Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 181 to 240 of 15,838 scaffolds
![Scaffold c1[nH]nc2c1CCCC2](/scaffold/GDSQTWDUCDSZEY-UHFFFAOYSA-N/structure.svg)
4,5,6,7-Tetrahydro-1H-indazole126 chemicals, 2 rings
2-Phenylbenzothiazole126 chemicals, 3 rings![Scaffold O=c1cc[nH]n1-c1ccccc1](/scaffold/ILPGQKHPPSSCBS-UHFFFAOYSA-N/structure.svg)
1-Phenyl-1H-pyrazol-5-ol125 chemicals, 2 rings
1-Benzoylpiperazine125 chemicals, 2 rings
4-Phenylpyridine124 chemicals, 2 rings
C=C1CCCCC1=CC=C1CCCC2CCCC12123 chemicals, 3 rings
Dibenzofuran123 chemicals, 3 rings
C1=C2C3CCCCC3CCC2C2CCC3CCCCC3C2C1123 chemicals, 5 rings
N-Benzothiazol-2-yl-benzamide122 chemicals, 3 rings
1,2-Benzisoxazole122 chemicals, 2 rings
Hydrocarbostyril122 chemicals, 2 rings
3-Phenyl-3H-quinazolin-4-one122 chemicals, 3 rings
N-2-Thiazolylbenzamide121 chemicals, 2 rings![Scaffold O=c1[nH]cnc2nc[nH]c12](/scaffold/FDGQSTZJBFJUBT-UHFFFAOYSA-N/structure.svg)
Hypoxanthine120 chemicals, 2 rings
N-(Pyridin-2-yl)benzamide120 chemicals, 2 rings
1-Phenyl-3-(phenylamino)propan-1-one120 chemicals, 2 rings
1,2,4-Triazolo(1,5-a)pyrimidine119 chemicals, 2 rings
2,2'-Bipyridine118 chemicals, 2 rings
2-[(4-Oxo-3-phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]-N-phenylacetamide118 chemicals, 5 rings
O=C(CSc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1117 chemicals, 4 rings
5-Phenyl oxazole117 chemicals, 2 rings![Scaffold O=c1[nH]ccc2ccccc12](/scaffold/VDBNYAPERZTOOF-UHFFFAOYSA-N/structure.svg)
1(2H)-Isoquinolinone116 chemicals, 2 rings
3-Azabicyclo(3.1.0)hexane115 chemicals, 2 rings![Scaffold c1ccc(-c2cn[nH]c2)cc1](/scaffold/GPGKNEKFDGOXPO-UHFFFAOYSA-N/structure.svg)
4-Phenylpyrazole114 chemicals, 2 rings
RO-05-2921113 chemicals, 3 rings
(1,2,4)Triazolo(4,3-a)pyridine112 chemicals, 2 rings
(1,2,4)Triazolo(1,5-a)pyridine112 chemicals, 2 rings
1-(2-Pyridyl)piperazine112 chemicals, 2 rings
Pyrene111 chemicals, 4 rings
2,5-Diphenyl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine111 chemicals, 5 rings![Scaffold O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1](/scaffold/RPGQONZTKJZFKA-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1111 chemicals, 3 rings![Scaffold c1ccc(-c2cnc[nH]2)cc1](/scaffold/XHLKOHSAWQPOFO-UHFFFAOYSA-N/structure.svg)
4-Phenylimidazole111 chemicals, 2 rings![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)n[nH]1](/scaffold/HSDVCEWEQSYSJL-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)n[nH]1110 chemicals, 3 rings
O=C(NCCc1ccccc1)OCC1c2ccccc2-c2ccccc21110 chemicals, 4 rings
Diphenylthiourea109 chemicals, 2 rings
2-(Phenylmethyl)pyridine109 chemicals, 2 rings
O=C(NCc1ccccc1)OCC1c2ccccc2-c2ccccc21109 chemicals, 4 rings
Styrene oxide108 chemicals, 2 rings
Bicyclo(2.2.2)octane108 chemicals, 3 rings
N-2-Pyridylaniline108 chemicals, 2 rings![Scaffold S=c1[nH]nc(-c2ccccc2)[nH]1](/scaffold/JRLMMJNORORYPO-UHFFFAOYSA-N/structure.svg)
5-Phenyl-s-triazole-3-thiol108 chemicals, 2 rings
Phenylhydantoin108 chemicals, 2 rings![Scaffold c1ncc2cc[nH]c2n1](/scaffold/JJTNLWSCFYERCK-UHFFFAOYSA-N/structure.svg)
7H-Pyrrolo(2,3-d)pyrimidine107 chemicals, 2 rings
1-Benzylimidazole107 chemicals, 2 rings
2-Phenylpyrimidine107 chemicals, 2 rings![Scaffold c1cc(C2CC2)[nH]n1](/scaffold/TXWDVWSJMDFNQY-UHFFFAOYSA-N/structure.svg)
3-Cyclopropyl-1H-pyrazole107 chemicals, 2 rings
Bicyclo(3.1.0)hexane106 chemicals, 2 rings
4-Phenylpyrimidine106 chemicals, 2 rings
3-Phenylazetidine106 chemicals, 2 rings
Benzene, (cyclohexylmethyl)-105 chemicals, 2 rings
Benzaldehyde 4-phenylthiosemicarbazone105 chemicals, 2 rings
C1=CC2CCC1C2105 chemicals, 2 rings
Chromanone105 chemicals, 2 rings
O=c1c(Oc2ccccc2)coc2ccccc12105 chemicals, 3 rings
3-Phenylpyridine104 chemicals, 2 rings
Fluorenone104 chemicals, 3 rings
Phenanthrene104 chemicals, 3 rings
2-(1H-Pyrazol-1-yl)pyridine103 chemicals, 2 rings
4-Benzylpiperidine102 chemicals, 2 rings
2(1H)-Pyrimidinone, 3,4-dihydro-4-phenyl-102 chemicals, 2 rings