Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 301 to 360 of 15,838 scaffolds
2-Phenyl-1,3,4-thiadiazole80 chemicals, 2 rings
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals, 2 rings
N-Benzoylmorpholine79 chemicals, 2 rings![Scaffold O=C(CSc1nnc(-c2cccnc2)[nH]1)Nc1ccccc1](/scaffold/HPEIJTCNFVAYEW-UHFFFAOYSA-N/structure.svg)
N-Phenyl-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide79 chemicals, 3 rings
c1ccc2c(c1)CC1NCCc3cccc-2c3179 chemicals, 4 rings
Benzenesulfonamide, n-2-pyridinyl-79 chemicals, 2 rings
2-Azaspiro(3.3)heptane79 chemicals, 2 rings![Scaffold N=c1ccc2c(=O)n3ccccc3nc2[nH]1](/scaffold/VYCVENITSCHWDL-UHFFFAOYSA-N/structure.svg)
N=c1ccc2c(=O)n3ccccc3nc2[nH]179 chemicals, 3 rings![Scaffold c1cc2cc[nH]c2cn1](/scaffold/XLKDJOPOOHHZAN-UHFFFAOYSA-N/structure.svg)
6-Azaindole79 chemicals, 2 rings
2-Azabicyclo(2.2.1)heptane78 chemicals, 2 rings
Caprolactam78 chemicals, 1 ring![Scaffold O=C(CSc1nnc(-c2ccncc2)[nH]1)Nc1ccccc1](/scaffold/PBHQJIGZLPAKKZ-UHFFFAOYSA-N/structure.svg)
N-Phenyl-2-[(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide78 chemicals, 3 rings
4-Phenylcoumarin78 chemicals, 3 rings![Scaffold c1cnc2cc[nH]c2c1](/scaffold/XWIYUCRMWCHYJR-UHFFFAOYSA-N/structure.svg)
4-Azaindole78 chemicals, 2 rings![Scaffold O=C(c1ccccc1)c1cc[nH]c1](/scaffold/DSNSKSWTLGZGAN-UHFFFAOYSA-N/structure.svg)
3-Benzoylpyrrole77 chemicals, 2 rings
O=C(CSc1ccccc1)Nc1ccccc177 chemicals, 2 rings
2(1H)-Quinoxalinone, 3,4-dihydro-77 chemicals, 2 rings
Benzopyran77 chemicals, 2 rings
1-Benzyl-1,2,3-triazole77 chemicals, 2 rings
O=C(CN1CCN(c2ccccc2)CC1)Nc1ccccc175 chemicals, 3 rings
c1ccc(Cc2cncs2)cc175 chemicals, 2 rings
Flavan75 chemicals, 3 rings
2-(Phenoxymethyl)furan75 chemicals, 2 rings![Scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=Cc1ccccc1](/scaffold/XROOCFBOPUYMOC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=Cc1ccccc175 chemicals, 3 rings
Psoralen75 chemicals, 3 rings
Succinanil75 chemicals, 2 rings![Scaffold O=c1cnc2ccccc2[nH]1](/scaffold/FFRYUAVNPBUEIC-UHFFFAOYSA-N/structure.svg)
2(1H)-Quinoxalinone74 chemicals, 2 rings
N-Phenylcyclopropanecarboxamide74 chemicals, 2 rings
1-Phenyl-1H-pyrazol-5(4H)-one73 chemicals, 2 rings
C(=NNc1ccccc1)c1ccccc173 chemicals, 2 rings
4,5,6,7-Tetrahydro-1,3-benzothiazole73 chemicals, 2 rings
N-Benzylphenethylamine73 chemicals, 2 rings
O=C(NN=Cc1ccccc1OC(=O)c1ccccc1)c1ccccc173 chemicals, 3 rings
Phenyl N-phenylcarbamate73 chemicals, 2 rings
O=C(NN=Cc1ccccc1OC(=O)c1ccccc1)C(=O)Nc1ccccc172 chemicals, 3 rings
O=C1CCCC2=C1C(c1ccccc1)C=CO272 chemicals, 3 rings
2-Benzenesulfonamidopyrimidine72 chemicals, 2 rings
Benzhydrylpiperazine72 chemicals, 3 rings
(9H-Fluoren-9-yl)methyl piperidine-1-carboxylate72 chemicals, 4 rings
Thalidomide72 chemicals, 3 rings
Phenyl(4-(phenylmethyl)-1-piperazinyl)methanone72 chemicals, 3 rings
2-(Benzylamino)pyridine72 chemicals, 2 rings![Scaffold O=c1[nH]nc(-c2ccccc2)c2ccccc12](/scaffold/XCJLBNVENUPHEA-UHFFFAOYSA-N/structure.svg)
4-Phenyl-1-(2H)-phthalazinone72 chemicals, 3 rings
1-Phenyl-1H-benzoimidazole72 chemicals, 3 rings
2H-Thiopyran, tetrahydro-, 1,1-dioxide71 chemicals, 1 ring
O=C1CCCC2=C1C(c1ccsc1)C=CN2c1ccccc171 chemicals, 4 rings
Triphenylethylene71 chemicals, 3 rings
O=C1NC(=S)SC1=C1C(=O)Nc2ccccc2171 chemicals, 3 rings
1-Benzyl-3-phenylurea71 chemicals, 2 rings
1,8-Naphthyridine70 chemicals, 2 rings
5-Phenylpyrimidine70 chemicals, 2 rings![Scaffold c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc1](/scaffold/CBPCFMMAXNCEHC-UHFFFAOYSA-N/structure.svg)
3-(Benzylsulfanyl)-5-phenyl-4H-1,2,4-triazole69 chemicals, 3 rings![Scaffold C1=CC(c2ccccc2)c2c[nH]nc2O1](/scaffold/NPBSZCYFCQBNLH-UHFFFAOYSA-N/structure.svg)
C1=CC(c2ccccc2)c2c[nH]nc2O169 chemicals, 3 rings
3,4-Dihydroisoquinolin-1(2H)-one69 chemicals, 2 rings
1-(Benzenesulfonyl)benzimidazole68 chemicals, 3 rings
c1cc(B2OCCO2)ccn167 chemicals, 2 rings
2-Oxabicyclo[2.2.2]octane67 chemicals, 3 rings
Saccharin67 chemicals, 2 rings
Barbituric acid67 chemicals, 1 ring
Diazene, 2-naphthalenylphenyl-67 chemicals, 3 rings