(1,3,4-Thiadiazol-2-yl)benzamide87 chemicals, 2 rings
2-Phenyl-benzofuran86 chemicals, 3 rings![Scaffold O=C(CSc1nnc(-c2cccs2)[nH]1)Nc1ccccc1](/scaffold/JSLNNBMNZZYKRR-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2cccs2)[nH]1)Nc1ccccc186 chemicals, 3 rings
Pyran, 4-phenyltetrahydro-86 chemicals, 2 rings
5-Benzylidene-2-thioxothiazolidin-4-one86 chemicals, 2 rings
5-Phenyl-1,2,4-oxadiazole86 chemicals, 2 rings
1-Benzoylpyrrolidine86 chemicals, 2 rings![Scaffold O=c1[nH]ncc2ccccc12](/scaffold/IJAPPYDYQCXOEF-UHFFFAOYSA-N/structure.svg)
1(2H)-Phthalazinone85 chemicals, 2 rings![Scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccccc1](/scaffold/QIXAJGKXBNMVDN-UHFFFAOYSA-N/structure.svg)
N-Phenyl-2-(5-phenyl-2H-(1,2,4)triazol-3-ylsulfanyl)-acetamide85 chemicals, 3 rings
N-(9-Fluorenylmethoxycarbonyl)pyrrolidine85 chemicals, 4 rings
N-Phenylcyclohexanecarboxamide84 chemicals, 2 rings
Thieno(2,3-b)pyridine84 chemicals, 2 rings
3,5-Diphenyl-4,5-dihydro-1H-pyrazole84 chemicals, 3 rings
1-(Phenylsulfonyl)-1H-imidazole84 chemicals, 2 rings
N-Phenethylbenzenesulfonamide83 chemicals, 2 rings
N-Phenyl-2-(phenylamino)acetamide83 chemicals, 2 rings
Bicyclo(2.2.1)heptan-2-one83 chemicals, 2 rings
1-Benzyl-1,2-dihydropyridin-2-one83 chemicals, 2 rings![Scaffold c1ccc2c(c1)[nH]c1cnccc12](/scaffold/AIFRHYZBTHREPW-UHFFFAOYSA-N/structure.svg)
beta-Carboline82 chemicals, 3 rings
3-Phenylcoumarin82 chemicals, 3 rings
C1CCC(OC2CCCOC2)OC182 chemicals, 2 rings
5H,6H,7H,8H-Imidazo[1,2-a]pyridine82 chemicals, 2 rings
2-Cyclopropylpyridine82 chemicals, 2 rings
2-Phenylmorpholine82 chemicals, 2 rings
4-Anilinoquinazoline81 chemicals, 3 rings
2,1,3-Benzothiadiazole81 chemicals, 2 rings![Scaffold c1ncc2cn[nH]c2n1](/scaffold/QUKPALAWEPMWOS-UHFFFAOYSA-N/structure.svg)
1H-Pyrazolo(3,4-d)pyrimidine81 chemicals, 2 rings
Isochromane80 chemicals, 2 rings
c1ccc2c(CC3CC4CCN3CC4)ccnc2c180 chemicals, 5 rings
N-Phenylpyrimidin-4-amine80 chemicals, 2 rings
O=C(CNC(=O)c1ccccc1)NN=Cc1ccc(OC(=O)c2ccccc2)cc180 chemicals, 3 rings
N-Phenyl-9-acridinamine80 chemicals, 4 rings